[The miR-30b/USP14 axis regulates mitophagy via a non-PINK1/Parkin pathway in neuronal oxygen-glucose deprivation/reoxygenation injury]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiBei YH, Yu K, Wang X.
europepmc +1 more source
[Gastrodin inhibits ferroptosis to alleviate hypoxic-ischemic brain damage in neonatal mice by activating GPX4/SLC7A11/FTH1 signaling]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoGuo T +8 more
europepmc +1 more source
Zhongshan Daxue xuebao. Yixue kexue banβ淀粉样蛋白（Aβ）被认为是阿尔茨海默病（AD）的主要致病因素之一。然而，近年研究表明，Aβ可激活小胶质细胞和星形胶质细胞，引发神经炎症反应。神经炎症在神经元死亡过程中起关键作用，并可视为AD发生的深层机制。此外，早在20多年前便有学者提出脑血管损伤在AD发病机制中具有重要作用，但较少有研究关注其积极意义。近年来，越来越多证据表明脑微血管损伤会促使AD发生。最新研究还指出，脑微血管损伤引发的炎症同样是AD发展的重要风险因素。在受损的微血管中，C反应蛋白（CRP）是一种非特异性炎症标志物 ...
张洁, 朱益宜
doaj
[Therapeutic potential of extracellular vesicles in neurological diseases]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoDU Q, Yang C, Xia X, Wang T.
europepmc +1 more source
[Analysis of induction therapy response in children with high-risk neuroblastoma]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiWang Y +6 more
europepmc +1 more source
[Underlying Mechanism of the circ_0011462/miRNA-1200/SP1 Axis in Regulating Inflammatory Response, Apoptosis, and Neural Regeneration in a Spinal Cord Injury Model]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanLi M +5 more
europepmc +1 more source
β-淀粉样肽对海马 CA1 区神经元的 短暂性外向 K+电流的影响
Zhongshan Daxue xuebao. Yixue kexue ban, 1998 目的: 为了在离子通道水平探讨β-淀粉样肽( β-AP)在 Alzheimer 病中的作用。方法: 用 7～ 21 d 大鼠,以链霉蛋 白酶 E 酶解加吸管吹打法制备海马 CA1区神经元; 利用全细胞膜片钳技术, 观察了β-AP25～ 35对急性分离海马 CA1 区锥体细 胞的短暂性 K+电流的影响。结果: β-AP25～ 35对短暂性 K+电流有明显抑制作用, 且呈明显浓度依赖性、时间依赖性和部分电 压依赖性。结论: β-AP 对 K+通道的影响在 Alzheimer 病的发生机制中具有重要作用 ...
doaj
[Extracellular matrix materials and tissue regeneration and repair]. [PDF]
Zhongguo Xiu Fu Chong Jian Wai Ke Za ZhiZhao L, Xie H.
europepmc +1 more source
[Mother-to-Child Transmission of Chikungunya Virus and Its Impact on the Neonatal Nervous System]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanLuo K, Tang J.
europepmc +1 more source