Results 31 to 40 of about 17,361 (166)
Updated insights into the molecular pathogenesis of canine atopic dermatitis
Veterinary Dermatology, Volume 36, Issue 4, Page 375-384, August 2025.Abstract Atopic dermatitis (AD) is a common and chronic inflammatory skin disease with frequent relapses. The genomics revolution has greatly contributed and revolutionised our knowledge of human AD; understanding the molecular skin fingerprint of AD and associated pathogenic immune pathways has led to preclinical assessments of several novel ...
Frane Banovic
wiley +1 more source
The Role of SRC-1 in myocardial infarction [PDF]
, 2016 类固醇激素受体辅激活子（steroidreceptorcoactivator，SRC）作为一类转录协同因子，能够与多种转录因子相互作用并增强其转录活性。SRC-1是SRC家族（SRC-1/NCoA-1、SRC-2/GRIP/TIF2、SRC-3/AIB1/ACTR/pCTP/RAC3/TRAM-1）的一员。已有的研究表明SRC-1在体内具有多种生物学功能，SRC-1可参与乳腺癌、前列腺癌、肝癌等多种癌症的增殖与入侵。SRC-1在脑内突触的可塑性、神经干细胞分化等生理过程具有重要调控作用。此外，SRC ...
占少鹏
core
Systematic Entomology, Volume 50, Issue 3, Page 495-518, July 2025.Using genomic data from 285 species across 19 planthopper families, we conducted the first phylogenomic study targeting global planthoppers and inferred their phylogeny with the highest resolution so far. We proposed taxonomic changes including the establishment of a new family Borysthenidae stat. rev. and a new superfamily Meenoploidea superfam.
Junchen Deng +9 more
wiley +1 more source
Study of differential cytokine IFN-γ,IL-10，TGF-β and IL-17 level in patients with myasthenia gravis with antibodies against AChR ,MuSK and LRP4 [PDF]
, 2016 目的:通过采用酶联免疫吸附(ELISA)法检测重症肌无力(myastheniagravis，MG)患者血清乙酰胆碱受体抗体(AChR-Ab)，肌肉特异性酪氨酸激酶抗体(MuSK-Ab)，低密度脂蛋白受体相关蛋白4抗体（LRP4-Ab）浓度，探讨AChR-Ab，MuSK-Ab，LRP4-Ab与重症肌无力临床分型、及与细胞因子干扰素-γ(IFN-γ)，白细胞介素-10（IL-10），生长转化因子-β（TGF-β），白细胞介素-17（IL-17）的关系。 方法： 1.本研究分为重症肌无力组和健康对照组 ...
李若冰
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Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 6, Page 749-760, June 2025.ABSTRACT Objective Placental dysfunction can result in small‐for‐gestational age (SGA) or fetal growth restriction (FGR). The aim of this prospective cohort study was to assess the association of the cerebroplacental ratio (CPR) and other more conventional fetoplacental Doppler indices, circulating placental growth factor (PlGF) levels and soluble fms ...
J. Hong +6 more
wiley +1 more source
pJAK2 polypeptide,an antagonist of suppressors of cytokine signaling-1,can enhance the antitumor effect of dendritic cells [PDF]
, 2013 目的:探讨细胞因子信号转导抑制因子-1(SuPPrESSOrS Of CyTOkInE SIgnAlIng1,SOCS1)拮抗物PJAk2多肽(氨基酸序列号为1001-1013)参与树突状细胞(dEndrITIC CEllS,dCS)的体外诱导培养后对dCS抗肿瘤作用的影响。方法:采集健康人外周血,离心获得单个核细胞,用重组人粒细胞巨噬细胞集落刺激因子(rECOMbInAnT HuMAn grAnulOCyTE-MACrOPHAgE COlOny STIMulATIng fACTOr,rHgM-CSf ...
丁园 +8 more
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Veterinary Dermatology, Volume 36, Issue 3, Page 291-301, June 2025.Background – Canine interdigital furunculosis (CIF) is a complex, relapsing inflammatory condition, typically complicated by deep bacterial infections requiring prolonged systemic antibiotics. Hypothesis/Objectives – This split‐body study, where dogs acted as their own control, evaluated whether the adjunctive use of fluorescent light energy (FLE ...
A. Lange +12 more
wiley +1 more source
Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 2, Page 226-234, February 2025.ABSTRACT Objectives Ultrasound is the first‐line imaging modality of the pelvis in the pediatric and adolescent gynecology (PAG) population. Ultrasound findings in pre‐ and postpubertal PAG patients differ from those in adults. Diagnostic models for adnexal pathology have not been validated in this cohort.
N. Cooper +15 more
wiley +1 more source
Effects of Treponema pallidum on THP-1 derived macrophage polarization [PDF]
, 2015 梅毒螺旋体（Treponemapallidum）是性传播疾病梅毒的致病菌，尽管有关T.pallidum的研究已经开展近一个多世纪，对其生物学及病原学特性有了一定的了解，然而对于T.pallidum致病机制的认识还处于起步阶段。巨噬细胞作为机体防御外来病原体的第一道防线，在对T.pallidum的识别、吞噬、抗原提呈、杀伤等方面均发挥着重要作用。随着对巨噬细胞研究不断深入，有学者将巨噬细胞分为两种不同的极化类型，即促进炎症发展的M1型巨噬细胞和在抑制炎症反应及组织修复等方面发挥作用的M2型巨噬细胞 ...
席亚
core
Veterinary Dermatology, Volume 35, Issue 6, Page 595-604, December 2024.Background – Mycobacterium cell wall fraction (MCWF) is derived from nonpathogenic Mycobacterium phlei and is used as an immunomodulatory compound in clinical practice, yet its mode‐of‐action requires further research. Objective – To evaluate the host response to MCWF in canine peripheral blood mononuclear cells (PBMCs) by using enzyme‐linked ...
Robert Ward +9 more
wiley +1 more source