Results 1 to 10 of about 2,073 (123)
Journal of Diabetes, 2023 Diabetic retinopathy (DR) is one of the most prevalent retinal disorders worldwide, and it is a major cause of vision impairment in individuals of productive age.
Xiongyi Yang +6 more
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抑制微RNA-30d-5p促进线粒体自噬缓解高糖作用下的足细胞损伤 [PDF]
浙江大学学报. 医学版目的探讨微RNA（miR）-30d-5p在高糖诱导下足细胞损伤中的作用。方法采用30 mmol/L葡萄糖诱导足细胞高糖化，使用miR-30d-5p抑制剂和模拟物转染，再经1 mg/mL 3-甲基腺嘌呤（3-MA）处理。定量逆转录聚合酶链反应检测miR-30d-5p的转染效率；流式细胞术检测细胞凋亡；蛋白质印迹法检测肾病蛋白、微管相关蛋白轻链（LC）3Ⅱ/LC3Ⅰ、P62、自噬相关基因（ATG）5蛋白、PTEN诱导假定激酶（PINK）1和Parkin基因（PARK2）蛋白表达。JC ...
蔡 莹 +5 more
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The Anatomical Record, Volume 306, Issue 12, Page 3214-3228, December 2023., 2023 Abstract The effectiveness and safety of electroacupuncture (EA) for constipation have been confirmed by numerous clinical studies and experiments, and there are also studies on the efficacy of EA for Parkinson's disease (PD) motor symptoms. However, there are few researches on EA for PD constipation.
Li‐Zhe‐Xiong Song +8 more
wiley +1 more source
Research progress in the relationship between mitochondrial dysfunction and osteoporosis [PDF]
, 2023 Osteoporosis (OP) is a chronic senile bone disease characterized by decreased bone mass and increased bone fragility. There are many inducing factors and the pathogenesis is complex. To explore the mechanism of OP and improve clinical efficacy has always
CHEN Yantong +4 more
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Anti-Proliferative Effect of 5-Heptadecylresorcinol on MDA-MB-231 Triple-Negative Breast Cancer Cells(5十七烷基间苯二酚对三阴性乳腺癌MDA-MB-231细胞增殖的抑制作用) [PDF]
Shipin kexue jishu xuebao, 2019 The effect of 5-heptadecylresorcinol (AR-C17) on human breast cancer MDA-MB-231 cells and its underlying mechanisms were investigated. CCK-8 assay was used to detect the change of cell viability under different treatments. DCF-DA fluorescence probe assay
XIE Mingsi(解明思) +4 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2023 线粒体电压依赖性阴离子通道1（VDAC1）是线粒体外膜上重要的通道蛋白，调控线粒体自噬，参与炎症因子的调节及炎症小体的激活，从而对炎症反应起着重要的作用。睡眠呼吸暂停综合征（OSAS）患者由于间歇性缺氧，氧化应激增加引起神经炎症，导致慢性损伤和神经元细胞凋亡，最终形成认知功能障碍。由于炎症在OSAS患者认知障碍的形成过程中起着重要的作用，而VDAC1调控着炎症小体的激活，因此本文综述了OSAS与炎症、OSAS与自噬之间的关系，并分析了VDAC1介导的炎症与线粒体自噬之间的相互作用 ...
刘纯飞, 徐平
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Recent advance in autophagy-related pathways and key biomarkers in major depressive disorder [PDF]
, 2023 Major depressive disorder (MDD) is a very common and severe mental disorder. Persistent emotional distress is one of its main clinical symptoms. The etiology of MDD is complex and highly heterogeneous, and has not yet been clarified.
HE Shen, LI Huafang, LI Siyuan
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自噬是一种高度保守的细胞自我调节机制，主要发生在哺乳动物和酵母细胞的溶酶体或液泡中，对维持生命活动及物质代谢的平衡至关重要。当细胞处于应激状态（如营养缺乏、物理化学刺激、感染、氧化应激等），或细胞质中积累了老化或受损的细胞器，自噬过程就会被激活，通过降解并循环利用受损的蛋白质和细胞器，清除潜在的有害物质，将降解产物用于能量供应和大分子的再合成，从而帮助细胞维持稳态。自噬激活剂是指能够促进细胞自清除过程的化合物或药物（如mTOR抑制剂、AMPK激动剂、SIRT1激活剂、溶酶体增强剂等 ...
侯宇, 赵英鹏
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Mitochondrial Damage due to Hypoxia and Its Forensic Significance [PDF]
, 2020 Mitochondria are the special organelle in eukaryotic cells. Their main functions are to synthesize energy required for cell activity by oxidative phosphorylation. Most of the oxygen absorbed by the body is consumed in the mitochondria.
HU Yi-kai, ZHANG Heng, XIAO Bi, et al
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E3泛素-蛋白连接酶Parkin介导线粒体自噬参与荷瘤小鼠心肌损伤
Zhongshan Daxue xuebao. Yixue kexue ban, 2022 目的观察荷瘤状态下小鼠心肌损伤情况，探讨park2基因编码的E3泛素-蛋白连接酶Parkin介导线粒体自噬在荷瘤小鼠心肌损伤中的作用及机制。方法通过PCR和蛋白质免疫印迹筛选和鉴定park2-/-小鼠；通过皮下移植瘤技术构建荷瘤动物模型，采用小动物心脏超声分析小鼠心脏结构与功能，观察心室内径、心室容积、射血分数、缩短分数以及心室壁厚度的变化；采用病理学方法分析小鼠心脏的形态学特征；使用Fluo-3、Rhod-2、DHE-ROS及JC-1探针进行线粒体损伤指标检测 ...
邓世杰, 李兴会, 蔡卫斌
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