[Association Between T Lymphocyte Mitochondrial Function and Disease Activity in Anti-NMDAR Encephalitis]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanMa Y +7 more
europepmc +1 more source
Zhongshan Daxue xuebao. Yixue kexue banβ淀粉样蛋白（Aβ）被认为是阿尔茨海默病（AD）的主要致病因素之一。然而，近年研究表明，Aβ可激活小胶质细胞和星形胶质细胞，引发神经炎症反应。神经炎症在神经元死亡过程中起关键作用，并可视为AD发生的深层机制。此外，早在20多年前便有学者提出脑血管损伤在AD发病机制中具有重要作用，但较少有研究关注其积极意义。近年来，越来越多证据表明脑微血管损伤会促使AD发生。最新研究还指出，脑微血管损伤引发的炎症同样是AD发展的重要风险因素。在受损的微血管中，C反应蛋白（CRP）是一种非特异性炎症标志物 ...
张洁, 朱益宜
doaj
[Kahweol improves motor function of mice with spinal cord injury by inhibiting microglial activation <i>via</i> regulating the IκBα/NF-κB pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoXia J +6 more
europepmc +1 more source
[Research progress on the causes of pain in knee osteoarthritis]. [PDF]
Zhongguo Xiu Fu Chong Jian Wai Ke Za ZhiWei N, Zheng Z.
europepmc +1 more source
β-淀粉样肽对海马 CA1 区神经元的 短暂性外向 K+电流的影响
Zhongshan Daxue xuebao. Yixue kexue ban, 1998 目的: 为了在离子通道水平探讨β-淀粉样肽( β-AP)在 Alzheimer 病中的作用。方法: 用 7～ 21 d 大鼠,以链霉蛋 白酶 E 酶解加吸管吹打法制备海马 CA1区神经元; 利用全细胞膜片钳技术, 观察了β-AP25～ 35对急性分离海马 CA1 区锥体细 胞的短暂性 K+电流的影响。结果: β-AP25～ 35对短暂性 K+电流有明显抑制作用, 且呈明显浓度依赖性、时间依赖性和部分电 压依赖性。结论: β-AP 对 K+通道的影响在 Alzheimer 病的发生机制中具有重要作用 ...
doaj
[Adeno-associated virus-mediated gene therapy for genetic epilepsy: prospects and challenges]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiSun B, Wang XL, Peng J.
europepmc +1 more source
[Plasma metabolites mediates the causal effect of inflammatory proteins on Alzheimer's disease: a Mendelian randomization study]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoChen M, Huang R, Yang Z.
europepmc +1 more source
[The role and mechanism of chemokine network in promoting osteoarthritis progression by regulating synovial macrophage heterogeneity]. [PDF]
Zhongguo Xiu Fu Chong Jian Wai Ke Za ZhiLin Y, Wu L, Chen Q, Shen B.
europepmc +1 more source
[Role of dysregulation brain lipid metabolism in depression]. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue BanYu P, Huang S, Jiang Z, Wang X, Jiang D.
europepmc +1 more source