Results 81 to 90 of about 807 (103)
Zhongshan Daxue xuebao. Yixue kexue ban, 1983 近二、三十年来,手术治疗结、直肠癌的疗效并无显著提高。因为结、直肠癌患者被作出诊断时,约有50%以上已发生转移,所以单靠扩大切除范围来改善预后,显属不能。因此,不少医学家探索应用化疗等措施作为提高大肠癌根治术疗效的辅助治疗。 我院自1972年开始应用Rousselot介绍的肠腔化疗方法,作为结、直肠癌根治切除的辅助疗法。本文总结了8年间的经验,旨在探索提高结、直肠癌根治术疗效的措施。
万德森
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The Role of SRC-3 in Carcinogenesis of Colorectal Cancer [PDF]
, 2011 结直肠癌（Colorectalcancer，CRC）是一种常见的恶性肿瘤，目前结直肠癌是世界上发病率和死亡率最高的恶性肿瘤之一。这种癌症往往是自发性的或者是由长期的肠道炎症如Crohn氏疾病、溃疡性肠炎导致的。 SRC-3（Steroidreceptorcoactivator3），即AIB1（Amplifiedinbreastcancer1），是p160共激活子家族的一员。SRC-3被报道在多种肿瘤的恶化过程中起到重要的作用，如乳腺癌和前列腺癌，然而SRC-3在结直肠癌中的功能尚不清楚。 在本研究中 ...
管磊
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Zhongguo shiyan zhenduanxue, 2012 目的探讨血管紧张素原（AGT）基因M235T多态性与中国人群结直肠癌易感性的关系。方法采用聚合酶链反应-限制性片段长度多态性方法检测结直肠癌组151例患者和健康对照组202例AGT基因M235T多态性。结果结直肠癌组与对照组AGT20M235T基因型和等位基因分布差异无统计学意义（P>0.05）。根据临床病理特征进行分层分析,发现携带TT基因型个体患低分化结直肠癌的风险比携带MT/MM基因型高2.50倍（P=0.008,OR=2.50;95%CI,1.26-4.97 ...
侯波
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Surgical management of liver metastases from colorectal cancer [PDF]
With the persistent rise in colorectal cancer incidence，approximately 50% of patients develop liver metastases during the disease course. According to international staging systems，colorectal cancer liver metastases（CRLM）are classified as advanced-stage ...
JI Jiuwei，ZHANG Yonggang，WANG Hongwei
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转化生长因子β1基因-509C/T多态性与结直肠癌关系的研究
Zhongguo shiyan zhenduanxue, 2012 目的研究转化生长因子β1(TGF-β1)基因启动子-509C/T多态性与结直肠癌的关系。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,检测118例结直肠癌患者和130例健康对照者转化生长因子β1的基因多态性,同时采用酶联免疫吸附试验(ELISA)检测血清TGF-β1水平。结果结直肠癌患者血清TGF-β1水平显著高于对照组(49.37±8.32μg/L VS 21.38±6.25μg/L ...
唐任光 +7 more
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Expressions of Cyr61 and WISP-3 in Non-small Cell Lung Cancer and Its Clinical Significance [PDF]
, 2010 Background and objective Cysteine-rich protein 61 (Cyr61) plays a role as a tumor suppressor in non-small cell lung cancer (NSCLC). Cyr61 and WISP-3 have a very significant sequence homology, belonging to the same CCN gene family.
Chunwei ZHANG +3 more
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A New Chapter in Colorectal Cancer Treatment: Insights from 2024 ASCO Annual Meeting [PDF]
At the 2024 Annual Meeting of the American Society of Clinical Oncology (ASCO), multiple research achievements in the field of colorectal cancer were announced. This article summarizes and interprets the research results related to colorectal cancer from
Guanghai DAI, Miaomiao GOU, Zhikuan WANG
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Zhongguo shiyan zhenduanxue, 2012 目的探讨结直肠癌淋巴结转移度（lymph node ratio,LNR）的相关临床病理因素。方法回顾性分析吉林大学中日联谊医院结直肠肛门外科2009年9月至2011年9月间手术治疗的135例结直肠癌病例资料,采用单因素分析方法,研究结直肠癌LNR与临床病理因素之间的关系。结果性别、年龄、肿瘤大小、大体类型与结直肠癌LNR无关,而术前中性粒细胞和淋巴细胞比值（neutrophil-to-lymphocyteratio,NLR）、肿瘤部位、肿瘤分化程度、浸润深度显著与LNR有关 ...
董典博 +3 more
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Over-expression of Smad4 could prevent migration and invasion in colon cancer SW480 and SW620 cells [PDF]
, 2016 结直肠癌（CRC）新发病率及死亡率在男性女性中均位于第三位，近几年发病率及死亡率呈上升趋势，远处转移尤其肝脏转移为主要死亡原因。研究证实，转化生长因子β1（TGF-β1）在不同的结直肠癌细胞中可以诱导上皮间质化（EMT），上皮间质化（EMT）是肿瘤细胞转移过程中普遍发生的现象；Smad4是TGF-β1作用中的调节枢纽：当Smad4表达时，TGF-β1/Smad4起到抑制转移作用，当Smad4表达缺失时，Smad4非依赖通路活性增强并促进癌细胞转移。据文献报道，EPHA2在多种肿瘤中高表达 ...
刘中财
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Intratumoral Microbiota Promotes Tumor Progression by Modulating Tumor Metabolism [PDF]
A wealth of prior studies has confirmed that intratumoral microbiota can survive within tumor tissue, thereby promoting or inhibiting tumor growth. With the development of high-throughput sequencing and metabolomics, increasing attention has been paid to
Liyuan FANG +4 more
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