Mechanism study of KCMF1 promoting proliferation and NF-κB signaling transduction in colorectal cancer cells [PDF]
Background and purpose: Colorectal cancer (CRC) is one of the major malignant tumors threatening human health worldwide, with long-term high incidence and mortality rate.
WU Zhibai, XU Guiqin, ZHANG Li, YANG Zhaojuan, LIU Yun, JIAO Kun, CHEN Zehong, XU Chen, ZUO You, ZHENG Ningqian, YE Zhiqian, LIU Yongzhong
core +1 more source
Interaction between ferritin light chain(FTL) and PEN2 [PDF]
, 2011 阿尔茨海默氏疾病（Alzheimer’sdisease，AD）是一种与年龄密切相关的神经退行性疾病，具有两大病理特征：由过磷酸化tau蛋白组成的神经元纤维缠结和由β-淀粉样蛋白（Aβ）组成的淀粉样斑。Aβ是由β-分泌酶和γ-分泌酶对β-淀粉样前体蛋白（amyloidprecursorprotein，APP）顺序剪切后所产生，在AD的发病过程中起着重要作用。γ-分泌酶复合体主要由早老素(presenilin，PS)、APH1、PEN2、Nicastrin四种蛋白组分构成，这四种组分便可以形成有活性的γ ...
李欣欣
core
Optimization study of CAR-T cell expansion targeting CD99 [PDF]
Background and purpose: Chimeric antigen receptor T (CAR-T) cell therapy has shown remarkable efficacy in treating hematological and lymphatic system tumors, but its effectiveness in solid tumors is relatively poor, which is partly attributed to target ...
WANG Yixuan, YU Miao, ZHAO Jiaxuan, ZHAO Fenfang, ZENG Yi, WANG Youyong, ZHU Haichuan, ZHANG Tongcun, SHI Jiangzhou
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KHSRP regulates the responsiveness of prostate cancer cells to androgens through ANK3 [PDF]
Objective·To investigate the impact of KH-type splicing regulatory protein (KHSRP) on the proliferation of prostate cancer cells and the regulation of downstream gene expression, and explore the potential role and mechanism of KHSRP in the transition of ...
CAI Renjie, XU Ming
core +1 more source
Small interfering RNA mediated multi-target therapy of cancer [PDF]
, 2009 : It has been reviewed that as many as hundreds genes are dysregulated in various kinds of cancers, yet most therapies are targeted toward a single gene.
Rong-Guang Shao
core
慢病毒介导shRNA抑制垂体腺瘤PTTG基因表达及对细胞增殖和侵袭能力的影响
Zhongshan Daxue xuebao. Yixue kexue ban, 2016 摘 要: 【目的】 观察慢病毒介导的shRNA对GH3和AtT20型垂体腺瘤中垂体肿瘤转化基因(PTTG)表达的抑制作用,以及对肿瘤细胞增殖和侵袭能力的影响及其机制探讨?【方法】 筛选最佳抑制效果的干扰序列构建PTTG基因shRNA的慢病毒表达载体,转染GH3和AtT20型垂体腺瘤细胞?流式细胞仪分析细胞转染效率,RT-PCR和Western blot检测细胞PTTG基因mRNA和蛋白的表达水平,MTT和EdU法分别检测靶向PTTG的shRNA对肿瘤细胞增殖生长的抑制作用,流式细胞仪检测细胞周期变化 ...
doaj
Knock-down of VEGF expression by siRNA in zebrafish embryos
, 2007 运用RNA干扰技术,针对斑马鱼血管内皮生长因子(VEGF)基因设计并合成了特异性小分子干扰RNA(siRNA),并从血管形成水平研究了siRNA对VEGF基因表达的影响.为了得到能在体内稳定表达的siRNA,进一步以pSilencer 4.1-CMV Vector为载体,合成了短发夹RNA (shRNA)表达模板并定向克隆到CMV启动子下游,构建了shRNA表达载体.定量碱性磷酸酶染色显示注射合成的siRNA后胚胎新血管生成(angiogenesis)为71.8%,NBT ...
杨少丽 +4 more
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Effect of circPUM1 on radioresistance of cervical cancer cells through targeting miR-144-3p. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue Ban, 2022 Hu B, Yuan J.
europepmc +1 more source
[cGAS-STING agonist cGAMP enhances natural killer cell-mediated cytotoxicity against gastric cancer cells]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoWang Q +6 more
europepmc +1 more source
[Research progress on external cervical resorption]. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue BanChen R +5 more
europepmc +1 more source