Results 21 to 30 of about 16,510 (164)

Ultrasound features in early pregnancy for predicting abnormal karyotype in first‐trimester miscarriage

Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 3, Page 376-384, March 2026.
ABSTRACT Objective To investigate whether combining abnormal morphological features observed on ultrasound in live pregnancies that ended in a first‐trimester miscarriage can predict an abnormal karyotype. Methods This retrospective observational cohort study was conducted at the early‐pregnancy assessment unit at University College London Hospital ...
T. Setty, S. L. Kastora, T. Tellum, J. Farren, E. Jauniaux, D. Jurkovic   +5 more
wiley   +1 more source

Evaluation of Nonel N-(piperidin-4-yl)benzamide Derivatives as Potential Cell Cycle Inhibitors in HepG2 cells [PDF]

, 2015
肝癌是目前世界上引起致高死亡率的疾病之一。细胞周期紊乱是引起肿瘤细胞增殖失控的主要原因，越来越多的学者致力于研究细胞周期抑制剂。索拉非尼作为一个多靶点广谱抗肿瘤药，近几年来基于其结构改造的化合物层出不穷。因此，本文以索拉非尼为先导化合物，保留其二芳醚结构，将脲基改造成酰胺键，并插入一个亲水基团，设计合成了一系列的索拉非尼类似物——N-(4-哌啶基)-苯甲酰胺类化合物，共合成了45个终产物，合成方法简单易操作，产物易纯化，且收率高。通过初步生物学活性的筛选 ...
侯瑾
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Performance of non‐invasive prenatal testing in vanishing‐twin and multiple pregnancies: results of TRIDENT‐2 study

Ultrasound in Obstetrics &Gynecology, Volume 66, Issue 6, Page 738-746, December 2025.
ABSTRACT Objective To evaluate the performance of non‐invasive prenatal testing (NIPT) in vanishing‐twin and multiple pregnancies. Methods This study was conducted as part of the TRIDENT‐2 study, in which NIPT was offered as a first‐tier screening test to women with a multiple pregnancy or vanishing‐twin pregnancy between 1 June 2020 and 31 March 2023 ...
J. C. A. van Eekhout, C. J. Bax, L. van Prooyen Schuurman, E. C. Becking, A. J. E. M. van der Ven, D. Van Opstal, E. M. J. Boon, M. V. E. Macville, M. N. Bekker, R. J. H. Galjaard, on behalf of the Dutch NIPT Consortium, E.A. Sistermans, L. Henneman, A. Polstra, E. Voorhoeve, S.L. Zelderen‐Bhola, E.M.J. Boon, M.P.R. Lombardi, M.C. Bakker, E.J. Bradley, E.M.J. Boon, C. Louwerens‐Zintel, M. Smit, M.C. van Maarle, M.B. Tan‐Sindhunata, K. van der Meij, H. Meij, C.J. Bax, E. Pajkrt, I.H. Linskens, L. Martin, J.T. Gitsels‐van der Wal, R. J. H. Galjaard, D. van Opstal, M.I. Srebniak, F.M. Sarquis Jehee, I.H.I.M. Hollink, F. Sleutels, W. de Valk, W.H. Deelen, A.M.S. Joosten, K.E.M. Diderich, M.E. Redeker, A.T.J.I. Go, M.F.C.M. Knapen, S. Galjaard, A.K.E. Prinsen, A.P.G. Braat, M.J.V. Hoffer, N.S. den Hollander, E.J.T. Verweij, M.C. Haak, M.V.E. Macville, S.J.C. Stevens, A. van der Wijngaard, L.H. Houben, M.A.A. van Esch‐Lennarts, L. Hamers, A.G.P. Jetten, S.A.I. Ghesquiere, B. de Koning, M. Zamani Esteki, C.J. Heesterbeek, C.E.M. de Die‐Smulders, H. Brunner, M.J. Pieters, A.B.C. Coumans, D.F.C.M. Smeets, B.H.W. Faas, D. Westra, M.M. Weiss, I. Derks‐Prinsen, I. Feenstra, M. van Rij, E. Sikkel, R.F. Suijkerbuijk, B. Sikkema‐Raddatz, I.M. van Langen, K. Bouman, L.K. Duin, G.H. Schuring‐Blom, K.D. Lichtenbelt, M.N. Bekker, E. van Vliet‐Lachotzki, J. Pot, A. J. E. M. van der Ven, S van 't Padje   +86 more
wiley   +1 more source

the mechanism investigation of neuronal specific protein CEND1on cell proliferation [PDF]

, 2015
阿尔茨海默病(Alzheimer’sdisease,AD)是一种神经退行性疾病，临床表现 为渐进性的记忆力丧失以及认知障碍。大量研究阐述了AD的病理特征和微观机 制，但目前为止尚未找到有效的治疗途径，因此继续深入研究AD致病过程，对 于疾病的预防和治疗具有重要意义。研究证实，区别于正常神经元终末分化和停 止分裂的生理状态，AD病人大脑中的神经元细胞周期会发生紊乱，部分神经元 能够重新进入细胞周期。这些神经元的细胞周期被重新激活后，进入细胞凋亡途 径CRND ...
牛雅琼
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Is parvovirus B19 infection upsurge in 2023–2024 associated with adverse pregnancy outcome?

Ultrasound in Obstetrics &Gynecology, Volume 66, Issue 3, Page 307-313, September 2025.
ABSTRACT Objective A surge in parvovirus B19 infections has been reported in 2023–2024 across Europe and the USA, raising concerns about the associated perinatal risks. The aim of this study was to compare perinatal outcomes following maternal parvovirus B19 infection during the 2023–2024 period with those from a pre‐2023 cohort.
S. Prasad, A. Khalil, Y. Yinon, N. Regev, R. Brawura‐Biskupski‐Samaha, M. Massoud, N. Mazanowska, F. G. Sileo, F. Prefumo, P. Kosinski, J. Morales Rosello, F. D'Antonio, Collaborators, C. Ozan Ulusoy, D. Mohammed, M. Arora, A. Hegde, E. Klapholz, C. Berkovitz, K. Kosińska‐Kaczyńska, I. Rzucidło‐Szymańska, N. Szymecka‐Samaha, S. Ceffa   +22 more
wiley   +1 more source

Cyclin Dependent Kinase 5 promotes invasion and metastasis of Hepatocellular Carcinoma [PDF]

, 2016
肝细胞癌（HepatocellularCarcinoma，HCC）在所有恶性肿瘤导致的死亡原因中占第三位，其发病率居恶性肿瘤的第六位。肝癌具有的高复发以及高转移，使肝癌愈后很差，而导致肝癌高复发和高转移的机制还不是很清楚。最近研究表明细胞周期蛋白激酶家族蛋白在上述调控过程中具有重要作用。 细胞周期素依赖蛋白激酶家族中的一个特殊蛋白：细胞周期素依赖蛋白激酶5（CyclinDependentKinase5，CDK5）引起了我们的注意，CDK5被认为主要在神经系统发挥作用。但是 ...
赵文兴
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Placental biomarker and fetoplacental Doppler abnormalities are strongly associated with placental pathology in pregnancies with small‐for‐gestational‐age fetus: prospective study

Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 6, Page 749-760, June 2025.
ABSTRACT Objective Placental dysfunction can result in small‐for‐gestational age (SGA) or fetal growth restriction (FGR). The aim of this prospective cohort study was to assess the association of the cerebroplacental ratio (CPR) and other more conventional fetoplacental Doppler indices, circulating placental growth factor (PlGF) levels and soluble fms ...
J. Hong, K. Crawford, E. Cavanagh, V. Clifton, F. da Silva Costa, A. V. Perkins, S. Kumar   +6 more
wiley   +1 more source

A preliminary study on Wee1 kinase protein stability in fission yeast [PDF]

, 2016
Wee1作为真核生物中调控细胞有丝分裂G2/M期过渡的重要激酶，它的功能可以被Cdc25磷酸酶所拮抗。如果细胞中的Wee1蛋白水平或者活性过高，细胞进入有丝分裂期延迟；而反之则G2期缩短，细胞提前进入有丝分裂期，因此在整个细胞周期中Wee1受到了非常精细地调控。高等生物中的研究表明，Wee1蛋白水平和稳定性受到了SCF的调控。为了研究裂殖酵母中参与调控Wee1激酶蛋白水平的细胞因子，本研究以裂殖酵母这一经典的单细胞真核生物为模式生物，开展了对有丝分裂G2/M过渡时期参与调控Wee1蛋白水平的因子的研究。
邱翠
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A blinded randomised split‐body clinical trial evaluating the effect of fluorescent light energy on antimicrobial management of canine interdigital furunculosis

Veterinary Dermatology, Volume 36, Issue 3, Page 291-301, June 2025.
Background – Canine interdigital furunculosis (CIF) is a complex, relapsing inflammatory condition, typically complicated by deep bacterial infections requiring prolonged systemic antibiotics. Hypothesis/Objectives – This split‐body study, where dogs acted as their own control, evaluated whether the adjunctive use of fluorescent light energy (FLE ...
A. Lange, U. Mayer, E. Bensignor, L. Cornegliani, D. Ferreira, I. Matricoti, M. Mosca, L. Ordeix, D. Pin, F. Scarampella, E. Videmont, A. Yu, O. Fantini   +12 more
wiley   +1 more source

Protein phosphatase 2A-B55δ enhances chemotherapy sensitivity of human hepatocellular carcinoma under the regulation of microRNA-133b [PDF]

, 2016
目的：原发性肝细胞癌(hepatocellularcarcinoma，HCC)是我国公共卫生关注的热点问题之一，寻找增强HCC化疗敏感性的有效干预靶点具有重要意义。蛋白磷酸酶2A(proteinphosphatase2A，PP2A)是重要的肿瘤抑制因子；PPP2R2D基因编码的PP2A-B55δ亚基参与细胞周期有丝分裂调控。我们前期研究验证了PPP2R2D基因3’-非翻译区(3’-untranslatedregion，3’UTR)的+15G>C多态性位点受微小RNA-133b(microRNA-133b，
庄群瑛
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