Results 1 to 10 of about 15,306 (119)

Protective effects of nattokinase against microvasculopathy and neuroinflammation in diabetic retinopathy 纳豆激酶对糖尿病视网膜病变微血管病变和神经炎症的保护作用

Journal of Diabetes, Volume 15, Issue 10, Page 866-880, October 2023., 2023
Highlights Nattokinase rescued endothelial dysfunction and pericyte loss in the diabetic retina. Nattokinase attenuated diabetes‐induced retinal inflammation and neurodegeneration. High mobility group box 1 signaling was involved in nattokinase‐mediated retinal protection.
Zijing Huang, Wai Kit Chu, Tsz Kin Ng, Shaolang Chen, Jiajian Liang, Chong‐Bo Chen, Yanxuan Xu, Biyao Xie, Shuping Ke, Qingping Liu, Weiqi Chen, Dingguo Huang   +11 more
wiley   +1 more source

Evaluating the role of time in range as a glycemic target during short‐term intensive insulin therapy in patients with newly diagnosed type 2 diabetes 在新诊断的2型糖尿病患者中评估短期胰岛素强化治疗期间血糖达标时间作为血糖目标的作用

Journal of Diabetes, Volume 15, Issue 2, Page 133-144, February 2023., 2023
Highlights Whether time in range (TIR) during short‐term intensive insulin therapy (SIIT) was associated with treatment response to the therapy in patients with newly diagnosed type 2 diabetes was uncertain. TIRPIR, which was calculated according to the percentage of glucose points within predefined glycemic targets, was superior to TIR3.9–7.8mmol/L ...
Liehua Liu, Weijian Ke, Lijuan Xu, Hai Li, Juan Liu, Xuesi Wan, Jianbin Liu, Wanping Deng, Xiaopei Cao, Haipeng Xiao, Yanbing Li   +10 more
wiley   +1 more source

The effect of short‐term intensive insulin therapy on inflammatory cytokines in patients with newly diagnosed type 2 diabetes 短期胰岛素强化治疗对新诊断的2型糖尿病患者炎性细胞因子的影响

Journal of Diabetes, Volume 14, Issue 3, Page 192-204, March 2022., 2022
Highlights Many proinflammatory cytokines could be decreased after 1 week of intensive insulin therapy using continuous subcutaneous insulin infusion (CSII). This was the first report showing that the cytokines of interleukin‐6 receptor (IL‐6R), tissue inhibitor of metalloproteinase‐2 (TIMP‐2), platelet‐derived growth factor type BB (PDGF‐BB), and ...
Junyu He, Peiji Dai, Liyi Liu, Yanqing Yang, Xibo Liu, Yanbing Li, Zhihong Liao   +6 more
wiley   +1 more source

A masked, randomised clinical trial evaluating the efficacy and safety of lokivetmab compared to saline control in client‐owned dogs with allergic dermatitis

Veterinary Dermatology, Volume 32, Issue 5, Page 477-e131, October 2021., 2021
Background – Interleukin (IL)‐31 is an important mediator in canine atopic dermatitis (cAD) and also may be dysregulated in other allergic diseases. Hypothesis/Objectives – To demonstrate the efficacy and safety of lokivetmab (canine anti‐IL‐31 monoclonal antibody) for treatment of pruritus associated with allergic dermatitis in dogs.
Leen Van Brussel, Hilde Moyaert, Monica Escalada, Sean P. Mahabir, Michael R. Stegemann   +4 more
wiley   +1 more source

败酱草总皂苷含药血清对人胃癌SGC-7901细胞增殖的影响及机制研究

Zhongguo shiyan zhenduanxue, 2022
目的 探讨败酱草总皂苷含药血清对人胃癌SGC-7901细胞增殖和细胞周期的影响。方法 取购自中国科学院典型培养物保藏委员会细胞库的人胃癌SGC-7901细胞株进行培养，分为对照组和药物组，对照组加入含10%澳洲胎牛血清的RPMI1640培养液，药物组按加入败酱草总皂甙含药血清浓度分为低浓度组、中浓度组和高浓度组，采用CCK8法检测各组细胞活力，采用流式细胞术检测各组细胞周期，采用Western blot技术检测各组细胞周期相关蛋白[细胞周期蛋白D1（CyclinD1）、细胞周期蛋白E（CyclinE ...
叶艺兰, 王志红, 刘建祥, 王剑梅   +3 more
doaj  

Treatment and outcome of 370 cases with spontaneous or post‐laser twin anemia–polycythemia sequence managed in 17 fetal therapy centers

Ultrasound in Obstetrics &Gynecology, Volume 56, Issue 3, Page 378-387, September 2020., 2020
ABSTRACT Objective To investigate the antenatal management and outcome in a large international cohort of monochorionic twin pregnancies with spontaneous or post‐laser twin anemia–polycythemia sequence (TAPS). Methods This study analyzed data of monochorionic twin pregnancies diagnosed antenatally with spontaneous or post‐laser TAPS in 17 fetal therapy
L. S. A. Tollenaar, F. Slaghekke, L. Lewi, Y. Ville, M. Lanna, A. Weingertner, G. Ryan, S. Arévalo, A. Khalil, C. O. Brock, P. Klaritsch, K. Hecher, G. Gardener, E. Bevilacqua, K. V. Kostyukov, M. O. Bahtiyar, M. D. Kilby, E. Tiblad, D. Oepkes, E. Lopriore, Collaborators, J. M. Middeldorp, M. C. Haak, F. J. C. M. Klumper, J. Akkermans, H. Delagrange , V. Pandya, S. Faiola, R. Favre, S. R. Hobson, C. Rodo, B. Thilaganathan, R. Papanna, P. Greimel, M. Tavares de Sousa, A. Carlin, K. A. Gladkova, J. A. Copel   +37 more
wiley   +1 more source

G protein‐coupled receptor kinase‐2: A potential biomarker for early diabetic cardiomyopathy G蛋白偶联受体激酶2:早期糖尿病心肌病的潜在生物标记物

Journal of Diabetes, Volume 12, Issue 3, Page 247-258, March 2020., 2020
Highlights The GRK2 level elevated not only in the myocardium of diabetic mice with early stage of diabetic cardiomyopathy but also in the peripheral blood mononuclear cells of type 2 diabetic patients with the early stage of diabetic cardiomyopathy. The study findings suggested that the GRK2 was a potential biomarker for early diabetic cardiomyopathy.
Shuiqing Lai, Xiaoying Fu, Shufen Yang, Shuting Zhang, Qiuxiong Lin, Mengzhen Zhang, Hongmei Chen   +6 more
wiley   +1 more source

Titanium Implant Abutments With Polydopamine‐Mesoporous Cerium Dioxide Coatings for Enhanced Antibacterial, Anti‐Inflammatory, and Soft Tissue Integration Properties

Rare Metals, Volume 45, Issue 6, June 2026.
ABSTRACT The poor soft tissue integration around titanium implants creates a microgap that serves as a pathway for pathogen invasion, resulting in infection, inflammation, and the progression of peri‐implantitis. As the implant’s transmucosal component, the abutment determines the degree of peri‐implant soft tissue attachment.
Xuan Li, Min Xing, Haoyue Liu, Kuicai Ye, Xuanyong Liu, Li Ma, Wenhao Qian, Jiajun Qiu   +7 more
wiley   +1 more source

Predictive value of gB2 antibodies for maternal–fetal transmission after primary cytomegalovirus infection treated with valacyclovir

Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 4, Page 455-460, April 2026.
ABSTRACT Objective To estimate the residual risk of maternal–fetal transmission after primary cytomegalovirus (CMV) infection in the periconceptional period or the first trimester in women treated with valacyclovir, and to assess whether the presence of glycoprotein B2 (gB2)‐specific immunoglobulin (Ig)‐G antibodies on immunoblot analysis refines fetal
K. O. Kagan, A. L. Bissinger, O. Roth, J. Sonek, M. Hoopmann, Y. Ville, M. Enders   +6 more
wiley   +1 more source

Efficacy of Der f 2/Zen 1‐LAMP1 Plasmid‐Based Vaccine Immunotherapy in Dogs With Atopic Dermatitis: A Proof‐of‐Concept Study

Veterinary Dermatology, Volume 37, Issue 2, Page 306-318, April 2026.
Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova, Chigusa Matsumoto, Shoji Ogino, Toshihiro Tsukui, Kim Love, Marcy Murphy, Ina Herrmann   +6 more
wiley   +1 more source