Results 71 to 80 of about 7,578 (209)
组蛋白化学修饰与12/15－脂氧化酶代谢途径在糖尿病肾病发展中的作用
Zhongshan Daxue xuebao. Yixue kexue ban, 2023 糖尿病肾病（DKD）是糖尿病患者最常见的微血管并发症之一，也是终末期肾衰竭的主要原因，其发病机制比较复杂。大量实验证实表观遗传学机制包括组蛋白化学修饰与脂质代谢产物12/15脂氧化酶（12/15-LO）参与调控DKD的特征性病理生理过程，本综述将从他们之间的相互作用关系出发，进一步探讨DKD发病机制，为DKD的治疗提供新的研究方向。
罗婧, 远航
doaj
Relationship between aldose reductase、sodium/potassium/2 chloride cotransporter type 2(NKCC2)and serum and glucocorticoid inducible protein kinase(SGK) in renal cells [PDF]
, 2008 糖尿病肾病(diabeticnephropathy,DN)是糖尿病慢性并发症(DCC)中的一种，它是糖尿病(DiabetesMellitus，DM)致死致残的主要原因。据统计，30%～40%的Ⅰ型糖尿病患者和40%的Ⅱ型糖尿病患者并发糖尿病肾病，可由最初出现蛋白尿发展到高血压、肾病综合症，最终导致肾衰和死亡，DN的3年生存率仅为50%左右。糖代谢的多元醇通路与糖尿病血管病变、肾脏病变、视网膜病变及外周神经病变等糖尿病慢性并发症密切相关。而醛糖还原酶(AldosereductaseAR ...
李劼
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Cistanche deserticola Polysaccharides Attenuates Diabetic Nephropathy in Mice by Affecting the Intestinal Flora and Inhibiting the Toll-Like Receptor 4/Nuclear Factor-κB Signaling Pathway [PDF]
The objective of this study was to investigate the ameliorative effect and potential mechanism of Cistanche deserticola polysaccharides (CDPs) on diabetic nephropathy (DN) in mice.
LUO Xinjie, YANG Jianhua, HU Junping
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[HIF-1α activation induces cholesterol homeostasis dysfunction to accelerate progression of diabetic nephropathy in rats]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Wang Y +6 more
europepmc +1 more source
, 2010 从脾与六腑的功能、"困"之"不通、虚损"及"统摄"含义等方面,将钱乙"脾主困"的思想进行扩充,认为脾指代了脾、胃、大肠、小肠、三焦、膀胱,而"脾主困"也体现了整体观 ...
荣翠平, 赵育芳
core
[Validation and comparison of diabetic retinopathy-based diagnostic models for diabetic nephropathy]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Li Y +10 more
europepmc +1 more source
Linchuang shenzangbing zazhi, 2015 糖尿病肾病（diabetic nephropathy,DN）是糖尿病患者主要的微血管并发症之一,据估计,约20%40%的糖尿病患者会发展至DN。目前,DN是引起终末期肾脏疾病的主要原因[1]。血液透析联合舒洛地特是治疗DN的一种有效、安全的治疗方法,可改善肾功能,延缓肾功能进一步恶化,提高患者的生活质量。本研究通过采用血液透析联合舒洛地特治疗DN患者取得较好的疗效。现报道如下。资料与方法一、研究对象与分组1.研究对象选择2012年9月至2014年6月在我科住院的40例经肾活检病理诊断为DN患者,
曹单单, 刘素雁
doaj
参地糖脉宁汤对实验性2型糖尿病大鼠肝细胞脂肪变的效应* [PDF]
Objective: To evaluate effects of Shendi Tang Maining Decoction on steatosis of hepatocyte in type 2 diabetes mellitus. Methods: Type 2 diabetes was induced, in female Wistar rats, by intraperitoneal injection of streptozotocin (25 mg/kg BW), fed with ...
Chen, Lei +7 more
core +2 more sources