Results 61 to 70 of about 15,066 (234)
Zhongguo cuzhong zazhi, 2019 脑小血管病（cerebral small vessel disease，CSVD）是临床上常见的一类与年龄相关的脑血管 疾病。脑白质高信号（white matter hypertensities，WMH）是CSVD的影像标志物之一。WMH患病率极高， 与认知障碍的发生发展密切相关，但其影像表现及临床症状的异质性为早期发现、早期诊断带来了 困难。本文从病理学、影像学及生物学3方面对WMH发生发展及其导致认知障碍的机制研究现况进 行综述，同时总结目前的治疗策略，提出了接下来的研究目标及方向 ...
王兴，施余露，陈奕奕，王伊龙
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Metabolomic Study on the Advanced Pancreatic Cancer Model in Nude Mouse [PDF]
, 2016 胰腺癌是一种恶性程度极高的消化道类恶性肿瘤，早期无显著病征，病人在确诊时病情基本已处于中晚期，而研究显示，直径小于2cm和1cm的胰腺癌术后5年生存率分别可达30%-60%和超过75%，远高于中晚期术后5年生存率。 本文为课题“基于核磁共振的代谢组学技术发现胰腺癌的生物标志物及早期诊断应用”的一部分。整个课题目的在于通过系统分析动物和人类胰腺癌中晚期模型代谢通道的异同点，然后通过构建动物早期胰腺癌模型，并结合中晚期动物与人类胰腺癌代谢通路的共同点 ...
李志水
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The homogenization of China's city flowers and city trees
People and Nature, Volume 7, Issue 2, Page 530-540, February 2025.Abstract Cultural homogeneity, similar to the loss biodiversity, is a significant global issue that is increasingly gaining attention. City flowers and city trees (CFTs) serve as emblematic cultural symbols of modern cities, often referred to as the ‘green business card’. While many cities have established CFTs in recent decades, there are instances of
Zhuo Cheng +6 more
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Ultrasound in Obstetrics &Gynecology, Volume 64, Issue 4, Page 470-479, October 2024.ABSTRACT Objectives Our aim was to examine the prenatal profiles of pregnancies affected by an atypical chromosomal aberration, focusing on pathogenic copy‐number variants (pCNVs). We also wanted to quantify the performance of combined first‐trimester screening (cFTS) and a second‐trimester anomaly scan in detecting these aberrations. Finally, we aimed
K. Gadsbøll +6 more
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The development for emerging biomarkers of lymphangioleiomyomatosis
Orphanet Journal of Rare Diseases抽象 Lymphangioleiomyomatosis (LAM) is a rare, slowly progressing, low-grade metastatic tumor primarily affecting women. Currently, vascular endothelial growth factor–D (VEGF-D) is the only validated diagnostic biomarker, enabling diagnosis of LAM without ...
Liting Huang +3 more
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Source apportionment of source-specific biomarkers from sedimentary organic matters and coastal organic aerosols in Taiwan Stra [PDF]
, 2017 在海-陆相互作用（如河流输入和大气沉降等）和人类活动（如化石燃料燃烧等）的影响下，大量的陆源有机质由河流和风尘携带下被输送到边缘海，导致边缘海沉积碳汇同时也是一个重要的陆源有机碳汇。由于不同的来源的有机碳汇在不同时间尺度上影响着大气CO2的浓度，正确认识海洋的沉积碳汇对于全面了解全球碳循环具有重要意义。河流和大气的颗粒物输送是海洋沉积陆源物质的两个重要来源，由于传输途径的差异导致了河流和大气输送的有机质在物理生物化学性质和在传输埋藏的行为上有很大的差别。从海-气相互作用的角度来看 ...
陶舒琴
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Conservation Biology, Volume 38, Issue 3, June 2024.Abstract Reintroduced populations are typically considered to progress through establishment, growth, and regulatory phases. However, most reintroduction programs do not monitor intensively enough to test this conceptual model. We studied population indices derived from track activity of 4 threatened species (greater bilby [Macrotis lagotis], burrowing
Katherine E. Moseby +3 more
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Update on the role of cytokines and chemokines in canine atopic dermatitis
Veterinary Dermatology, Volume 35, Issue 1, Page 25-39, February 2024.Background – Cytokines and chemokines play central roles in the pathogenesis of canine atopic dermatitis (cAD). Numerous studies have been published and provide new insights into their roles in cAD. Objectives – To summarise the research updates on the role of cytokines and chemokines in the pathogenesis of cAD since the last review by the ...
Chie Tamamoto‐Mochizuki +6 more
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The discovery of new biomarkers of hepatocellular carcinoma [PDF]
, 2017 肝癌，尤其是肝细胞型肝癌是一种常见的恶性肿瘤，发现晚且死亡率高，因此及时发现、尽早治疗具有重要的临床意义。而生物标志物可作为早期临床诊断的工具，可显著提高患者的生存率。当前临床常用的肝细胞型肝癌的血清早期诊断标志物主要有甲胎蛋白（AFP）和甲胎蛋白异质体（AFP-L3）等，但这些检测指标的灵敏度和特异性均有待提高。而外泌体是一种与肿瘤的发生、发展密切相关的分泌型囊泡。已有报道显示，许多肿瘤中均可分泌包含特异的、可做潜在生物标志物的外泌体，因此，利用外泌体寻找生物标志物是目前研究的热点 ...
王琳钧
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Zhongguo cuzhong zazhi, 2023 目的 探讨缺血性卒中领域孟德尔随机化研究的现状及热点，为该领域未来研究方向、药物靶点挖掘方向和探索机制提供参考。 方法 在Web of Science核心合集中检索截至2022年9月应用孟德尔随机化研究缺血性卒中的相关英文文献，用CiteSpace进行发表文献的合作网络分析（国家、机构、学者）、文献共被引情况分析、关键词共现和聚类分析。利用PharmSnap全球新药数据库查询经孟德尔随机化确定与缺血性卒中具有因果关系的生物标志物的药物研发情况。 结果 检索到文献200篇 ...
李兰欣, 许喆, 勾岚, 石延枫, 刘阳, 赵曼曼, 李昊, 程丝
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