Results 11 to 20 of about 18,889 (215)
Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 4, Page 455-460, April 2026.ABSTRACT Objective To estimate the residual risk of maternal–fetal transmission after primary cytomegalovirus (CMV) infection in the periconceptional period or the first trimester in women treated with valacyclovir, and to assess whether the presence of glycoprotein B2 (gB2)‐specific immunoglobulin (Ig)‐G antibodies on immunoblot analysis refines fetal
K. O. Kagan +6 more
wiley +1 more source
Studies of Imagings in Lung Cancer and Inflammation by 99mTc Labled New Ligand（CB86）of TSPO [PDF]
, 2016 摘要 研究背景和目的 肿瘤曾经被定义为一种和心血管病、糖尿病或者慢性呼吸系统疾病等相似的非传染性疾病。尽管它们被认为是随着患者年龄的增大、都市化的不断发展以及不健康的生活习惯而逐渐出现的，人们也慢慢认识到炎症也是导致癌症发病的重要环节之一。很多研究已经证实，炎症是一个明确可以导致肿瘤的危险因子，即伴随着人体内炎症因子的增加，C反应蛋白水平的升高，肿瘤的危险因素也在增高。炎症的环境可能是导致各种癌症发生的重要原因。如慢性乙肝及丙肝，或肝吸虫病等可增加肝癌风险；又例如空气中的刺激性物质，如石棉，PM2.5等，
刘鹏
core
Veterinary Dermatology, Volume 37, Issue 2, Page 306-318, April 2026.Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova +6 more
wiley +1 more source
The Th cell subsets analysis of syphilis patients and mechanism of Treponema pallidum infection [PDF]
, 2016 梅毒是由梅毒螺旋体引起的性传播疾病。梅毒螺旋体可侵入人体各个组织器官，引起各种临床表现。目前机体对梅毒螺旋体的免疫机制尚不清楚。本课题分别从体内和体外实验分析梅毒螺旋体引起的初始Th细胞分化，初步探讨梅毒螺旋体细胞免疫机制。我们分析32例梅毒患者外周血辅助性T细胞（Th）亚群含量变化；通过兔皮内接种模型，分析梅毒螺旋体感染后局部炎症反应中IFN-γ和IL-4mRNA的表达随时间变化情况。体内研究发现梅毒螺旋体感染后细胞免疫应答在人外周血和兔皮损中IFN-γ含量明显升高，Th1型细胞增多 ...
张巧
core
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Skin wound injuries are often accompanied by bacterial infections and severe inflammation. Especially, M1‐type macrophages at the wound site can trigger a cascade of inflammatory responses, mediating a vicious cycle of inflammation. Meanwhile, hypoxia further exacerbates vascular damage and constriction in the wound microenvironment, thereby ...
Xianfeng Wang +6 more
wiley +1 more source
Mechanistic Analysis of Immunomodulation by Human Induced Pluripotent Stem Cells Derived Mesenchymal Stem Cells in Mice [PDF]
, 2015 背景：间充质干细胞是具有自我更新能力和分化能力的组织细胞前体细胞，能够分化为一系列的间质细胞，包括成骨细胞、成软骨细胞、脂肪细胞、肌细胞和内皮细胞等。细胞治疗是再生医学发展的一个重要分支。越来越多的研究发现，间充质干细胞能够修复组织损伤，达到一定治疗效果。因此，间充质干细胞被视为天然组织工程材料的重要种子细胞，具有广阔的应用前景。此外，间充质干细胞具有负性免疫调节能力。在体外共培养条件下，间充质干细胞能够抑制免疫细胞功能，包括抑制T细胞反应，抑制树突状细胞的成熟和抗原提成，抑制B细胞激活和增殖 ...
李成林
core
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu +5 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2013 肺癌是严重威胁人类生命健康的常见恶性肿瘤,它的发生、进展和转移等与机体的细胞免疫机能密切相关。细胞免疫是机体抗肿瘤免疫的重要机制,细胞免疫应答主要是T细胞介导的特异性细胞免疫[1]。T淋巴细胞是机体免疫系统内功能最重要的一大细胞群,同时又是一个复杂的细胞群体。T细胞和NK细胞在免疫监视、杀伤靶细胞及免疫调节方面具有极其重要的作用。正常情况下,T细胞及亚群的数目处于相对平衡状态,免疫功能稳定。若T细胞总数或者CD4+/CD8 ...
任林广 +4 more
doaj
Preparation and Characterization of Semaphorin3Fc Monoclonal Antibody and the Preliminary Application [PDF]
, 2015 研究背景和目的 抑癌基因发生异常是癌症发生的机制之一。人类基因的很多区域发生改变时可导致细胞失控性生长。Sema3F作为肺癌19个候选抑癌基因之一，是Ⅲ型Semaphorin（即神经导向因子，最初作为Neuropilins的配体在神经系统中发挥排斥神经节轴突和调节神经系统发育的作用）家族的一个成员。目前有研究发现，与正常组织相比Sema3F蛋白在肿瘤细胞中的表达普遍存在下调的趋势，并在血管形成以及肿瘤增殖、凋亡、粘附和转移等中起着负向调节作用。此外，诸多体内或者体外实验已经证明 ...
李哲
core
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang +7 more
wiley +1 more source