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Systematic review of shared decision‐making in guidelines about colorectal cancer screening
European Journal of Cancer Care, Volume 31, Issue 6, November 2022., 2022 Abstract Introduction We aimed to systematically evaluate quality of shared decision‐making (SDM) in colorectal cancer (CRC) screening clinical practice guidelines (CPGs) and consensus statements (CSs). Methods Search for CRC screening guidances was from 2010 to November 2021 in EMBASE, Web of Science, MEDLINE, Scopus and CDSR, and the World Wide Web ...
Marta Maes‐Carballo +6 more
wiley +1 more source
Impact of commonly prescribed drugs on the risk of colorectal cancer [PDF]
, 2023 Colorectal cancer (CRC) stands as the fourth most prevalent cancer worldwide and the third most common in Sweden. Characterized by a protracted progression stage and insidious onset, CRC poses a considerable challenge for early detection.
Liu, Qing
core +1 more source
The Oncologist, Volume 24, Issue 11, Page 1416-1419, November 2019., 2019 Abstract Immune checkpoint blockade (ICB) is an approved therapy for advanced metastatic mismatch repair (MMR)‐deficient cancer regardless of tissue of origin. Although therapy is effective initially, recurrence rates are significant, and long‐term outcomes remain poor for most patients.
Arthur Winer +7 more
wiley +1 more source
The Oncologist, Volume 23, Issue 1, Page 7-15, January 2018., 2018 Abstract Background This study compared the efficacy of regorafenib and trifluridine/tipiracil (TFTD) in patients with metastatic colorectal cancer (mCRC) who are refractory to standard chemotherapy, because despite their clinical approval, it still remains unclear which of these two drugs should be used as initial treatment.
Toshikazu Moriwaki +25 more
wiley +1 more source
Clinical features and prognosis in patients with lung metastases from colorectal cancer [PDF]
, 2017 目的探讨结直肠癌肺转移患者的临床特征及预后生存分析。方法选取2008年1月至2014年1月间福建医科大学附属第一医院收治的146例结直肠癌肺转移患者的临床资料及随访资料,分析患者的临床特征及影响结直肠癌肺转移患者预后的相关因素。结果患者中位随访时间为35.1个月,中位生存时间为27.1个月,1年、3年和5年生存率分别为75.3%、30.8%和12.4%。病理组织分级、TNM肿瘤分期、肺转移灶大小、肺转移灶数目、是否合并肝转移和治疗方式不同的结直肠癌肺转移患者,预后生存时间差异均有统计学意义（均P〈0 ...
傅启全, 凌浩, 董长女
core +1 more source
Correlation of LC3 and the recruitment of dendritic cell and the formation of TLS in colorectal cancer and its clinical significance [PDF]
, 2023 Background and purpose: It has been recognized as a complex problem in tumor therapy to deal with the tumor immune escape, and over-activated autophagy can cause the increase of tumor surface antigen, which participates in anti-tumor immunity.
WU Han, XU Lei, WANG Miaomiao, ZHANG Ruizhe, XU Xiaoyang, GUO Ningjie, WU Shuhua
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Zhongguo shiyan zhenduanxue, 2022 目的 探究釉丛蛋白1(TUFT1)在直肠癌组织中的表达水平及其对直肠癌的诊断和预后价值。方法 利用Ualcan数据库分析TUFT1 mRNA在正常直肠组织及直肠癌组织中的表达水平；选取2014年12月～2018年4月新乡市第一人民医院诊治的77例直肠癌患者为研究对象，实时荧光定量PCR(qRT-PCR)法测定直肠癌组织、癌旁正常组织TUFT1 mRNA表达水平；分析直肠癌组织TUFT1 mRNA表达水平与直肠癌患者临床病理特征的关系；受试者工作特征曲线(ROC曲线)评价直肠组织TUFT1 ...
王坤, 张玉盼, 杨亚鹏
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Crosstalk between epigenetic modification and circRNA in colorectal cancer: recent advances [PDF]
, 2023 Colorectal cancer (CRC) is generally regarded as the third frequent malignancy worldwide, while current diagnosis and treatment of the disease are limited.
PENG Tian, XU Leiming
core +1 more source
Zhongguo shiyan zhenduanxue, 2023 结直肠癌作为癌症相关死亡的第四大原因，也是全球第三大最常诊断的恶性肿瘤。在东欧和亚洲地区，结直肠癌的发病率和死亡率上升迅速，预计到2030年，全球结直肠癌患者将新增220万确诊病例以及110万的死亡病例[1]。在最近的研究报告中指出进行结直肠癌早期癌症筛查诊断能显著降低结直肠癌死亡率[2],本实验初步通过二维色谱质谱联用技术及免疫印迹实验来分析RPS14蛋白在结直肠癌组织与癌旁组织的差异，为结直肠癌的筛查和诊断提供帮助。
岳斯琦, 魏丽萍, 何成彦
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Zhongguo shiyan zhenduanxue, 2023 目的 探讨结直肠癌组织和细胞中人整合素α6的表达特点及作用。方法 以人结直肠癌细胞株HT-29、RKO,人永生化结肠上皮细胞系IMCE,以及结直肠癌组织和癌旁正常组织为研究对象。Western blot检测整合素α6在结直肠癌组织和癌细胞中的表达特点；使用整合素α6慢病毒过表达载体转染结直肠癌细胞，进行Transwell细胞迁移和侵袭实验；同时检测整合素α6过表达对结直肠癌细胞E-钙黏蛋白、N-钙黏蛋白、波形蛋白、p-Smad2及Smad2蛋白表达水平。结果 结直肠癌HT-29细胞 ...
邢艳丽 +4 more
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