Results 21 to 30 of about 5,763,646 (167)
Veterinary Dermatology, Volume 32, Issue 5, Page 477-e131, October 2021., 2021 Background – Interleukin (IL)‐31 is an important mediator in canine atopic dermatitis (cAD) and also may be dysregulated in other allergic diseases. Hypothesis/Objectives – To demonstrate the efficacy and safety of lokivetmab (canine anti‐IL‐31 monoclonal antibody) for treatment of pruritus associated with allergic dermatitis in dogs.
Leen Van Brussel +4 more
wiley +1 more source
Treatment of equine sarcoids using recombinant poxviruses expressing feline interleukin‐2
Veterinary Dermatology, Volume 32, Issue 3, Page 283-e77, June 2021., 2021 Background – Interleukin (IL)‐2 stimulates antitumour immunity and is successfully used for the treatment of different neoplasias. Hypothesis/Objectives –Canarypox virus locally expressing feline IL‐2 is safe and can be used to treat equine sarcoids. Conclusions –Treatment of equine sarcoids with recombinant canarypox virus expressing feline IL‐2 seems
Johanna Loschelder‐Ostrowski +4 more
wiley +1 more source
Serum concentrations of IL‐31 in dogs with nonpruritic mast cell tumours or lymphoma
Veterinary Dermatology, Volume 31, Issue 6, Page 466-e124, December 2020., 2020 Background The aim of this study was to compare serum interleukin (IL)‐31 concentrations in dogs with lymphoma and mast cell tumours (MCT) without pruritus to those of healthy dogs. Hypothesis/Objectives To determine if IL‐31 plays a role in tumour pathogenesis and if IL‐31 could be a biological marker for disease progression.
Nataliia Ignatenko +8 more
wiley +1 more source
Veterinary Dermatology, Volume 31, Issue 2, Page 154-e30, April 2020., 2020 Background Thymic stromal lymphopoietin (TSLP) plays a key role in the development of allergic inflammation. Little is known about possible triggers of equine TSLP expression. Hypothesis To investigate TSLP expression in equine insect bite hypersensitivity (IBH) skin lesions.
Iva Cvitas +4 more
wiley +1 more source
Long‐term use of lokivetmab in dogs with atopic dermatitis
Veterinary Dermatology, Volume 35, Issue 6, Page 683-693, December 2024.Background – Lokivetmab, a caninised monoclonal antibody against interleukin (IL)‐31, is an effective treatment for the pruritus associated with canine atopic dermatitis (cAD). Objectives – To investigate the efficacy and safety of lokivetmab during long‐term treatment defined as at least three consecutive lokivetmab injections in atopic dogs under ...
Bettina Kasper +2 more
wiley +1 more source
Veterinary Dermatology, Volume 35, Issue 6, Page 595-604, December 2024.Background – Mycobacterium cell wall fraction (MCWF) is derived from nonpathogenic Mycobacterium phlei and is used as an immunomodulatory compound in clinical practice, yet its mode‐of‐action requires further research. Objective – To evaluate the host response to MCWF in canine peripheral blood mononuclear cells (PBMCs) by using enzyme‐linked ...
Robert Ward +9 more
wiley +1 more source
Update on the role of cytokines and chemokines in canine atopic dermatitis
Veterinary Dermatology, Volume 35, Issue 1, Page 25-39, February 2024.Background – Cytokines and chemokines play central roles in the pathogenesis of canine atopic dermatitis (cAD). Numerous studies have been published and provide new insights into their roles in cAD. Objectives – To summarise the research updates on the role of cytokines and chemokines in the pathogenesis of cAD since the last review by the ...
Chie Tamamoto‐Mochizuki +6 more
wiley +1 more source
Developmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019 目的 本国际临床指南由欧洲残疾儿童学会（the European Academy of Childhood Disability，EACD）牵头制定，旨在解决发育性协调障碍（developmental coordination disorder，DCD）的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题，通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础，以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类，最终转化为指南建议。并由国际 ...
Jing Hua +6 more
wiley +1 more source
The spectrum-effect relationship study on Tripterygium Wilfordii glycoside tablet based on therapeutic effect and toxicity [PDF]
, 2015 雷公藤多苷片是由雷公藤的干燥根提取、纯化制得的，具有良好的抗炎、免疫抑制的药理作用，临床上广泛用于治疗类风湿关节炎、肾病综合征等疾病，疗效确切。但临床不良反应高发，且临床应用表明不同厂家的雷公藤多苷片药效和毒副反应有较大差异。由于雷公藤化学成分复杂，多个成分既为有效成分又为毒性成分，而目前多仅对雷公藤甲素(雷公藤内酯醇)或雷公藤内酯甲进行含量控制，无法全面的对雷公藤多苷片的药效和毒性进行控制。明确药效成分和毒性成分，建立全面科学、符合中药制剂整体起效特点的质量控制方法，是当前研究的热点和难点 ...
池婕
core
Curcumin inhibit VEGF expression via IGF-1R pathway in hypoxic-induced HepG2 human hepatocellular carcinoma cells [PDF]
, 2016 肝细胞性肝癌（hepatocellularcarcinoma,HCC），是世界上最常见的恶性肿瘤之一，具有高度恶性、血供丰富、生长迅速及起病相对隐匿等特点。作为富血管实体瘤，HCC的主要特征是肿瘤细胞失控性增殖导致肿瘤内缺氧微环境的形成，促进新生血管生成，从而促进肿瘤生长。 姜黄素是从草本姜科植物姜黄的根茎中提取出来的一种脂溶性酚类色素，具有抗氧化、抗炎、抗凝、降脂、抗动脉粥样硬化、抗肿瘤、抗血管生成、保护肝功能及抗衰老消除自由基等广泛药理作用。姜黄素具有抗癌谱广、毒副作用小及价格低廉的优点 ...
陈艺辉
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