Results 41 to 50 of about 197,693 (195)
Zhongguo shiyan zhenduanxue, 2011 目的探讨K-ras基因突变谱与结直肠癌肝转移的相关性,为进一步阐明结直肠癌肝转移的分子机制提供理论依据。方法收集2008年1月至2010年8月在我院治疗的结直肠癌肝转移患者30例,进行K-ras基因突变检测,分析K-ras基因的突变类型及频率,探讨K-ras基因的突变谱与结直肠癌肝转移患者性别、年龄、原发灶位置、转移位置、病灶形态及TNM分期的相关性。结果 30例结直肠癌肝转移患者组织中K-ras基因突变者14例,突变率为47%,其中12密码子突变9例,突变率为30%;13密码子突变者5例,突变率为17%
王涛 +4 more
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Conservation Biology, Volume 40, Issue 5, October 2026.Abstract The International Union for Conservation of Nature (IUCN) Red List of Threatened Species is a critical measure of global aquatic and terrestrial biodiversity status. It is also the basis for the Red List Index, which tracks extinction risk over time.
Brittany Finucci +10 more
wiley +1 more source
Rare Metals, Volume 45, Issue 9, September 2026.ABSTRACT Conductive hydrogels show great potential in flexible electronics and biomedical devices, yet their practical applications are often hindered by insufficient mechanical strength, poor environmental stability, and limited functionality. To address these challenges, this study has developed a hydrogel platform that integrates diagnosis and ...
Wei Jiang +9 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2021 目的探讨肝硬化患者血浆游离DNA(cfDNA)中TERT基因-124(C/T)和-146(C/T)热点突变率及其突变与临床指标相关性。方法纳入航天中心医院2019年10月-2020年11月肝硬化患者80例,收集患者临床基本资料。EDTA抗凝全血分离500μL血浆提取cfDNA。TERT热点突变检测采用ARMS-qPCR方法。结果在80例肝硬化患者血浆cfDNA中,检测到TERT热点突变6例(7.5%),其中-124(C/T)4例(5%),-146(C/T)2例(2.5%)。与非突变组比较 ...
薛晓霞, 何美琳, 梁国威
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亚洲临床医学杂志, 2020 目的： 观察和分析亲子鉴定案例中常染色体 STR 基因座的突变特征与规律情况。 方法： 选择 AGCU EX22 荧光检测试剂盒检测的案件 942 例，筛选该试剂盒 21 个常染色体STR 基因座的突变事件，判断突变等位基因的来源，统计各基因座的突变率，分析突变的特点。 结果： 942 例亲子鉴定中双亲鉴定有 317 例，单亲鉴定有 625 例，结论为“支持”的共有 865 例。在结论为“支持”的案例中统计到 27 例有 STR 基因座发生突变， 16 个基因座有突变现象发生，突变率在 0.0859% ～
Yun-Rong Qin
semanticscholar +1 more source
Accessing Ultra‐Nano Phase‐Separated Metallic Glasses via Cryogenic Cycling
Rare Metals, Volume 45, Issue 9, September 2026.ABSTRACT Phase separation offers a promising avenue to mitigate the inherent brittleness of metallic glasses. However, traditional approaches relying on mixing enthalpy face significant challenges, primarily due to the detrimental impact on glass‐forming ability.
Huaping Ding +15 more
wiley +1 more source
Rare Metals, Volume 45, Issue 9, September 2026.ABSTRACT Platinum‐based electrocatalysts are fundamentally constrained by strong oxygen binding, which restricts the oxygen reduction reaction (ORR) kinetics, and by severe CO poisoning, which hinders the methanol oxidation reaction (MOR). To address these limitations, we synthesized PdPtRuIrRhNi high‐entropy alloy (HEA) mesoporous nanotubes that ...
Hong Pan +6 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2012 目的对已明确基因突变的轻型β-珠蛋白生成障碍性贫血患者的红细胞参数进行比较分析,探讨β-珠蛋白基因的突变类型与红细胞参数的相关性。方法分析118例已知基因突变的轻型β-珠蛋白生成障碍性贫血患者的红细胞平均容积、红细胞平均血红蛋白含量、红细胞平均血红蛋白浓度、红细胞体积分布宽度标准差、红细胞体积分布宽度变异系数,对这些参数依据突变类型进行比较。结果在已知β-珠蛋白基因突变中,携带codon41/42（-TTCT）突变的患者红细胞平均容积、红细胞平均血红蛋白含量及红细胞平均血红蛋白浓度高于其它突变患者 ...
彭运生 +4 more
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Concurrent Crises and Non‐State Service Provision
Risk, Hazards &Crisis in Public Policy, Volume 17, Issue 3, September 2026.ABSTRACT Concurrent crises represent a significant challenge for disaster and public health governance. Activated in response to one threat, governing institutions may be distracted or stretched thin during an emergent crisis. In such crises, governments and communities rely heavily on non‐state service providers such as non‐profit organizations and ...
Daniel Sledge, Herschel F. Thomas
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2003 目的 探讨 10例遗传性凝血因子Ⅶ （coagulationfactorⅦ ,FⅦ ）缺陷症基因突变类型与临床特性。方法 检测凝血指标以明确诊断 ;用DNA直接测序法对先证者及其家庭成员FⅦ基因的全部外显子及其侧翼、5’和 3’非翻译区进行分析 ,寻找基因突变 ;将含插入或缺失突变序列克隆入pMD18 TTA克隆载体中 ,对所得两条染色体相应序列分别测序 ,以确定突变在染色体上的分布。应用限制性内切酶对先证者及家系成员相应基因片段进行酶切分析 ,无酶切位点改变的基因片段用等位基因特异的PCR（ASPCR）
丁秋兰 +7 more
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