Results 111 to 120 of about 14,469 (162)

Exploiting targeted degradation of cyclins and cyclin-dependent kinases for cancer therapeutics: a review. [PDF]

open access: yesJ Zhejiang Univ Sci B
Zheng S   +8 more
europepmc   +1 more source

Heat stress affects expression levels of circadian clock gene Bmal1 and cyclins in rat thoracic aortic endothelial cells. [PDF]

open access: yesNan Fang Yi Ke Da Xue Xue Bao
Chang X   +7 more
europepmc   +1 more source

锌指蛋白ZNF23在非小细胞肺癌中表达的研究

open access: yesZhongguo shiyan zhenduanxue
目的 探讨ZNF23非小细胞肺癌中的表达、对肺癌生物学行为的影响及相关作用机制。方法 免疫组化检测非小细胞肺癌组织中ZNF23表达,Western Blot及realtime PCR方法检测ZNF23在癌与癌旁组织中蛋白及mRNA表达,siRNA转染及细胞周期实验检测ZNF23在调节细胞周期进展中发挥的作用。结果 与癌旁正常组织相比,ZNF23在非小细胞肺癌临床石蜡切片中表达降低,并与组织类型、分化程度、TNM分期、淋巴结转移相关;Western Blot及realtime ...
曲微   +4 more
doaj  

[Expression and its clinical significance of cell-cycle dependent kinase 1 in malignant peripheral nerve sheath tumors]. [PDF]

open access: yesZhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Liu Y   +7 more
europepmc   +1 more source

PGC-1α诱导细胞周期阻滞抑制肾透明细胞癌的实验研究

open access: yesZhongguo shiyan zhenduanxue
目的 探讨过氧化物酶体增殖物激活受体γ共激活剂1 α(PGC-1α)在透明细胞型肾细胞癌(ccRCC)中的调控作用。方法 本研究收集在郑州大学附属第一医院治疗的98例ccRCC患者的肾癌和癌旁组织,以及患者一般临床资料。利用RT-qPCR法检测不同临床分期和病理分级ccRCC患者组织中PGC1α mRNA的相对表达水平。使用细胞培养模型786-O、ACHN、RCC4等ccRCC细胞系以及人肾皮质近曲小管上皮永生化细胞系(HK-2)探讨PGC-1α在肿瘤细胞中的作用。采用CCK8实验、细胞克隆形成实验 ...
南永浩   +4 more
doaj  

[PCID2 is highly expressed in gastric cancer and affects the prognosis by regulating cancer cell cycle and proliferation]. [PDF]

open access: yesNan Fang Yi Ke Da Xue Xue Bao
Zhang N   +7 more
europepmc   +1 more source

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