Results 11 to 20 of about 10,681 (157)

Targeting the PI3K/Akt signaling pathway in pancreatic β‐cells to enhance their survival and function: An emerging therapeutic strategy for type 1 diabetes 一种新兴的1型糖尿病治疗策略:靶向胰腺β细胞中的PI3K/Akt信号通路以增强其存活和功能

Journal of Diabetes, Volume 14, Issue 4, Page 247-260, April 2022., 2022
Highlights Phosphoinositide 3‐kinase (PI3K)/Akt signaling is an emerging promising therapeutic target for diabetes. Modulation of the PI3K/Akt signaling pathway, via protein and peptide‐based biologics, parasite‐derived molecules, plant extracts, or through microRNA interactions, will regulate the processes that determine the function of β‐cells and ...
Inah Camaya, Sheila Donnelly, Bronwyn O'Brien   +2 more
wiley   +1 more source

Relationships between type 2 diabetes, cell dysfunction, and redox signaling: A meta‐analysis of single‐cell gene expression of human pancreatic α‐ and β‐cells 2型糖尿病、细胞功能障碍和氧化还原信号的关系:人胰腺α‐和β‐细胞单细胞基因表达的meta分析

Journal of Diabetes, Volume 14, Issue 1, Page 34-51, January 2022., 2022
Highlights Meta‐analysis of α‐ and β‐cell transcriptomes reveals modified energy metabolism, immune response, autophagy, and cellular stress pathways in cells from type 2 diabetes mellitus. The proportion of immature and senescent β‐cells is increased in islets from type 2 diabetes mellitus.
Emily Sara Marques, Emily Formato, Wenle Liang, Emily Leonard, Alicia R. Timme‐Laragy   +4 more
wiley   +1 more source

Effect of basal insulin supplement therapy on diabetic retinopathy in short‐duration type 2 diabetes: A one‐year randomized parallel‐group trial 在短病程2型糖尿病患者的治疗方案中增加基础胰岛素对糖尿病视网膜病变的影响:一项1年随机平行对照临床研究

Journal of Diabetes, Volume 11, Issue 12, Page 949-957, December 2019., 2019
Highlights This study suggests that basal insulin‐supported oral antidiabetic drugs (OADs) therapy is superior to OADs alone in preventing diabetic retinopathy. This will help clinicians to select a suitable subsequent therapy after initial intensive insulin therapy. Abstract Background In this study, we compared the effect on diabetic retinopathy (DR)
Pan‐Wei Mu, Xi‐Xiang Tang, Ying Tan, Yi‐Na Wang, Shuo Lin, Man‐Man Wang, Jiong Shu, Jing Wang, Yong‐Jun Zhang, Hua Liang, Bai‐Run Lin, Meng‐Yin Cai, Yan‐Ming Chen   +12 more
wiley   +1 more source

Clinical Benefit of Sorafenib Combined with Paclitaxel and Carboplatin to a Patient with Metastatic Chemotherapy‐Refractory Testicular Tumors

The Oncologist, Volume 24, Issue 12, Page e1437-e1442, December 2019., 2019
Abstract Testicular cancer is one of the few tumor types that have not yet benefited from targeted therapy. Still no new active agents for treating this cancer have been identified over the past 15 years. Once patients are refractory to cisplatin‐based chemotherapy, they will be expected to die from testicular cancer.
Bijun Lian, Wenhui Zhang, Tiegong Wang, Qingsong Yang, Zepeng Jia, Huan Chen, Lei Wang, Jing Xu, Wei Wang, Kai Cao, Xu Gao, Yinghao Sun, Chengwei Shao, Zhiyong Liu, Jing Li   +14 more
wiley   +1 more source

Injectable Biomimetic Composite Hydrogel Scaffold With Tissue‐Engineered Cartilage Matrix for Articular Cartilage Regeneration

Rare Metals, Volume 45, Issue 1, January 2026.
ABSTRACT Articular cartilage regeneration remains a significant challenge because of its limited intrinsic healing capacity and the inadequacy of conventional treatments for restoring structural and functional integrity. In this study, a novel injectable composite hydrogel scaffold was designed to mimic the extracellular matrix (ECM) of native ...
Zhong‐Lian Wu, Jun‐Jie Jiang, Hang Yao, Xian‐Feng Shang, Ming‐Di Zheng, Xu Hu, Shuo Xu, Jun‐Li Shi, Yan Han, Chi‐Run Wang, Qi Tao, Huai‐Guo Xue, Dong‐An Wang, Yu‐Chi Zhao   +13 more
wiley   +1 more source

Review of additively manufactured zinc alloys by laser powder bed fusion for biomedical applications

Rare Metals, Volume 44, Issue 11, Page 8262-8291, November 2025.
Graphical abstract AbstractZinc (Zn) and its alloys have emerged as promising candidates for biomedical materials, owing to their controlled degradation kinetics, intrinsic biocompatibility, and the release Zn2+ ions which are known to promote bone regeneration and tissue healing.
Xuan Yang, Zaimao Peng, Yan Fang, Yunlong Tang, Hsin‐Hui Shen, Yuman Zhu   +5 more
wiley   +1 more source

Effect of a ceruminolytic ear cleaner on clinical, microbiological and ear canal microbiome evolution in canine erythemato‐ceruminous otitis externa associated with proliferation of Malassezia yeasts

Veterinary Dermatology, Volume 36, Issue 5, Page 668-678, October 2025.
Background – Erythemato‐ceruminous otitis externa (ECOE) is commonly associated with Malassezia spp. and microbial imbalance. Hypothesis/Objective – To assess the clinical performance of an ear cleaner in dogs suffering from ECOE associated with Malassezia spp. overgrowth and to measure its impact on the microbiota. Conclusions and Clinical Relevance –
Amaury Briand, Emmanuel Bensignor, Hélène Dropsy, Odile Crosaz, Louis Humeau, Justine Cheval, Vanessa Demontant, Melissa N. Debi, Oscar Fantini, Hélène Dal, Jacques Guillot, Noelle Cochet Faivre   +11 more
wiley   +1 more source

Amplification of Ovis aries papillomavirus type 2 DNA from an ovine cutaneous fibropapilloma

Veterinary Dermatology, Volume 35, Issue 2, Page 226-229, April 2024.
Seven of 60 Perendale sheep within a flock developed single or multiple exophytic masses on their distal hind limbs. A mass was excised from one sheep and histological evaluation revealed epidermal and mesenchymal proliferation, papillomavirus‐induced keratinocyte changes and marked keratohyalin clumping.
John S. Munday, Hanna J. Klobukowska, Karen Nicholson   +2 more
wiley   +1 more source

枸杞多糖增强效应T细胞增殖和杀瘤活性机制的研究

Zhongguo shiyan zhenduanxue, 2010
目的观察枸杞多糖对效应T细胞增殖和杀瘤活性机制的作用。方法通过密度梯度离心法分离人外周血单核细胞并培养其为树突状细胞,用冻融法制备肝癌细胞的全抗原并致敏树突状细胞;通过混合淋巴细胞实验,获取树突状细胞激活的特异性效应T细胞。用MTT法测定效应T细胞对肝癌细胞的杀伤率。观察枸杞多糖在树突状细胞的成熟及T细胞的激活、增殖和杀瘤过程中的作用。结果枸杞多糖单独对T细胞无明显的增殖能力,但能促进树突状细胞的成熟并且能增强效应T细胞的增殖能力和杀瘤活性 ...
王晓华, 单铁英, 侯永超, 杨书良   +3 more
doaj  

Yap Regulates ATF6-Mediated Unfolded Protein Response [PDF]

, 2015
Hippo信号通路最早在果蝇里发现，是在进化上高度保守的一条激酶级联的通路，当Hippo通路的缺失会造其下游调控因子Yap或Taz的激活，促进细胞增殖，抑制细胞凋亡，从而导致器官增大和肿瘤产生。此外，大量文献阐述了内质网压力和肿瘤产生具有相关性。本实验室研究表明，Hippo通路的缺失或Yap蛋白的激活会引起内质网应激信号通路的激活和内质网的增大，并通过内质网应激反应导致肝脏器官增大和肿瘤生成。 当Hippo激酶，在高等动物的同源物为Mst1和Mst2激酶的缺失或Yap激活时 ...
蔡亚波
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