Results 31 to 40 of about 18,889 (215)

Updated insights into the molecular pathogenesis of canine atopic dermatitis

open access: yesVeterinary Dermatology, Volume 36, Issue 4, Page 375-384, August 2025.
Abstract Atopic dermatitis (AD) is a common and chronic inflammatory skin disease with frequent relapses. The genomics revolution has greatly contributed and revolutionised our knowledge of human AD; understanding the molecular skin fingerprint of AD and associated pathogenic immune pathways has led to preclinical assessments of several novel ...
Frane Banovic
wiley   +1 more source

用低分化鼻咽癌细胞株(CNE2)为靶细胞测定鼻咽癌(NPC)患者ADCC作用

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 1986
抗体依赖的细胞介导的细胞毒(AntibodyDependent Cell-Mediated Cytotoxicity,ADCC.)是机体细胞免疫与体液免疫两大系统的协调作用,在机体的肿瘤免疫、移植免疫,某些真菌,病毒,寄生虫疾患及某些自身免疫疾患的过程中,均发挥重要作用。ADCC对那些吞噬细胞无法吞噬的体积较大的实体瘤 ...
刘庆伦
doaj  

Proteomics and Expression of Immunity Related Genes Research in Fujian Oyster Under the Stress of Iron Salt and Vibrio Parahemolyticus [PDF]

open access: yes, 2016
牡蛎隶属于软体动物门(Mollusca)、双壳纲(Bivalvia)珍珠贝目(Pterio)。牡蛎具有很高的食用价值,现已成为中国乃至世界养殖产量最大的经济贝类。然而牡蛎养殖业面临着种种威胁,其中包括了病原体的感染。 铁是脊椎动物血红蛋白的重要组成成分,对机体免疫机制也具有重要作用。但铁对无脊椎动物免疫系统的影响鲜有研究。本论文以福建牡蛎为实验物种,以牡蛎的血淋巴和鳃为实验材料,选择铁盐为胁迫方法和诸多分析技术研究铁盐对牡蛎血淋巴和鳃产生的的影响。 本文采用3mg/L的铁盐胁迫牡蛎96小时 ...
张熠玮
core  

Research on T Lymphocyte Subsets and NK Cells Activity in Peripheral Blood of Hypopharyngeal Squamous Cell Carcinoma [PDF]

open access: yes, 2017
目的:分析下咽鳞状细胞癌患者外周血T淋巴细胞亚群和NK细胞活性情况,旨在为相关研究工作提供参考资料。方法:择取2011年6月-2016年5月本院收治的95例下咽鳞状细胞癌病患为病例组,另取此期间内来本院接受健康检查的72例志愿者为正常组。使用流式细胞仪对病患开展相关检查,分析病例组与正常组的淋巴细胞亚群、NK活性情况以及不同临床分期的下咽癌病患外周血T淋巴细胞亚群以及NK细胞活性之间的关系。结果:与正常组相比,病例组的NK细胞、总B淋巴细胞、总T淋巴细胞、辅助/抑制T细胞、辅助T细胞偏低(P0.05 ...
刘存山   +7 more
core   +1 more source

Analysis of the immunomodulatory properties of mycobacterium cell wall fraction on the cytokine production of peripheral blood mononuclear cells of healthy dogs

open access: yesVeterinary Dermatology, Volume 35, Issue 6, Page 595-604, December 2024.
Background – Mycobacterium cell wall fraction (MCWF) is derived from nonpathogenic Mycobacterium phlei and is used as an immunomodulatory compound in clinical practice, yet its mode‐of‐action requires further research. Objective – To evaluate the host response to MCWF in canine peripheral blood mononuclear cells (PBMCs) by using enzyme‐linked ...
Robert Ward   +9 more
wiley   +1 more source

抗原致敏外周血树突状细胞治疗脑胶质瘤的实验研究

open access: yesZhongguo shiyan zhenduanxue, 2008
目的观察树突状细胞(DCs)从凋亡脑胶质瘤细胞获取抗原后,体外诱导抗肿瘤免疫应答及对胶质瘤细胞的特异性免疫杀伤效果。方法用粒-巨噬细胞集落刺激因子(GM-CSF)加白介素-4(IL-4)从人外周血分化、诱导DCs、γ-射线在体外诱导培养的人脑胶质瘤细胞凋亡,将DCs、T淋巴细胞和凋亡胶质瘤细胞共培养,同时设计不同类型肿瘤细胞(U937及培养胶质瘤细胞)作对照,分离、富集DCs、T淋巴细胞进行免疫应答及肿瘤细胞杀伤试验。结果与凋亡胶质瘤细胞共培养之DCs可以有效提呈胶质瘤细胞抗原,有强烈的免疫应答 ...
苗壮, 付玉, 薄丽娟, 高正
doaj  

Effects of Ciji Hua’ai Baosheng Decoction on Hematopoiesis & Tumor Cells Apoptosis Related Factors of Tumor-bearing Chenmotherapy Mice with H22 Hepatoma Carcinoma Cells [PDF]

open access: yes, 2015
目的:研究并证实慈济化癌保生汤(CijiHua’aiBaoshengDecoction,CHBD)对肝癌化疗后机体整体机能的改善作用,明确慈济化癌保生汤对肝癌化疗后机体血细胞的保护作用、造血相关因子的生成作用、促肿瘤细胞凋亡作用,为慈济化癌保生汤在临床的应用提供科学依据。 研究方法:培养昆明(KM)小鼠肝癌H22细胞,稀释为2×107/ml,接种于60只小鼠右前腋下,常规饲养7天后,全部形成皮下移植瘤,以环磷酰胺(CyclophosphamideTabletsandInjections,CTX ...
程尧
core  

Development of a Pt(II) compound based on indocyanine green@human serum albumin nanoparticles: integrating phototherapy, chemotherapy and immunotherapy to overcome tumor cisplatin resistance

open access: yesRare Metals, Volume 43, Issue 11, Page 6006-6022, November 2024.
Graphical abstract AbstractCisplatin resistance is the main cause for the failure of cancer therapy. To solve the problem, we proposed to develop a novel human serum albumin (HSA) nanoplatform to integrate chemotherapy, photothermal therapy (PTT) and immunotherapy.
Xue‐Yu Man   +7 more
wiley   +1 more source

乙肝疫苗免疫前后淋巴细胞表型研究

open access: yesZhongguo shiyan zhenduanxue, 2001
目的 了解乙肝疫苗(HBsAg)免疫后健康成人外周血T淋巴细胞的表型变化,分析表型变化和是否产生抗体应答或弱应答的关系。方法 应用间接免疫荧光法原理和FACScan流式细胞仪分析了免疫后健康成人外周血T淋巴细胞的表型变化;同时应用ELISA原理,检测了免疫后HBV相关抗体。结果和结论 免疫后CD3+细胞和CD4+细胞活化增生,提高了机体的免疫调节能力;同时测定了HBsAb的阳性率。
李菁华   +3 more
doaj  

半枝莲化学成分的研究 [PDF]

open access: yes, 2005
目的:半枝莲化学成分的研究。方法:利用硅胶柱层析,通过波谱分析鉴定其化学结构。结果:分离并鉴定了5个化合物:β谷甾醇(βsitosterol,Ⅰ)、对甲氧基桂皮酸(pmethoxycinnamicacid,Ⅱ)、β胡萝卜苷(βdaucosterol,Ⅲ)、scutellaricacid(Ⅳ)和scutebarbatineA(Ⅴ)。结论:化合物Ⅳ和Ⅴ结构较特别,含量较高 ...
吴凤锷, 陶曙红
core  

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