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人脐带间充质干细胞通过 IGF1R-CHK2-p53 信号轴减轻 2 型糖尿病雄性大鼠糖尿病肾病 [PDF]
J Zhejiang Univ Sci BHao Zhang +16 more
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慢性肾脏病3-4期糖尿病肾脏疾病患者进展到终末期肾病的危险因素分类树模型分析 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2019 【目的】分析糖尿病肾脏疾病（DKD）患者进展到终末期肾病（ESRD）的相关危险因素，筛查进展到ESRD的高风险人群，以早期预防。【方法】收集本院231例糖尿病肾脏疾病患者的临床资料，随访3年，据是否出现ESRD分为未进展到ESRD（133例）、ESRD组（98例）。使用分类树模型分析进展到ESRD相关危险因素，通过节点增益分析筛选进展到ESRD的高风险人群。【结果】从预测变量中筛选到4个重要解释变量：载脂蛋B（ApoB）、性别、糖尿病视网膜病变、收缩压；ApoB升高是DKD进展的重要的危险因素；ApoB＞
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中西医结合护理, 2021 Objective To understand the incidence of hypoglycemia in patients with diabetic nephropathy(DN)or non-DN during hemodialysis and explore whether there is a difference in the degree of fear of hypoglycemia and depression between DN and non-DN patients on ...
JIA Wanning (贾婉宁) +4 more
doaj +1 more source
Research progress of risk factors and nursing of diabetic nephropathy (糖尿病肾病患者危险因素及护理进展)
中西医结合护理, 2023 Diabetic nephropathy is one of the common microvascular complications in patients with diabetes, which is difficult to treat clinically, and is also a common cause of end-stage renal failure.
LI Shanshan (李珊珊) +1 more
doaj +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2004 【目的】分析肾活检诊断明确的原发性慢性肾小球肾炎患者尿中修饰型白蛋白可能的病理生理和临床意义。【方法】46例经肾活检诊断明确,并除外狼疮性肾炎、糖尿病肾病、原发性高血压、心脑血管损害的原发性慢性肾小球肾炎患者尿标本,用免疫印记法检测尿白蛋白片断(uAF)的阳性率。【结果】病理损害I级患者uAF阳性率25%,Ⅱ级29%,Ⅲ级60%,Ⅳ级88 ...
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中西医结合护理, 2023 Diabetic nephropathy is one of the main common diseases in nephrology endocrinology. This paper reviews studies about comprehensive nursing interventions such as dietary guidance, exercise nursing, drug treatment, psychological nursing, traditional ...
TIAN Yixian (田忆贤) +6 more
doaj +1 more source
沙格列汀联合小剂量厄贝沙坦对30例早期糖尿病肾病患者预后的影响 [PDF]
, 2018 目的观察沙格列汀联合小剂量厄贝沙坦对早期糖尿病肾病患者预后的影响。方法 2017年6月—2018年3月选取该院60例早期糖尿病肾病患者为研究对象,随机分为治疗组(30例)与对照组(30例),对照组予以常规治疗+厄贝沙坦口服治疗,治疗组在对照组的基础上予以沙格列汀口服治疗,两组疗程均为3个月。检测两组患者治疗前后空腹血糖(GLU)、血清尿素氮水平、血清肌酐浓度以及瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)炎性因子水平 ...
肖国鸣
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Renal protective effect and mechanism research of hypoxia inducible factor-1α inhibitor YC-1 in diabetic nephropathy mice [PDF]
, 2023 Objective·To investigate the effect of hypoxia inducible factor-1α (HIF-1α) inhibitor YC-1 on the progression of diabetic nephropathy (DN) in mice and the potential mechanism.Methods·Ten-week-old male db/db mice (DN model) and their nondiabetic wild-type
FAN Ying +5 more
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中西医结合护理, 2022 Objective To investigate the knowledge about health education and self-management behavior in patients with early diabetic nephropathy, and provide reference for establishment of targeted health education and nursing plan.
CHEN Furong (陈芙蓉) +4 more
doaj +1 more source
Calcitriol inhibits advanced glycation end product (AGE)-elicited mesangial cell damage by sequestrated RAGE-NF-κB Signaling [PDF]
, 2015 维生素D是通过与骨，甲状旁腺，肾脏和胃肠道的相互作用调节钙稳态，已经被用来作为糖尿病肾病（DKD）的常规用药。几个临床试验表明，维生素D在糖尿病肾病的治疗中，存在着减少蛋白尿和减缓肾损伤的抗炎作用，但其作用机制尚不清楚。而晚期糖化终产物（AGEs）在血浆和肾的积累，在糖尿病肾病中，是大家公认的促炎症分子。为了探索这种抗炎作用，我们设计实验。 研究目的：探寻骨化三醇减少AGEs引起的人肾系膜细胞炎症反应的机制，具体是探寻骨化三醇对AGEs引起的人系膜细胞表达白细胞介素-6（IL-6）和单核细胞趋化因子 ...
刘波
core