Results 41 to 50 of about 25,036 (174)
ABCA12 Frameshift Deletion in Domestic Cats With Ichthyosis Fetalis
Veterinary Dermatology, EarlyView.ABSTRACT Background Ichthyosis fetalis (IF), also known as harlequin ichthyosis, is a rare and often fatal autosomal recessive congenital skin disorder. It is characterized by thickened, hard skin plaques and deep skin fissures that limit mobility and cause malformations of the eyes, lips and ears.
Jeanna M. Blake +2 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2018 机体的免疫功能与恶性肿瘤的发生发展具有密切的关系,当机体免疫功能低下时,肿瘤的发生率明显升高,但肿瘤患者在患病期间同样可产生大量的免疫抑制因子对免疫功能造成抑制作用[1]。直肠癌患者本身的免疫功能较低,手术治疗时,侵入性操作、麻醉处理以及疼痛等因素可进一步对患者的免疫功能产生抑制,尤其是细胞免疫功能 ...
任德华, 陈涛, 赵光忠
doaj
Identifying a novel RARγ ligand and exploring its biological function [PDF]
, 2016 视黄酸受体γ(RetinoicAcidReceptorgamma，RARγ)，作为核受体超家族重 要成员之一，在生物体生长、发育、代谢、免疫、分化、增殖、炎症、凋亡等过 程中均发挥着重要作用。RARγ一般与核受体RXRα形成异源二聚体形式，在细 胞核发挥调控基因转录的活性。但是近年来的研究发现，RARγ以及其他一些核 受体会出核与胞质中的蛋白直接相互作用进而快速参与到胞外的信号调控，发挥 核受体的“非基因型作用”。因此，RARγ一直以来都是药物干预和治疗过程中 重要且极具吸引力的靶点 ...
凌小滨
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Veterinary Dermatology, Volume 37, Issue 2, Page 293-305, April 2026.Background: Canine atopic dermatitis (cAD) is a common, chronic skin condition characterised by epidermal barrier dysfunction, immune dysregulation and cutaneous dysbiosis. While “emollient plus” formulations are widely used in human atopic dermatitis, their role in cAD remains underexplored. Hypothesis/Objectives: To evaluate the clinical efficacy and
Beatriz Fernandes +8 more
wiley +1 more source
Huli yanjiu, 2008 摘要： （免费在线浏览）现代康复技术水平的发展,使疾病死亡率逐步下降,生存率不断提高,如何更有效地提高病人生命和生活质量,已成为康复护理学科的重要课题。骨科康复护理,是在对原发病治疗的基础上着重强调功能的康复护理,功能锻炼对于骨科病人手术及保守治疗后的康复起着非常重要的作用。骨科病人不再满足临床治愈,而是要求以良好的功能恢复为目标。目前临床上主要是在医护人员的指导下进行功能锻炼。护士对病人功能锻炼的认识，指导方法的技巧是提高病人功能锻炼依从性的重要保证 ...
曹芳, 吴淑媛
doaj
, 2010 果糖-1,6-二磷酸酶(EC 3.1.3.11)是糖异生中的关键限速酶之一,在糖代谢中起重要作用。哺乳动物存在肝脏型和肌肉型两种果糖-1,6-二磷酸酶同工酶,分别由Fbp1和Fbp2编码。银鲫作为我国重要的经济养殖鱼类,尚无果糖-1,6-二磷酸酶基因的有关资料,其组织分布特征和胚胎发育模式亦不清楚。本研究采用RACE方法从银鲫原肠胚SMART cDNA文库中扩增了果糖-1,6-二磷酸酶基因的全长cDNA,其长度为1170 bp,编码337个氨基酸残基,多重序列比对和系统发育分析表明该基因为肝脏型果糖 ...
桂建芳, 王锐, 肖青
core
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Cost‐effective and efficient non‐noble‐metal catalysts for selective lignin hydrogenolysis remain elusive, representing a significant challenge in biorefinery. Here, we prepared a nitrogen‐doped carbon supported CoNi bimetallic catalyst, which was successfully derived from zeolitic imidazolate framework (ZIF) via high‐temperature pyrolysis ...
Xingwei Luo +3 more
wiley +1 more source
The role of jumping translocation breakpoint gene promoting instability of genome and the biological function of its protein and potential clinical value [PDF]
, 2014 染色体不稳定性是大多数肿瘤细胞特别是实体瘤细胞和体外转化细胞的基本特征。其表现形式包括整条染色体的获得或缺失，杂合缺失，染色体易位重排，基因扩增等。目前认为染色体不稳定是肿瘤形成的始发因素，出现在肿瘤进展的早期阶段。体内外各种损伤刺激导致的基因组DNA链的断裂是染色体不稳定的根本原因。我们的研究发现，跳跃易位断裂点基因（JTB）在胃癌、肝癌中存在广泛的基因扩增和基因易位行为，而基因的扩增和易位是DNA双链断裂后异常修复的最终结果。JTB基因的断裂易位将导致其编码跨膜结构域的基因序列丢失 ...
刘贇鹏
core
Electrolyte With Functionalized Boron Nitride Nanosheets for Dendrite‐Free Lithium Metal Anodes
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Lithium metal batteries (LMBs) are regarded as promising candidates for the next‐generation high‐energy‐density storage systems due to their unparalleled theoretical energy density and low redox potential. However, the commercialization of LMBs is tremendously plagued by the barbaric growth of lithium dendrite and the intricate decomposition ...
Ji Zhou +5 more
wiley +1 more source
The synthesis of triazole derivatives on mushroom tyrosinase and their mechanisms [PDF]
, 2016 酪氨酸酶广泛的存在于各生物体内，其产物多巴醌能与氨基酸或者蛋白质聚合黑色素，该酶是合成黑色素的关键酶。然而黑色素的过量合成会引起雀斑、黄褐斑、老年斑等色素沉积性皮肤病，此外研究表明，酪氨酸酶还与帕金森综合症、昆虫蜕皮、果蔬褐变有密切关系。因此，控制酪氨酸酶活性的研究在农业、制药业及化妆品行业有重要开发价值。 4-氨基-3-肼基-5-巯基-1，2，4-三唑（AHMT）为五元氮杂环，是酰胺键的电子等排物，也具有潜在的配位键，而苯甲醛类衍生物为酪氨酸酶底物的类似物，可以竞争性抑制酶失活性 ...
喻枫
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