Recent advances and prospect in immune microenvironment and its mechanisms of function in head and neck squamous cell carcinoma [PDF]
, 2023 Head and neck cancer (HNC) remains a significant cause of morbidity and mortality. The most prevalent pathology among HNC is head and neck squamous cell carcinoma (HNSCC).
ZHANG Shaoqiu, YAN Li, LI Ruichen, ZHAO Yang, WANG Xiaoshen, YANG Xuguang, ZHU Yi
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Research Progress on Immunomodulatory Activity of Polysaccharides from Blue Foods [PDF]
, 2023 With the current over-exploitation of terrestrial resources, multi-dimensional in-depth utilization of aquatic resources has attracted widespread attention.
GU Fudie, ZHOU Yu, CHEN Huiying, LIU Wenmei, ZOU Zehua, LIU Guangming, LIU Qingmei
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, 2018 妊娠第37周前分娩的现象被称为早产。目前,全球每年约有1500万早产儿出生,其中100万早产儿在出生后的1个月内死亡。因此,早产作为一个全球性的问题,为社会带来了严重的负担。探索早产发生的机制,寻找有效的预防方法,是目前亟待解决的科学问题。文章围绕影响母胎界面微环境的3个主要因素即胎儿滋养层细胞、子宫蜕膜和母胎界面免疫细胞,详细阐述母胎界面微环境改变在早产发生中的作用机制。国家重点研发计划 ...
孟楠, 张思亚, 王海滨, 黄琳
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Development of interleukin-21 as a therapeutic drug [PDF]
, 2017 白细胞介素21; (IL-21)是一种具有多效免疫调节活性的细胞因子,参与先天性免疫反应和适应性免疫反应的多个环节,与自身免疫性疾病、肿瘤、病毒感染等疾病的发病过; 程相关。研究表明,在动物模型中通过增强或抑制IL-21的生物学功能对多种疾病具有治疗意义,多项以重组人IL-21为受试药物的临床试验已经开展。本; 文就IL-21的生物学功能,以及IL-21作为生化药物在临床治疗中的研究进展和应用前景进行阐述。Interleukin-21 (IL-21) is a cytokine with broad ...
刘狄彤 +5 more
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Progresses on immune-related genes and proteins of abalones [PDF]
, 2009 鲍是世界重要的海水养殖经济贝类,但近年来时常发生的疾病给养鲍业带来了大量的经济损失。目前有关鲍免疫相关基因和蛋白的研究报道较少,而这些功能分子对揭示鲍的免疫机制具有关键作用,文章综述了鲍免疫相关基因和蛋白的研究进展,以期为防治鲍疾病的相关研究提供参考。Abalones, belonging to one of the largest marine gastropod mollusks, are economically important seafood in aquaculture worldwide.
任洪林, 柳增善, 王克坚
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Advances in fundamental and translational breast cancer research in 2022 [PDF]
, 2023 According to the data released by the International Cancer Research Institute of the World Health Organization (WHO), breast cancer is the malignant tumor with the highest incidence rate in women, and seriously endangers women's health.Many impressive ...
WANG Ziyu, XIAO Yi, JIANG Yizhou, SHAO Zhimin
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Advances in Mechanism of Coexistence and Pharmaceutical Treatment of Chronic Heart Failure and Depression [PDF]
, 2022 The coprevalence of chronic heart failure (CHF) and depression is 10%-79%, the pathogenesis of these two diseases is related to the activation of immune inflammatory system, insulin resistance and intestinal flora imbalance, and relevant regulation is ...
YANG Rongjun, SHI Yufang, WANG Qinghai
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The Systemic Evaluation and Clinical Significance of Immunological Function for Advanced Lung Cancer Patients [PDF]
, 2010 Background and objective The actual evaluation of immunological function is significant for studing the tumor development and devising a treatment in time.
Hui ZHANG +12 more
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Thalidomide combined with co-stimulatory molecules blockade prolongs survival of cardiac allografts in alloantigen-primed mice [PDF]
, 2015 目的：体内预存的各种记忆细胞是器官移植中的重要障碍。记忆细胞对侵入的病原体产生强烈的免疫反应，但同时会导致移植物发生排斥。研究发现，沙利度胺在初次器官移植中具有抑制免疫排斥反应的作用，但其作用机制仍不明确。沙利度胺在器官移植中的潜在作用，很有可能使其成为作用于新靶点、高效低毒的免疫抑制剂。这里，我们拟研究沙利度胺联合共刺激分子阻断剂对皮肤预致敏小鼠心脏移植物生存期的作用，并探讨其在免疫记忆中的作用机制。 方法：首先通过同种异体皮肤移植得到预致敏小鼠，然后随机将皮肤预致敏小鼠分成4组，每组6只。对照组 ...
朱茂述
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血管内皮生长因子表达与肝癌患者临床病理特征及预后的关系研究 [PDF]
, 2018 目的:研究肝细胞肝癌(HCC)组织中血管内皮生长因子(VEGF)表达与患者临床病理特征及预后的关系。方法:采用免疫组织化学染色法检测79例在广西医科大学附属肿瘤医院行肝癌根治性切除术的HCC患者癌组织中VEGF的表达情况,分析VEGF表达与树突状细胞(DC)浸润程度、肿瘤大小、癌栓、包膜、血清AFP水平及术后肝外转移的关系,随访患者术后生存情况及肿瘤复发情况。结果:79例HCC患者中,VEGF低表达43例(54.4%),高表达36例(45.6%)。VEGF表达与DC浸润程度、肿瘤直径及血清AFP水平有关(
张义 +4 more
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