【目的】 采用RNA干扰(RNAi)技术阻断类风湿关节炎(RA)成纤维样滑膜细胞(FLS)尿激酶型纤溶酶原激活物受体(uPAR)基因的表达,探讨uPAR基因沉默后对RA-FLS功能产生的影响及有关机制?【方法】 收集行关节置换术或滑膜清理术的RA患者的滑膜组织,组织块法培养RA-FLS?通过阳离子脂质体转染的方法,转染体外合成的特异性uPAR-siRNA;利用荧光定量PCR法和Western blotting法检测uPAR沉默效果;CCK8法检测细胞增殖抑制率;流式细胞技术检测细胞周期改变 ...
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[Cheng's Juanbi Decoction Inhibits Rheumatoid Arthritis Pathology by Blocking the WTAP-Wnt7b-Wnt/β-Catenin Signaling Axis]. [PDF]
Wu Y +8 more
europepmc +1 more source
[Bioinformatics analysis of oxidative stress and immune infiltration in rheumatoid arthritis]. [PDF]
Gao Z, Wu A, Hu Z, Sun P.
europepmc +1 more source
[Treatment of rheumatoid arthritis of wrist using Ilizarov wrist joint distraction technique: a case report]. [PDF]
Wang B, Gao G, Huo Y, Yang H, Jiang J.
europepmc +1 more source
[Research progress on the role of dendritic cells in immune metabolism of rheumatoid arthritis]. [PDF]
Han G, Sun S, Wang Q, Kang P.
europepmc +1 more source
[Identification of high-risk preoperative blood indicators and baseline characteristics for multiple postoperative complications in rheumatoid arthritis patients undergoing total knee arthroplasty: a multi-machine learning feature contribution analysis]. [PDF]
Zhu K +6 more
europepmc +1 more source
[Qianggu Kangshu Formula attenuates osteoclast differentiation in rheumatoid arthritis by inhibiting the HIF-1α/BNIP3 autophagy signaling pathway]. [PDF]
Li W +6 more
europepmc +1 more source
以三江平原典型环形湿地为研究对象,在小叶章群落、沼柳小叶章群落、漂茷苔草群落、塔头毛苔草群落,采用黄盘诱集法和扫网法定期对湿地昆虫群落进行采集,研究了该区内的昆虫生物多样性及其季节性变化特征。共采集昆虫标本25945号,其中双翅目和同翅目数量最多,其次为膜翅目、缨翅目、弹尾目、鞘翅目、半翅目、直翅目等。各个植物群落昆虫种群的数量,Shannon-Wiener指数、Pielou指数受季节性影响显著。6月下旬湿地昆虫数量最多,但是Shannon-Wiener指数,Pielou指数最低。Shannon ...
暴晓, 张帆, 吕宪国
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检测抗核抗体早期诊断类风湿郭巍王守芹聂德志孙红艳郑宏图四平市中心医院136000靳树仁青岛市第八人民医院心外科应用免疫荧光技术测定血清中抗核抗体(ANA)对诊断胶原系统疾病特别是系统性红斑狼疮、硬皮病等具有重要价值,但对其诊断类风湿性关节炎(RA)阳...
doaj
[Tujia medicine Toddalia asiatica improves synovial pannus in rats with collagen-induced arthritis through the PI3K/Akt signaling pathway]. [PDF]
Xiang S +8 more
europepmc +1 more source

