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Zhongshan Daxue xuebao. Yixue kexue ban缺血性脑卒中（CIS）是指因脑部血液循环障碍，缺血、缺氧所致的局限性脑组织的缺血性坏死或软化，其发病率在脑血管病中占据首位。氧气和营养供应的减少会导致神经元的严重丧失，并导致中风患者脑功能的缺陷。开发缺血性脑卒中的治疗方法仍然是临床医学的重要挑战。抗氧化剂N-乙酰半胱氨酸（NAC）是谷胱甘肽前体物质，缺血性脑卒中动物模型及一些临床研究的证据表明，NAC可以有效地保护大脑免受缺血损伤。本文从抗氧化、抑制炎症、保护脑神经和线粒体功能、稳定动脉斑块及溶栓功能等多方面阐述NAC在CIS中的作用机制 ...
杨晨, 万文辉
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Association of glycemic gap with stroke recurrence in patients with ischemic stroke. [PDF]
J Diabetes, 2023 Highlights There was a U‐shaped relationship between glycemic gap and stroke recurrence during a long‐term follow‐up in a Chinese ischemic stroke registry. Clinical physicians should remain vigilant in the fluctuation of glucose level and use individualized glucose control strategies in patients with ischemic stroke.
Yuan K +10 more
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Zhongguo cuzhong zazhi静脉溶栓治疗是急性缺血性卒中患者恢复脑血流灌注最主要的措施之一，目前急性缺血性卒中相关诊疗指南多建议在静脉溶栓后24 h后启动抗血小板治疗。然而，研究显示急性缺血性卒中患者静脉溶栓后至启动二级预防前，仍有症状加重和病情反复的风险。针对静脉溶栓后仍然呈现病情进展的急性缺血性卒中患者，若早期启动包括抗血小板治疗在内的二级预防，有望改善其预后。本文对近年来有关急性缺血性卒中患者静脉溶栓后24 h内启用抗血小板治疗的相关研究进行综述，以期为缺血性卒中患者溶栓后的治疗策略提供参考。Abstract ...
李子恒，刘毅（LI Ziheng, LIU Yi）
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Zhongguo cuzhong zazhi, 2019 【摘要】 目的 探讨急性缺血性卒中90 d内复发与TC/HDL-C比值的关系。 方法 利用急性缺血性卒中患者氧化应激水平临床观察研究（Study on Oxidative Stress in Patients with Acute Ischemic Stroke，SOS-Stroke）数据库的3605例患者作为研究对象，采用多因素Logistic回归分析急性缺血性卒中患者90 d卒中复发的影响因素。 结果 该研究人群中有231例（6.40%）患者90 d卒中复发 ...
王林玉，韩坤强，管生，李振东
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Zhongshan Daxue xuebao. Yixue kexue ban, 2019 血脑屏障（BBB）是以内皮细胞为核心形成的维持中枢神经系统微环境稳态的重要结构。在缺血性卒中的病理条件下，局部的各种炎症反应与细胞自身表型、结构的改变使BBB的完整性遭到破坏、通透性上升，外周血中的各种成分，尤其是激活的炎症细胞/炎症因子可穿过受损的BBB而到达脑实质并损害正常或加重已经受损的神经细胞的功能。本文通过描述BBB各组分的和其他炎症细胞的激活和功能改变来回顾缺血性卒中后BBB的受损机制，并简要总结我们团队目前修复缺血性卒中后BBB损伤的相关工作。
陆正齐
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Journal of Diabetes, Volume 15, Issue 4, Page 289-298, April 2023., 2023 Highlights This long‐term longitudinal study demonstrates the association between alcohol consumption and health outcomes in patients with abnormal glucose metabolism including type 2 diabetes mellitus and prediabetes. Occasional drinking (less than once a week) reduces the risk of all‐cause mortality, while heavy alcohol consumption (≥30 g/day for men
Mengzhao Cui +7 more
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Journal of Diabetes, Volume 14, Issue 8, Page 495-513, August 2022., 2022 Highlights During the past 30 years, globally, the disease burden of stroke burden has decreased substantially; however, the disease burden of stroke attributable to high fasting plasma glucose (HFPG) failed to achieve a significant decline. The population‐attributable fraction of HFPG for stroke burden has been increasing across different regions ...
Yang Liu +8 more
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Journal of Diabetes, Volume 13, Issue 12, Page 1034-1042, December 2021., 2021 Highlights The impact of stress‐induced hyperglycemia on outcome is poorly reflected by absolute glucose levels. The stress hyperglycemia ratio (SHR) biomarker discriminates between interpatient variation in normal premorbid background glycemia related to glycosylated hemoglobin and the acute relative increase in glucose related to physiological stress
Gregory Roberts +7 more
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The Anatomical Record, Volume 304, Issue 11, Page 2538-2551, November 2021., 2021 Abstract This study aimed to explore the changes in functional connections between cerebral hemispheres and local brain regions functional activities in patients with acute ischemic stroke (AIS) treated with International Standard Scalp Acupuncture (ISSA).
Huacong Liu +11 more
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MMC celebrating 6 years of experience and expansion 庆祝MMC六年的经验和壮大
, 2022 Journal of Diabetes, Volume 14, Issue 5, Page 356-357, May 2022.
Itamar Raz
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