Results 11 to 20 of about 2,073 (123)
Zhongshan Daxue xuebao. Yixue kexue ban, 2022 肌萎缩侧索硬化症（ALS）是一种典型的神经退行性疾病，其特征是大脑和脊髓中的运动神经元进行性病变。虽然DNA测序技术筛查出众多的ALS致病基因，拓宽了人们对ALS疾病发生的认识，但是这些功能各异的基因导致ALS疾病进程的分子机制仍是有待阐明的。随着基础研究的不断进展，人们发现线粒体的损伤，线粒体的动力学异常以及线粒体自噬等与神经退行性疾病如ALS的发病具有重要联系。在本篇综述中，我们主要讨论了ALS致病基因导致线粒体功能障碍的可能机制，旨在强调线粒体功能障碍在ALS疾病发展中的重要作用。
郑志隆, 郭兴
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Advances in mitochondrial autophagy regulation of bone remodeling and the role of drug intervention [PDF]
Bone remodeling is a complex process that includes two mutually coordinated phases of bone resorption and bone formation, which plays an important role in preventing bone aging and increasing bone density.
JIANG Honghui +5 more
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, 2019 肝脏作为体内代谢外源因素暴露最重要的器官之一,具有独特的血窦结构和丰富的免疫细胞亚群,构成了肝脏局部免疫微环境。其中,肝脏的先天免疫细胞既可通过清除病原体、抗原提呈作用参与宿主防御,还通过与肝实质细胞的相互作用参与外源因素介导的急性免疫反应、肝细胞毒性转归、慢性肝损伤以及肝致癌作用。线粒体作为细胞应激的关键靶细胞器,是整合肝脏局部免疫信号的分子互作平台,既通过线粒体质量控制精细调控细胞内的分子事件,也通过线粒体损伤相关分子模式介导不同细胞间通讯和交互作用调控免疫微环境的稳态 ...
张力引, 林忠宁, 林育纯
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Advances in Chinese medicine-mediated AMPK/mTOR signaling pathway for the treatment of osteoporosis [PDF]
, 2023 Osteoporosis （OP） is a systemic bone disease and a common orthopedic disorder in elderly patients. High morbidity， disability and mortality rates and medical cost of OP bring huge burden to the patients and their family.
Zhang Wenhao, Yi Lin, Xiang Wenyuan, Remira·Aimaiti, Deng Yingjie, Liao Jun, Liang Zhiquan, Li Leijiang, Fang Rui
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Zhongguo shiyan zhenduanxue, 2021 目的探讨热休克蛋白90(HSP90)在结肠癌介导肝脏损伤中的作用,为HSP90抑制剂的临床应用提供一定的数据支持。方法健康的SPF级BALB/C雄性6-8周龄小鼠20只,将5×106结肠癌CT-26细胞接种至小鼠右后腿外侧,实验采用随机分组,分为对照组和PU-H71组,每组各10只,PU-H71组经尾静脉给药(2mg/kg),每周2次,持续给药2周,对照组给予等量生理盐水。通过HE染色从病理学角度确定肝损伤程度;采用试剂盒检测小鼠血清中谷草转氨酶(AST)、谷丙转氨酶(ALT)、丙二醛(MDA ...
于爽 +5 more
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Food-Derived Natural Products Prevent Neurodegenerative Diseases by Regulating Mitophagy: A Review of Research Progress [PDF]
Neurodegenerative diseases are often characterized by progressive dysfunction and loss of neuronal structure and function, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease. Mitochondria, the center of energy metabolism in the body,
CAO Yuxin, ZHANG Yanqing, QI Wuqin, XIE Junbo
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Function of Apoptosis and Autophagy in Cardiovascular Diseases [PDF]
, 2017 细胞凋亡与自噬是普遍存在于各种细胞内的生命现象,广泛参与了机体的生理、病理过程,且二者有着多因子、多通路的相互影响,这种错综复杂的关系贯穿于各种心血管疾病的始终,对多种心血管疾病的发生发展转归起重要作用。现对细胞凋亡与自噬及其相互关系进行梳理,并综述其在心血管疾病中的作用。Apoptosis and autophagy are common life phenomenon in various cells, which widely involve in physiological and ...
杨雅瑾, 林小凤, 费燕, 陈尚瑜
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Inflammatory activation of BV2 cells induced by manganese involving with mitophagy [PDF]
Objective To investigate whether manganese-induced inflammatory activation in BV2 cells is associated with mitophagy. Methods Mouse microglia cells BV2 were exposed to different concentrations of manganese (0 μmol/L, 50 μmol/L and 100 μmol/L) for 12 h ...
DONG Zhenshan +11 more
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p32 regulates ULK1 stability and autophagy [PDF]
, 2015 细胞自噬是细胞在营养匮乏条件下，降解细胞内成分以维持细胞必要活动与生命的一种细胞进程。线粒体自噬是一种选择性的细胞自噬，功能紊乱的线粒体可以通过这种方式被自噬体降解。并且线粒体自噬代表了线粒体质量控制的一种方式，而这种方式对维持最佳的线粒体生物能学水平很重要。大量的研究都表明了，ULK1在诱导细胞自噬与线粒体自噬中的关键作用，但是关于ULK1自身调节的报道却很少。p32是一个具有分子伴侣功能的蛋白，在维持线粒体膜电位差以及氧化磷酸化中起到非常重要的作用。但是p32与线粒体稳态控制的关系却没有被研究清楚 ...
焦海峰
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Influence of transient receptor potential cation channel 6 on renal tubulointerstitial inflammation in mice with diabetic kidney disease and its mechanism [PDF]
Objective To investigate the influence of transient receptor potential cation channel 6 (TRPC6) on renal tubulointerstitial inflammation in mice with diabetic kidney disease (DKD) and its mechanism. Methods A total of 36 male C57/BL6J mice, aged 6 weeks,
LIU Congcong, ZHANG Xingjian, DING Lin, ZHANG Yao, ZHANG Dongjie, MA Ruixia
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