Zhongguo shiyan zhenduanxue, 2007 目的探讨中草药檞皮素抑制人肝癌细胞株SMMC-7721的增殖作用。方法运用MTT法检测檞皮素对SMMC-7721细胞增殖的抑制作用,流式细胞仪技术分析檞皮素对SMMC-7721细胞增殖周期的影响。结果10-320μmol/L浓度的檞皮素均能抑制SMMC-7721细胞的生长,且呈明显的时间,剂量依赖性关系,细胞周期分析显示檞皮素组G1期细胞比例明显增多,呈量效关系。结论檞皮素抑制SMMC-7721细胞增殖,可能通过使SMMC-7721细胞停滞在G1期而诱导其凋亡。
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Exploiting targeted degradation of cyclins and cyclin-dependent kinases for cancer therapeutics: a review. [PDF]
J Zhejiang Univ Sci BZheng S +8 more
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Endomitosis: a new cell fate in the cell cycle leading to polyploidy in megakaryocytes and hepatocytes. [PDF]
J Zhejiang Univ Sci BHua QH, Zhang X, Tian R, She Z, Huang Z.
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Heat stress affects expression levels of circadian clock gene Bmal1 and cyclins in rat thoracic aortic endothelial cells. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoChang X +7 more
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[Relationship between GTSE1 and Cell Cycle and Potential Regulatory Mechanisms in Lung Cancer Cells]. [PDF]
Zhongguo Fei Ai Za ZhiWang C +5 more
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[Licochalcone A induces cell cycle arrest in human lung squamous carcinoma cells via the PI3K/Akt signaling pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Fan X, Wang J, Wang L.
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Zhongguo shiyan zhenduanxue目的 探讨ZNF23非小细胞肺癌中的表达、对肺癌生物学行为的影响及相关作用机制。方法 免疫组化检测非小细胞肺癌组织中ZNF23表达，Western Blot及realtime PCR方法检测ZNF23在癌与癌旁组织中蛋白及mRNA表达，siRNA转染及细胞周期实验检测ZNF23在调节细胞周期进展中发挥的作用。结果 与癌旁正常组织相比，ZNF23在非小细胞肺癌临床石蜡切片中表达降低，并与组织类型、分化程度、TNM分期、淋巴结转移相关；Western Blot及realtime ...
曲微 +4 more
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[Expression and its clinical significance of cell-cycle dependent kinase 1 in malignant peripheral nerve sheath tumors]. [PDF]
Zhongguo Xiu Fu Chong Jian Wai Ke Za ZhiLiu Y +7 more
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[Effects of polyphyllin Ⅶ on proliferation, apoptosis and cell cycle of diffuse large B-cell lymphoma cells]. [PDF]
Zhonghua Xue Ye Xue Za ZhiSun YQ, Fu Y, Ji OX, Wang LJ.
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Zhongguo shiyan zhenduanxue目的 探讨过氧化物酶体增殖物激活受体γ共激活剂1 α(PGC-1α)在透明细胞型肾细胞癌(ccRCC)中的调控作用。方法 本研究收集在郑州大学附属第一医院治疗的98例ccRCC患者的肾癌和癌旁组织，以及患者一般临床资料。利用RT-qPCR法检测不同临床分期和病理分级ccRCC患者组织中PGC1α mRNA的相对表达水平。使用细胞培养模型786-O、ACHN、RCC4等ccRCC细胞系以及人肾皮质近曲小管上皮永生化细胞系(HK-2)探讨PGC-1α在肿瘤细胞中的作用。采用CCK8实验、细胞克隆形成实验 ...
南永浩 +4 more
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