Results 51 to 60 of about 5,998 (191)
ER stress及PUMA对5-FU诱导的肝脏细胞损伤与凋亡的影响
Zhongshan Daxue xuebao. Yixue kexue ban, 2019 【目的】探讨内质网应激（ERS）及p53上调凋亡调控因子（PUMA）在5-氟尿嘧啶（5-FU）诱导的肝脏细胞的损伤与凋亡中发挥的作用。【方法】给予10只PUMA基因敲除小鼠（PUMA-KO）和20只野生型小鼠（PUMA-WT）腹腔注射等剂量的5-FU，建立小鼠肝脏损伤模型，其中10只WT小鼠同时给予腹腔注射ERstress抑制剂4-苯基丁酸（4-PBA），对照组10只KO小鼠及20只WT小鼠给予等量生理盐水，造模完成后收集小鼠的血清及肝脏组织，评估肝脏病理损伤程度 ...
刘珊 +4 more
doaj
Protective effect of Axin against acetaminophen-induced acute liver injury via promoting GSH synthesis [PDF]
, 2017 Axin作为一个多功能的构架蛋白，参与调节Wnt，AMPK，mTOR，JNK和P53等多种信号通路，对维持细胞物质和能量代谢的平衡有重要作用。Axin全身敲除致死，目前人们对Axin在组织和器官水平中所扮演的角色了解的并不多。我们成功构建了肝脏特异性敲除Axin基因的小鼠，肝脏是机体最大的解毒器官同时也是物质代谢的核心场所，其正常运作对维持健康至关重要。 过量服用对乙酰氨基酚会诱发急性肝损伤，这是因为毒性代谢物耗竭谷胱甘肽后会直接攻击肝细胞，同时启动各种应激途径进而导致细胞死亡 ...
林慧格
core
Role of ferroptosis in acute cadmium-induced liver injury in mice [PDF]
Objective To investigate the role of ferroptosis in acute liver injury induced by cadmium (Cd) exposure in mice. Methods Healthy and clean male ICR mice of 8-10 weeks were randomly divided into control group, and Cd exposure group.
GUO Siyu +6 more
core +1 more source
[Spectrum-effect relationship of total anthraquinone extract of Cassia seeds against fluorouracil-induced liver injury in mice]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Wang H +7 more
europepmc +1 more source
Mechanistic study on the alleviation of LPS-induced hepatocyte injury by thymic stromal lymphopoietin [PDF]
Objective To explore the mechanism of thymic stromal lymphopoietin (TSLP) in regulating lipopolysaccharide (LPS) -induced inflammation in mouse hepatocytes. Methods Ten male C57BL/6J wild-type (WT) mice and 10 male TSLP receptor-deficient (TSLPR-/-) mice
Jiarui ZHANG, Shaolei WU, Shilai LI
core +1 more source
Zhongguo shiyan zhenduanxue, 2009 目的探讨结核患者短期化疗所引起的肝损伤情况。方法516例结核患者检测其肝功能以及各型肝炎标志物。结果肝损害的发生率为16.3%,有基础性肝病与无肝炎病史的患者相比较,肝损害的发生率显著增高（χ2=22.73,P0.05）。60岁以上的老人化疗后肝损害的发生率明显高于60岁以下的人群（χ2=6.05 ...
侯远沛 +4 more
doaj
Deficiency in glutathione synthesis and reduction contributes to the pathogenesis of colitis-related liver injury. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2022 Wang L, Han R, Zang K, Yuan P, Qin H.
europepmc +1 more source
大豆异黄酮对肝纤维化大鼠肝损伤保护作用的实验研究 [PDF]
, 2010 目的观察大豆异黄酮(SI)对实验性肝纤维化大鼠肝损伤的保护作用,为进一步研究SI抗肝纤维化作用提供实验依据。方法采用CCl4诱导的肝纤维化大鼠模型,造模同时用SI水溶液10ml/kg·d(90mg/kg·d)灌胃进行早期干预,检测血清肝功能(ALT、AST、ALB、TP),光镜下观察肝组织病理变化及炎症活动度。结果SI可明显降低大鼠血清ALT、AST水平,升高血清ALB、TP水平,减轻肝实质的炎症病理损伤。结论SI具有一定的保肝护肝作用 ...
张永生 +4 more
core
双环醇对抗精神病药物所致肝损伤患者血清MDA及SOD活性的影响
Zhongguo shiyan zhenduanxue, 2014 药物性肝损伤是由于多种因素参与通过多条途径的复杂过程,不仅与年龄、性别、机体营养状态和遗传背景有关,与药物的剂量、疗程及药物的分子结构、合用药物和酒精等因素也有关联。研究表明[1],自由基与脂质过氧化作用在药物性肝损伤发生中的作用越来越受到重视。我们前期研究发现,双环醇用于治疗抗精神病药物所致肝损伤的显效率和有效率均高于甘草酸二胺胶囊,且对患者肝功能指标ALT、AST和γ-GT改善更明显 ...
刘建国 +4 more
doaj
[Effects and mechanism of diammonium glycyrrhizinate on liver injury in severely scalded rats]. [PDF]
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi, 2022 Xie CQ +7 more
europepmc +1 more source