Results 121 to 130 of about 5,918 (167)

SRC激酶调控肿瘤糖代谢的研究进展

Zhongshan Daxue xuebao. Yixue kexue ban
SRC激酶是一种与膜相关的非受体酪氨酸激酶，在细胞生长、分裂、迁移和存活信号通路中发挥着重要作用。此外，它还通过不同机制调节癌细胞中的葡萄糖代谢，如直接调节葡萄糖代谢相关酶和葡萄糖转运体，或间接调节相关信号转导通路等。在这篇综述中，我们阐明了SRC激酶在调控癌细胞葡萄糖代谢中的作用，还讨论了以SRC为靶点的各种抑制剂的研究进展与存在问题，探讨研发更高选择性和更高活性的SRC抑制剂，使靶向SRC成为治疗肿瘤的新希望。
龚玉雯, 王志平
doaj  

Research progress on the relationship between Nesfatin-1 and glucose metabolism. [PDF]

Zhong Nan Da Xue Xue Bao Yi Xue Ban
Cao Y, Wang W.
europepmc   +1 more source

[Salidroside inhibits proliferation of gastric cancer cells by regulating the miR-1343-3p-OGDHL/PDHB glucose metabolic axis]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Hou X, Zhang Z, Cao M, DU Y, Wang X.
europepmc   +1 more source

支链氨基酸代谢障碍介导巨噬细胞促炎反应加重糖尿病脓毒症后心肺损伤

Zhongguo shiyan zhenduanxue
目的探究糖尿病相关的支链氨基酸（branched-chain amino acid,BCAA）代谢障碍对糖尿病并发脓毒症后心肺损伤的影响及其机制。方法利用糖尿病患者及糖尿病模型小鼠，检测血浆BCAA水平、外周血单个核细胞（peripheral blood mononuclear cells,PBMCs）及小鼠骨髓来源巨噬细胞（bone marrow primary macrophages,BMDMs）中BCAA 代谢关键酶Mg2+/Mn2+依赖型蛋白磷酸酶1K（Protein Phosphatase ...
罗凯腾, 谢茂迪, 杨为, 刘君竹, 李涛, 胡国昌, 周莉, 姜春玲   +7 more
doaj  

[Research progress on lactylation modification in pathogenesis of osteoarthritis]. [PDF]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Wu Y, Sun K, Ding Y, Li M, Liu Y, Wu L, Peng L, Shen B.   +7 more
europepmc   +1 more source

[<i>Jiangzhi Quban</i> Recipe improves type 2 diabetes mellitus complicated with hyperlipidemia by multi-target regulation of the inflammation-metabolism network: network pharmacology analysis and clinical validation]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Li Z, Zhou F, Sun X, Zhao H, Jin Y, He P, Jia Y.   +6 more
europepmc   +1 more source

[Progress in metabolomics of multiple myeloma]. [PDF]

Zhonghua Xue Ye Xue Za Zhi
Ye X, Sun ZX, Qu XY, Fan L.
europepmc   +1 more source

高原低氧环境抑制小鼠脾脏组织碳代谢的分子机制

Zhongshan Daxue xuebao. Yixue kexue ban
目的探究低氧暴露对小鼠脾脏组织碳代谢通路的调控机制。方法将C57BL/6小鼠分别在海拔400 m和4 200 m饲养，每组5只，30 d后无菌取出脾脏组织，通过转录组测序，蛋白质组学和非靶向代谢组学分析差异表达基因、差异蛋白以及差异代谢物，利用GO和KEGG富集分析，挖掘关键通路，并通过RT-qPCR和Western blot对通路中关键基因和蛋白进行验证。结果转录组测序发现，低氧暴露下有4 213个基因出现显著性差异表达，其中1 947个基因表达上调，2 266个基因表达下调 ...
陈晓晨, 胡英, 许玉珍, 龙启福, 马茹雪, 永胜   +5 more
doaj  

[Traditional Chinese medicine for regulating glycolysis to remodel the tumor immune microenvironment: research progress and future prospects]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
He S, Liu Y, Qin M, He C, Jiang W, Wang Y, Tan S, Sun H, Sun H.   +8 more
europepmc   +1 more source

[Research progress on cellular metabolic reprogramming in skin fibrosis]. [PDF]

Zhejiang Da Xue Xue Bao Yi Xue Ban
Qian S, Dai S, Guo C, Xu J.
europepmc   +1 more source