Results 21 to 30 of about 794 (116)

Protein pyrrole adducts are associated with elevated glucose indices and clinical features of diabetic diffuse neuropathies 蛋白质吡咯加合物与血糖指数升高和糖尿病弥漫性神经病的临床特征相关

Journal of Diabetes, Volume 14, Issue 10, Page 646-657, October 2022., 2022
Highlights The protein pyrrole adducts in both plasma and urine correlated well with glucose indices, namely fasting blood glucose (FBG) and glycate hemoglobin A1c (HbA1c). Elevated plasma pyrrole adducts was related to positive distal symmetric polyneuropathy (DSPN) symptoms and a high resting heart rate.
Xiao Chen, Zhuyi Jiang, Lianjing Zhang, Wei Liu, Xiaohu Ren, Luling Nie, Desheng Wu, Zhiwei Guo, Weimin Liu, Xifei Yang, Yan Wu, Zhen Liang, Peter Spencer, Jianjun Liu   +13 more
wiley   +1 more source

Glomerular cell cross talk in diabetic kidney diseases 糖尿病肾病中肾小球细胞间的相互作用

Journal of Diabetes, Volume 14, Issue 8, Page 514-523, August 2022., 2022
Highlights Glomerular cell cross talk is essential for maintaining the glomerular filtration barrier. In‐depth exploration of intraglomerular signaling pathway changes during diabetic kidney disease may help discover new therapeutic targets. Abstract Diabetic kidney disease (DKD) is a severe microvascular complication of diabetes mellitus.
Ruixue Dong, Youhua Xu
wiley   +1 more source

Increased neutrophil count Is associated with the development of chronic kidney disease in patients with diabetes 中性粒细胞计数升高与2型糖尿病患者慢性肾脏病变的发展相关

Journal of Diabetes, Volume 14, Issue 7, Page 442-454, July 2022., 2022
HighlightsNeutrophil count was an independent risk factor for CKD in patients with diabetes, especially when it exceeded 3.6 × 109/L, and increased neutrophil count could predict progression of CKD in patients with diabetes. Abstract Background This study aims to investigate the potential association of peripheral inflammatory blood cell parameters ...
Rui Zhang, Jin Chen, Yanqin Xiong, Lihong Wang, Xinmei Huang, Tiange Sun, Bingbing Zha, Yueyue Wu, Cuili Yan, Shufei Zang, Qin Zhou, Zhe Huang, Jun Liu   +12 more
wiley   +1 more source

Lipid variability and risk of microvascular complications in Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial: A post hoc analysis 控制糖尿病心血管风险的行动(ACCORD)试验中的血脂变异性和微血管并发症风险:一项事后分析

Journal of Diabetes, Volume 14, Issue 6, Page 365-376, June 2022., 2022
HighlightsAssociation of lipid variability with diabetic microvascular complications. Abstract Background Greater lipid variability may cause adverse health events among diabetic patients. We aimed to examine the effect of lipid variability on the risk of diabetic microvascular outcomes among type 2 diabetes mellitus patients.
Daniel Nyarko Hukportie, Fu‐Rong Li, Rui Zhou, Jia‐Zhen Zheng, Xiao‐Xiang Wu, Meng‐Chen Zou, Xian‐Bo Wu   +6 more
wiley   +1 more source

Current gaps in management and timely referral of cardiorenal complications among people with type 2 diabetes mellitus in the Middle East and African countries: Expert recommendations 目前中东和非洲国家2型糖尿病患者在管理和及时转诊心肾并发症方面的差距:专家建议

Journal of Diabetes, Volume 14, Issue 5, Page 315-333, May 2022., 2022
Highlights This consensus document identifies challenging areas and strategic recommendations for the effective management of cardiorenal complications in type 2 diabetes mellitus in the Middle East and North Africa and Africa. There is a need for optimum glycemic control, early identification of cardiorenal complications, along with risk management ...
Alper Sonmez, Hani Sabbour, Akram Echtay, Abbas Mahdi Rahmah, Amani Matook Alhozali, Fahad Sulman al Sabaan, Fares H. Haddad, Hinde Iraqi, Ibrahim Elebrashy, Samir N. Assaad, Zaheer Bayat, Zeynep Osar Siva, Mohamed Hassanein   +12 more
wiley   +1 more source

Kidney disease parameters, metabolic goal achievement, and arterial stiffness risk in Chinese adult people with type 2 diabetes 中国成年2型糖尿病患者的肾脏疾病参数、代谢目标实现情况和动脉硬化风险

Journal of Diabetes, Volume 14, Issue 5, Page 345-355, May 2022., 2022
Highlights Provide key information on the correlation between kidney disease measures and arterial stiffness by evaluating urine albumin‐creatinine ratio and estimated glomerular filtration rate simultaneously in a large sample with type 2 diabetes. Improving management of arterial stiffness, before reaching the chronic kidney disease stage, should ...
Chen Xu, Li Li, Juan Shi, Bangqun Ji, Qidong Zheng, Yufan Wang, Tingyu Ke, Li Li, Dong Zhao, Yuancheng Dai, Fengmei Xu, Ying Peng, Yifei Zhang, Qijuan Dong, Weiqing Wang   +14 more
wiley   +1 more source

Effects of SGLT2 inhibitors on patients with diabetic kidney disease: A preliminary study on the basis of podocyturia SGLT2抑制剂对糖尿病肾病患者的影响:基于尿足细胞的初步研究

Journal of Diabetes, Volume 14, Issue 4, Page 236-246, April 2022., 2022
Highlights Diabetic kidney disease is a progressive disease with the pathology of glomerular damage and loss of podocytes. Sodium glucose cotransporter 2 inhibitors (SGLT2i) can be expected to decrease the amount of podocyte excretion. Male patients receiving SGLT2i have better diabetic kidney disease‐related parameters and podocyturia levels. Abstract
Emre Durcan, Serbay Ozkan, Halil Ibrahim Saygi, Mevlut Tamer Dincer, Ozge Polat Korkmaz, Serdar Sahin, Cebrail Karaca, Cem Sulu, Alev Bakir, Hande Mefkure Ozkaya, Sinan Trabulus, Elif Guzel, Nurhan Seyahi, Mustafa Sait Gonen   +13 more
wiley   +1 more source

C3c deposition predicts worse renal outcomes in patients with biopsy‐proven diabetic kidney disease in type 2 diabetes mellitus C3c沉积可预测2型糖尿病患者经活检证实的糖尿病肾病更差的肾脏结局

Journal of Diabetes, Volume 14, Issue 4, Page 291-297, April 2022., 2022
Highlights C3c deposition in the kidney was associated with worse renal outcomes and was an independent predictor for ESRD in DKD patients with T2DM. C3c deposition in the kidney might be a novel biomarker indicating DKD progression in T2DM. Abstract Background Although extensive efforts have been paid to identify reliable predictors for renal outcomes
Meng‐Rui Li, Zi‐Jun Sun, Dong‐Yuan Chang, Xiao‐Juan Yu, Su‐Xia Wang, Min Chen, Ming‐Hui Zhao   +6 more
wiley   +1 more source

MMC celebrating 6 years of experience and expansion 庆祝MMC六年的经验和壮大

, 2022
Journal of Diabetes, Volume 14, Issue 5, Page 356-357, May 2022.
Itamar Raz
wiley   +1 more source

Aldose reductase regulates miR-200a/miR-141 to impact TGFβ signaling and renal fibrogenesis [PDF]

, 2012
醛糖还原酶（aldosereductase，AR）是多元醇糖代谢支路的限速酶。已有很多研究证实AR在糖尿病并发症如糖尿病神经病、糖尿病视网膜病中起到重要的作用。我们前期的工作表明，AR的遗传缺失抑制了高糖引起的PKC/TGFβ的激活，进而显著减缓了C57BL/6小鼠糖尿病肾病的进程(Liuetal.，Diabetologia，2011)。然而，AR是如何调控TGFβ和肾细胞纤维化却不清楚。本研究因而在肾细胞和组织中探讨了AR对miR-200a/miR-141等表达的影响，以及miR-200a/miR ...
张晔
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