[Associations of circulating leptin levels with colorectal adenoma and colorectal cancer: a case-control and Mendelian randomization study]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Zhao H +7 more
europepmc +1 more source
Research of diagnostic biomarkers in Breast cancer and Gastric cancer [PDF]
, 2013 自生物标志物（biomarker）这一概念提出以来，肿瘤生物标志物（tumorbiomarker，TBM）在基础医学领域的研究已成为热点。本文基于大量的临床病理样本，利用免疫组织化学、甲基化芯片分析、实时荧光定量PCR等技术，研究乳腺癌、胃癌预后诊断的生物标志物，为疾病的治疗提供新的思路和靶点。 我们利用免疫组织化学，调查了酪氨酸磷酸酶Shp2和它的伴侣蛋白Gab2在141例乳腺浸润性导管癌中的表达，并分析了他们与临床病理学特征的相关性，发现Gab2蛋白表达与病人的年龄存在显著相关性 ...
陈宝珍
core
The characteristics of the optimal beneficiary population for robotic⁃assisted radical resection of colorectal cancer [PDF]
Objective To compare the impact of robotic-assisted versus laparoscopic-assisted radical resection for colorectal cancer on perioperative outcomes using propensity score matching（PSM），and to explore the optimal patient population for robotic surgery ...
LI Hang*，GU Haitao，LI Dongxue，XIAO Minfeng
core +2 more sources
Zhongshan Daxue xuebao. Yixue kexue ban, 1983 近二、三十年来,手术治疗结、直肠癌的疗效并无显著提高。因为结、直肠癌患者被作出诊断时,约有50%以上已发生转移,所以单靠扩大切除范围来改善预后,显属不能。因此,不少医学家探索应用化疗等措施作为提高大肠癌根治术疗效的辅助治疗。 我院自1972年开始应用Rousselot介绍的肠腔化疗方法,作为结、直肠癌根治切除的辅助疗法。本文总结了8年间的经验,旨在探索提高结、直肠癌根治术疗效的措施。
万德森
doaj
[Influencing Factors of Adherence to Exercise Prehabilitation in Older Patients With Colorectal Cancer: A Qualitative Study]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue Ban, 2023 Wang X, Zhu X, Wu Q.
europepmc +1 more source
Zhongguo shiyan zhenduanxue, 2012 目的探讨血管紧张素原（AGT）基因M235T多态性与中国人群结直肠癌易感性的关系。方法采用聚合酶链反应-限制性片段长度多态性方法检测结直肠癌组151例患者和健康对照组202例AGT基因M235T多态性。结果结直肠癌组与对照组AGT20M235T基因型和等位基因分布差异无统计学意义（P>0.05）。根据临床病理特征进行分层分析,发现携带TT基因型个体患低分化结直肠癌的风险比携带MT/MM基因型高2.50倍（P=0.008,OR=2.50;95%CI,1.26-4.97 ...
侯波
doaj
Application of immune checkpoint inhibitors in colorectal cancer. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2021 Wang L, Huang C.
europepmc +1 more source
[LINC01285 promotes proliferation and metastasis of colorectal cancer cells by regulating epithelial-mesenchymal transition]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2022 Zhu X +5 more
europepmc +1 more source
转化生长因子β1基因-509C/T多态性与结直肠癌关系的研究
Zhongguo shiyan zhenduanxue, 2012 目的研究转化生长因子β1(TGF-β1)基因启动子-509C/T多态性与结直肠癌的关系。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,检测118例结直肠癌患者和130例健康对照者转化生长因子β1的基因多态性,同时采用酶联免疫吸附试验(ELISA)检测血清TGF-β1水平。结果结直肠癌患者血清TGF-β1水平显著高于对照组(49.37±8.32μg/L VS 21.38±6.25μg/L ...
唐任光 +7 more
doaj
[Metformin inhibits self-renewal of colorectal cancer stem cells by inhibiting mitochondrial oxidative phosphorylation]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Yan C, Liu S, Song Q, Hu Y.
europepmc +1 more source