Results 11 to 20 of about 12,378 (161)
Veterinary Dermatology, Volume 34, Issue 5, Page 425-440, October 2023., 2023 Background – While the clinical features were described recently, the histopathological characterisation of trunk‐dominant canine pemphigus foliaceus (PF) is lacking, and whether it differs from classic facial or insecticide‐triggered PF is unknown. Hypothesis/Objectives – This study describes the histopathological findings of trunk‐dominant PF, and ...
Natalie Katharina Yvonne Gedon +6 more
wiley +1 more source
Renoprotective effects of brown adipose tissue activation in diabetic mice 棕色脂肪激活对糖尿病小鼠的肾脏保护作用
Journal of Diabetes, Volume 11, Issue 12, Page 958-970, December 2019., 2019 Highlights This study demonstrates that of brown adipose tissue (BAT) with CL316,243 attenuates the progress of diabetic kidney disease (DKD). Mechanistically, the activation of BAT improved concentrations of circulating adipokines and microRNAs, which further affected the diabetic kidney and reactivated the AMP‐activated protein kinase/sirtuin 1 ...
Ying‐Ying Cai +10 more
wiley +1 more source
Developmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019 目的 本国际临床指南由欧洲残疾儿童学会（the European Academy of Childhood Disability，EACD）牵头制定，旨在解决发育性协调障碍（developmental coordination disorder，DCD）的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题，通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础，以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类，最终转化为指南建议。并由国际 ...
Jing Hua +6 more
wiley +1 more source
Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 3, Page 376-384, March 2026.ABSTRACT Objective To investigate whether combining abnormal morphological features observed on ultrasound in live pregnancies that ended in a first‐trimester miscarriage can predict an abnormal karyotype. Methods This retrospective observational cohort study was conducted at the early‐pregnancy assessment unit at University College London Hospital ...
T. Setty +5 more
wiley +1 more source
Integrative Conservation, Volume 4, Issue 4, Page 665-674, December 2025.Using a diagnostic mitochondrial marker gene, we document the presence of furry‐eared dwarf lemurs, a species known from Madagascar's eastern montane rainforests, in several forest fragments across the island's central highlands. These findings raise new questions about when this species colonized these sites, how they tolerate these changing and ...
Marina B. Blanco +27 more
wiley +1 more source
A new beef: An analysis of discourse coalitions in the nascent cellular agriculture policy subsystem
Review of Policy Research, Volume 42, Issue 6, Page 1404-1427, November 2025.Abstract A robust approach to examining the nature and influence of coalitions in the policy process is the Advocacy Coalition Framework (ACF), which is especially useful to study policy issues fraught with scientific and technical controversy. Yet, important gaps exist in ACF literature regarding nascent policy subsystems. Consequently, there is scant
Nikki Nadeau, Ramiro Berardo
wiley +1 more source
Anti-tumor Activities of Marine Natural Product Lagunamide A: A Mechanism Study [PDF]
, 2016 本研究以海洋天然产物为对象，系统地分析了lagunamideA及其5个类似物抑制多种肿瘤细胞（A549、HeLa、U2OS、HepG2、BEL-7404、BGC-823、HCT116、MCR-7、HL-60与A375）生长的构效关系，结果表明，C-39位的R构型对活性的保持具有至关重要的作用。在A549细胞中进行的进一步机理研究表明，lagunamideA诱导了caspase依赖性的细胞凋亡。它通过降低膜电位（Δφm），产生大量活性氧（ROS），引起线粒体功能障碍，最终导致细胞死亡 ...
黄伟
core
37例以孤立性头昏为表现的病毒性脑炎特点和误诊分析 [PDF]
目的研究以孤立性头昏为表现的病毒性脑炎患者的临床特点，分析前庭功能检查、脑脊液细胞学等对这类患者的诊断效能。方法收集以孤立性头昏为表现的病毒性脑炎患者37例，健康志愿者10名。收集患者临床资料如眩晕障碍量表（ DHI）评分、头部影像学、脑电图、前庭功能检查、脑脊液常规、生化、细胞形态学、病原学二代测序、误诊情况等。分析各类检查对患者诊断价值的ROC曲线下面积（AUC）。对比治疗前后各检查的变化情况。结果89.19%（33/37）患者的初步诊断存在误诊。64.86%（24/37 ...
周香雪, 许少华, 钟威
core +1 more source
Veterinary Dermatology, Volume 36, Issue 5, Page 696-702, October 2025.Background – Skin disease is a common complaint in veterinary medicine. Current models often use live animals. Epidermal organoids (keratinocytoids) are 3D miniature organs created in culture from single epidermal keratinocytes. These keratinocytoids can be used as an alternative to live animal studies to investigate epidermal structures and skin ...
Clinson C. Lui +5 more
wiley +1 more source
Molecular mechanism of inhibitory effect of lipoxin A4 on estrogen-induced epithelial to mesenchymal transition (EMT) in endometriosis [PDF]
, 2016 子宫内膜异位症，简称内异症（Endometriosis，EM），是育龄妇女的常见病，它是指具有活性的子宫内膜出现在子宫腔以外所引起的一种病变。人群发病率高达10%-15%。其典型症状为不孕和疼痛，严重影响患者的生活质量和家庭和谐，尤其是高达50%的复发率，给家庭和社会带来沉重的经济负担。这一系列防治难题的根本原因在于发病机制尚不明确。解析内异症的发病机制，进而寻找新的药物靶点和安全高效的治疗方法具有重大意义。 本论文首先以临床内异症患者在位/异位子宫内膜组织及非内异症患者子宫内膜组织为研究对象 ...
吴荣锋
core