Results 11 to 20 of about 24,587 (167)
早期慢性肾脏病患者体内血清白蛋白水平对冠脉钙化的预测价值 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban目的探讨早期慢性肾脏病（CKD）患者的血清白蛋白水平与冠脉钙化（CAC）的相关性，以及对CAC发生及严重程度的预测价值。方法筛选2019年1月至2022年12月于中山大学孙逸仙纪念医院住院行冠状动脉CTA检查的早期CKD患者391例，收集一般临床资料、血清学检查结果、冠脉CTA检查结果。根据冠脉钙化积分（CACS）将患者分为非冠脉钙化组（CACS=0分）184例，冠脉钙化组（CACS>0分）207例；根据血清白蛋白水平分为三组，即白蛋白<35 g/L组（30例）、35 g/L≤白蛋白< ...
麦培彪 +4 more
doaj +3 more sources
UVA Assisted 4-Thiothymidine for Cancer Treatment [PDF]
, 2016 This article reviews the developments of 4-thiothymidine analogues, assisted with UVA light, as a novel cancer therapy. First, the key points on synthetic chemistry, photochemistry and cellular toxicity of 4-thiothymidine are summarized.
Feng, Luo +3 more
core +1 more source
Study on the interactions of typical PAHs and their metabolites with serum albumin and their controlling ways using cyclodextrins [PDF]
, 2016 血清白蛋白是血浆中含量最丰富的运输蛋白，对血液中许多内、外源物质具有广普的结合能力，具有重要的生理功能。多环芳烃（PolycyclicAromaticHydrocarbons，PAHs）及其代谢物可与血清白蛋白形成稳定的加合物，由此随血液循环转运分布至各组织器官，引起毒性效应。该结合过程也可对血清白蛋白的结构和功能产生不利影响。因此，深入研究PAHs及其代谢物与血清白蛋白的结合作用，探究PAHs对血清白蛋白结构和功能的影响及寻求该结合作用的调控方式对了解PAHs在生物体内的赋存状态、毒性强度及致毒机制 ...
张静
core
Veterinary Dermatology, Volume 37, Issue 2, Page 306-318, April 2026.Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova +6 more
wiley +1 more source
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang +7 more
wiley +1 more source
Quantitative analysis of protein-protein interaction in BACTH system using flow cytometry [PDF]
, 2016 蛋白-蛋白相互作用是所有生命活动的基础，其研究有助于人们更好地理解蛋白质功能、构建相互作用网络、发现药物靶点、发展疾病诊断和治疗的方法。现有的蛋白-蛋白相互作用研究方法主要分为体外检测和体内检测两种。等温滴定量热法、表面等离子体共振法、荧光偏振法等是常用的体外检测方法，这类方法往往需要使用昂贵的仪器检测以及繁琐的蛋白纯化与标记过程；而酵母双杂交、蛋白质片段重组、合成致死等体内检测方法则只需在细胞和基因水平操作，不仅省去了蛋白质纯化步骤，而且能够真实地反映蛋白质在细胞中的相互作用情况。其中 ...
汪旭
core
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT This study introduces novel nonequiatomic TiZrCoCrMoCux (x = 0, 5, 10; at%) medium‐entropy alloys (MEAx) tailored for orthopedic implants, synergistically combining the biocompatibility of Ti‐based alloys, the wear resistance of CoCrMo alloys, and the antibacterial/osteogenic attributes of Cu. The alloy's microstructure, mechanical properties,
Hang Yu +9 more
wiley +1 more source
The effect of pentosan polysulfate on diabetic nephropathy renal tubular epithelial cells injury through regulating p38 MAPK signaling pathway [PDF]
, 2016 目的：观察戊糖多硫酸钠是否通过调控P38MAPK干预糖尿病肾病肾小管上皮细胞的损伤。方法：利用不同浓度（10mmol/L～50mmol/L）葡萄糖刺激肾小管上皮细胞（HK-2）48h，应用CCK-8比色法检测肾小管上皮细胞增殖的改变。利用不同时间段（0h～48h）葡萄糖刺激细胞，用Westernblot法检测P38MAPK蛋白的表达水平。分为正常对照组（control组）、高糖组（HG组，葡萄糖30mmol/L)、戊糖多硫酸钠（PPS）组（PPS200µg/mL)、高糖＋戊糖多硫酸钠组（HG＋
张天英
core
SWEET1‐mediated glucose transport is crucial for energy availability in Arabidopsis
New Phytologist, Volume 249, Issue 4, Page 1816-1830, February 2026.Summary The stress‐responsive hormone abscisic acid (ABA) is known for its inhibitory effects on various physiological processes, including seed germination, often resulting in energy deprivation. Interestingly, ABA‐induced germination inhibition can be alleviated by exogenous glucose (Glc), mimicking a functional interplay between ABA and sugar ...
Xueyi Xue +3 more
wiley +1 more source
PET Imaging and Targeted Radiotherapy of Integrin αvβ3 Positive Tumors [PDF]
, 2016 目的：含有三肽序列的精氨酸-甘氨酸-天冬氨酸（Arg-Gly-Asp，RGD）的配体和整合素αvβ3具有特异性和高亲和力，因此利用RGD与整合素αvβ3特异性结合而设计的放射性核素标记的RGD分子探针在肿瘤显像方面得到了广泛的研究和应用。然而，放射性核素标记的RGD分子探针在肿瘤治疗方面的研究却并不多。本研究中，我们创造性的将环状多肽RGDfK与白蛋白结合基团伊文思蓝（EvansBlue，EB）共价结合，以期构建一种可长时间存在于体内循环的长效分子探针EB-RGD ...
陈皓鋆
core