细胞粘附肽（RGDS）抑制人胃癌细胞BGC823生长及诱导其凋亡
Zhongguo shiyan zhenduanxue, 2008 目的研究细胞粘附肽（RGDS）对人胃癌细胞系BGC823（Human stomach cancer BGC823）生长增殖的影响,进而探讨RGDS诱导BGC823细胞凋亡的作用。方法用不同浓度的RGDS处理BGC823细胞48h后,MTT法检测RGDS对BGC823细胞生长增殖的抑制作用,通过HE染色、透射电子显微镜、免疫组织化学、流式细胞术和凋亡细胞的DNA片断等方法观察凋亡细胞的形态结构变化以及定性、定量检测细胞凋亡。结果RGDS能抑制BGC823细胞的生长增殖,并呈浓度依赖性 ...
刘强 +4 more
doaj
[Smeglutide inhibits high glucose-induced proliferation of myocardial fibroblasts by downregulating TGFβ/Smad3 signaling]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Li J +6 more
europepmc +1 more source
PRL-3调节PI3K信号通路在促进结肠癌细胞增殖侵袭中的作用
Zhongshan Daxue xuebao. Yixue kexue ban, 2013 【目的】 研究肝再生磷酸酶-3 (PRL-3)的过表达与PI3K信号通路的调节及其与结肠癌细胞增殖侵袭的关系?【方法】 构建稳定转染PRL-3基因和空白对照质粒的结肠癌细胞株LoVo- PRL-3和LoVo-VC,用qRT-PCR和Western blot的方法对miR-21及其靶蛋白PTEN的表达进行检测,在稳转细胞株中转染miR-21或对其进行敲除,用CCK-8?Tanswell实验对细胞的增殖侵袭能力的变化进行研究?【结果】 LoVo- PRL-3细胞的增殖侵袭能力要强于对照组LoVo-VC细胞 ...
doaj
Bcl-2抑制剂ABT737增加GSK3抑制剂SB216763引起的A549细胞凋亡
Zhongguo shiyan zhenduanxue, 2016 目的探讨SB216763联合ABT737对肺癌细胞增殖和凋亡的作用及其机制。方法MTT法检测SB216763或联合ABT737对A549细胞增殖的影响。流式细胞术检测SB216763或联合ABT737对A549细胞凋亡的影响。Western blot检测各组内的cleaved caspase3和cytochrome C蛋白表达水平。结果 SB216763抑制了A549细胞的增殖,且呈现剂量依赖性。ABT737增强了SB216763对A549细胞的抑制作用 ...
石少敏, 王静, 于杜娟, 赵永娟
doaj
[GPR109A partly mediates inhibitory effects of β-hydroxybutyric acid on lung adenocarcinoma cell proliferation, migration and invasion]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Huang Y +5 more
europepmc +1 more source
[Effects of miR-100-5p on proliferation and apoptosis of acute myeloid leukemia cells and the underlying molecular mechanism]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiFan XR, Yang Y, Sun Y, DU CM.
europepmc +1 more source
[Effect of polydatin on the proliferation and apoptosis of THP-1 cells and the mechanism]. [PDF]
Zhongguo Dang Dai Er Ke Za Zhi, 2022 Wang CM, Qi WJ, Ren YJ, Sheng GY.
europepmc +1 more source
Combretastatin A4 Phosphate对人晶状体上皮细胞
Zhongshan Daxue xuebao. Yixue kexue ban, 2012 ［目的］ 研究Combretastatin A4 Phosphate（CA4P）对晶状体上皮细胞系SRA01/04增殖及迁移影响,初步探讨其抑制细胞增殖的机制。［方法］ 以晶状体上皮细胞系SRA01/04为实验对象，设空白对照组及CA4P组，分别以PBS或1 μmol/L CA4P处理15 min，于0、24、48、72 h后进行检测。通过WST-1法检测细胞增殖能力；划痕试验细胞迁移能力；Annex in V-FITC /PI双染法检测细胞死亡方式；PI染色法细胞周期；免疫荧光法检测细胞骨架蛋白（α ...
doaj
[Progress in diagnosis and treatment of RAS-related autoimmune lymphoproliferative disorder]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiRen JN, Wan Y, Zhu XF.
europepmc +1 more source
[Lactate-induced up-regulation of PLEKHA4 promotes proliferation and apoptosis of human glioma cells]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Ye J, Xu W, Xi B, Wang N, Chen T.
europepmc +1 more source