Results 31 to 40 of about 29,479 (145)

Polydopamine-Functionalized Graphene Oxide: A Versatile Nanocarrier for Chemotherapy and Photothermal Therapy [PDF]

open access: yes, 2015
光热治疗是一种新型的肿瘤治疗技术,与传统的治疗手段相比,其具有独特的优点,如侵入性低、恢复时间短及并发症发生率小,而将光热治疗与传统的化学药物治疗结合在一个体系里,使热和化疗药物同时作用于肿瘤部位,能够更有效的杀死癌细胞。 石墨烯作为一种二维碳纳米材料,具有超高的比面积和强的近红外光吸收能力,在药物输送与光热治疗方面有着潜在的应用价值。然而,目前的研究中,石墨烯主要是通过π-π堆叠和疏水性相互作用装载疏水性药物,无法实现对那些与之无相互作用的亲水性药物的装载 ...
张馨元
core  

Development of a Four‐Language Questionnaire to Investigate Environmental Risk Factors for the Development of Canine Atopic Dermatitis and to Monitor Disease Course and Progression

open access: yesVeterinary Dermatology, Volume 37, Issue 1, Page 34-44, February 2026.
Background: The chronic and multifactorial character of canine atopic dermatitis (cAD) often leads to poor disease control and treatment dissatisfaction. Environmental factors are likely to contribute to the disease development and may play a more important role than assumed previously.
Patricia Clara‐Maria Rhodius   +11 more
wiley   +1 more source

A Clinical Observation of Concomitant Therapy of Erlotinib and Whole Brain Radiotherapy in Patients of NSCLC Combined with Brain Metastases [PDF]

open access: yes, 2009
Background and objective Treatments to brain metastases in patients of NSCLC include operation, chemotherapy and radiotherapy, while the disease control rate of brain lesions is not so good, the media survival time is 4-6 months.
Jing ZHAO, Lihong ZHANG, Qiang FU
core  

Evaluation of Chlorhexidine‐Containing Shampoos: In Vitro Efficacy Against Staphylococcus pseudintermedius and Lathering Ability

open access: yesVeterinary Dermatology, Volume 37, Issue 1, Page 148-160, February 2026.
Background: The antibacterial efficacy of chlorhexidine shampoo is directly affected by formulation and bathing factors. Hypothesis/Objective: To evaluate the in vitro antibacterial efficacy of chlorhexidine‐containing shampoos at various dilutions and to compare their lathering ability.
Emily E. Binversie   +2 more
wiley   +1 more source

二苯环丙烯酮局部免疫治疗难治性斑秃的疗效分析

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2018
【目的】探讨难治性斑秃患者局部外用二苯环丙烯酮(DPCP)的疗效及其影响因素。【方法】回顾性分析127例难治性斑秃患者外用DPCP的有效率、不良反应、复发率和再次治疗的有效率,并分析临床资料、皮肤镜征象、检验指标对疗效的影响。【结果】本组难治性斑秃患者DPCP 治疗治愈率、有效率分别为37.1%、44.8%,复发率为36.5%,复发后再治疗有效率为63.2%。26.8%患者出现较明显副作用如严重接触性皮炎、泛发性接触性皮炎、白癜风等。发病年龄早、病程长、稳定期、脱发面积大、斑秃类型为全普秃和带状型 ...
詹济滂   +5 more
doaj  

Novel Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia [PDF]

open access: yes, 2016
缺血乏氧是肿瘤微环境的重要特征之一,肿瘤的缺血乏氧不仅促进了肿瘤细胞的侵袭转移,同时还增强肿瘤对化疗药物的耐药性。肿瘤相关巨噬细胞(Tumor-associatedmacrophages,TAMs)浸润在肿瘤微环境之中,通常在肿瘤缺血乏氧区域富集。肿瘤相关巨噬细胞作为肿瘤微环境的重要功能细胞,其在肿瘤细胞的增殖、侵袭、转移、化疗耐药等肿瘤进展的各个阶段均发挥着重要作用。鉴于此,我们提出一种新型的肿瘤治疗策略,以期改变肿瘤微环境的同时,增强实体瘤对化学治疗的疗效 ...
宋曼莉
core  

Single Cold Atmospheric Plasma Therapy May Improve the Treatment Outcome of Canine Otitis Externa With Secondary Infection

open access: yesVeterinary Dermatology, Volume 37, Issue 1, Page 103-110, February 2026.
Background: Otitis externa with secondary bacterial or yeast infection is a common problem in small animal practice. Cold physical plasma (CPP) has been reported to have antimicrobial activity in vitro. Results: Ears treated additionally with CPP showed lower otic scores after 21 days compared to nontreated ears, although this difference was not ...
Ralf S. Mueller, Cosima Bouassiba
wiley   +1 more source

复合声治疗对不同类型听阈正常耳鸣患者的疗效观察

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2018
: 【目的】探讨复合声对听阈正常耳鸣患者的疗效,为纯音听阈正常耳鸣患者治疗提供参考。【方法】 收集2014年9月1日-2015年12月30日间中山大学附属第一医院门诊就诊的纯音测听听阈正常的46例耳鸣患 者,耳鸣持续时间>3个月。详细收集患者病例资料如年龄、性别、耳鸣特点、伴随症状等,并行纯音测听、耳鸣测 听检查,以及耳鸣致残量表(THI)评分和视觉模拟评分(VAS)评分。给予复合声治疗,选取主频与耳鸣频率一致 的自然声,并挑选音乐主频覆盖耳鸣频率中心的音乐片段 ...
李昌武   +3 more
doaj  

Injectable Biomimetic Composite Hydrogel Scaffold With Tissue‐Engineered Cartilage Matrix for Articular Cartilage Regeneration

open access: yesRare Metals, Volume 45, Issue 1, January 2026.
ABSTRACT Articular cartilage regeneration remains a significant challenge because of its limited intrinsic healing capacity and the inadequacy of conventional treatments for restoring structural and functional integrity. In this study, a novel injectable composite hydrogel scaffold was designed to mimic the extracellular matrix (ECM) of native ...
Zhong‐Lian Wu   +13 more
wiley   +1 more source

齐拉西酮针剂治疗精神分裂症患者激越症状的Meta回归

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2020
【目的】基于已发表的齐拉西酮速效针剂对精神分裂症患者激越症状治疗的中英文文献,综合分析齐拉西酮针剂治疗激越症状的疗效及其相关影响因素。【方法】检索PubMed、EMBASE、Web of Knowledge、Cochrane Library、万方数据,中国期刊全文数据库,中国生物医学文献数据库(CBM disc)和维普网,应用随机临床试验报告的声明(CONSORT)为参照标准进行入组和评价文献,采用STATA软件进行Meta分析,以疗效的效应值为因变量,性别、年龄、治疗前PANSS量表总分 ...
苏亮   +4 more
doaj  

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