[Application of percutaneous endoscopic gastrostomy in children with methylmalonic acidemia or propionic acidemia complicated by feeding difficulties: a case series of 7 patients]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiLi WY +10 more
europepmc +1 more source
The synergistic anticancer effect of Lipo-Dox and perforin on colon cancer cell, CT26
[[abstract]]穿孔素是一種經由活化態細胞毒殺型T淋巴球及自然殺手細胞所表現的分泌型蛋白質。穿孔素在毒殺細胞的機制中為一重要的物質，其作用為插入目標細胞之細胞膜並在細胞表面形成孔洞，造成細胞傷害。在先前的研究中，我們探討利用穿孔素配合抗癌藥物Doxorubicin的協同效用對於毒殺癌細胞的可能性。穿孔素表現載體經由CMV啟動子所驅動，並將表現載體轉染至小鼠大腸癌細胞株，CT26。透過MTT分析的方式評估不同表現載體穿孔素毒殺效率 ...
Li, Yan-Qing, 李彥慶
core
[Performance validation and consistency assessment of three liquid chromatography-tandem mass spectrometry methods for detecting fat-soluble vitamins]. [PDF]
Se PuLi BC +8 more
europepmc +1 more source
Perforin Expression Driven by Survivin Promoter Inhibits Tumor Growth
[[abstract]]生存蛋白在成熟的正常組織表現低落，但卻廣泛地、大量地表現於癌細胞中，為著名的IAP (Inhibitor of Apoptosis Protein) 家族成員之一。功能歸納出有三類，分別是抑制細胞凋亡、參與細胞分裂和抗藥性的產生。因為生存蛋白幾乎不在正常細胞表現，已有許多研究利用位於生存蛋白基因上游的啟動子進行基因治療。在生存素啟動子下游接上可對癌細胞產生細胞毒性的蛋白之基因，然後將此載體送入癌細胞內，使細胞大量表現此一蛋白質，而達到抑癌的結果。 穿孔素為細胞內重要的毒殺蛋白 ...
Chu, Ying-rui, 朱映瑞
core
[Exploration and application of nanotechnology in precision transarterial chemoembolization for hepatocellular carcinoma]. [PDF]
Zhonghua Gan Zang Bing Za ZhiKong JQ +5 more
europepmc +1 more source
[Effectiveness comparison of transforaminal endoscopy and unilateral biportal endoscopy for far lateral lumbar disc herniation]. [PDF]
Zhongguo Xiu Fu Chong Jian Wai Ke Za ZhiZhang J +6 more
europepmc +1 more source
[Screening of High-quality Spermatozoa Using Transwell Membrane Pores and Assessment of Their Performance]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanLi Y +7 more
europepmc +1 more source
[Recent advances in artificial intelligence for auxiliary diagnosis and management of neonatal necrotizing enterocolitis]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiJiang Q, Zhang L.
europepmc +1 more source
[Effect of Golgi membrane protein 1 on the proliferation, migration, and invasion of oral squamous cell carcinoma cells and its mechanism]. [PDF]
Hua Xi Kou Qiang Yi Xue Za ZhiLi S, Wen C, Yu L, Chen J, Feng H.
europepmc +1 more source
[Medical treatment standards for emergency trauma wounded (2025 edition)]. [PDF]
Zhongguo Xiu Fu Chong Jian Wai Ke Za ZhiNational Health Commission Of The People's Republic Of China.
europepmc +1 more source