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ER stress及PUMA对5-FU诱导的肝脏细胞损伤与凋亡的影响 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2019 【目的】探讨内质网应激（ERS）及p53上调凋亡调控因子（PUMA）在5-氟尿嘧啶（5-FU）诱导的肝脏细胞的损伤与凋亡中发挥的作用。【方法】给予10只PUMA基因敲除小鼠（PUMA-KO）和20只野生型小鼠（PUMA-WT）腹腔注射等剂量的5-FU，建立小鼠肝脏损伤模型，其中10只WT小鼠同时给予腹腔注射ERstress抑制剂4-苯基丁酸（4-PBA），对照组10只KO小鼠及20只WT小鼠给予等量生理盐水，造模完成后收集小鼠的血清及肝脏组织，评估肝脏病理损伤程度 ...
刘珊 +4 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2015 摘 要: 【目的】 探讨磁共振IDEAL-IQ序列对肝脏脂肪变性和铁过载的诊断价值?【方法】 对20例脂肪肝患者(脂肪肝组),20例地中海贫血反复输血患者(贫血组),以及20例健康体检者(对照组)行3.0T MRI的IDEAL-IQ序列扫描,通过脂肪比像?R2*弛豫率像对肝脏的脂肪含量?铁含量进行定量测定?【结果】 脂肪肝组的肝脏脂肪含量为(15.28±5.75)%,对照组的脂肪含量为(3.45±1.81)%,两者之间差异有统计学意义?贫血组的肝脏R2*值为(592±115)Hz,对照组R2*值为 ...
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Zhongshan Daxue xuebao. Yixue kexue ban, 2008 【目的】探讨七氟烷和异氟烷预处理对大鼠肝脏缺血再灌注损伤(I/R)的保护作用及机制。【方法】96只SD大鼠随机分为假手术对照组(Sham)、肝脏缺血再灌注组(IR)、七氟烷预处理(Sev)和异氟烷预处理组(Iso),于肝脏缺血30min,再灌注30min、120min测各组大鼠血清中谷丙转氨酶(ALT)、谷草转氨酶(AST)、乳酸脱氢酶(LDH)的含量以及肝脏组织中谷胱甘肽(GSH)、丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性。【结果】肝脏缺血再灌注后IR、Sev和Iso组血清ALT ...
王旭东, 卢雅立, 王飞, 李艳萍
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野生动物学报, 2007 初步分析黑龙江林蛙肝脏可溶性蛋白在聚丙烯酰胺凝胶电泳（PAGE）上的分布及低温胁迫下黑龙江林蛙肝脏可溶性蛋白的适应性变化。结果表明:分离胶浓度为6％的肝脏电泳图谱分辨率高、条带多,可分辨出约15～19条谱带;1℃环境温度胁迫条件的黑龙江林蛙肝脏Rf约0．79的可溶性蛋白含量较室温条件下的含量有所增加（P< 0．05）,而随机选取的三组蛋白含量并无显著性差异（P0.10>0．05,P0.42>0．05,P0.84>0．05）。
孙雪玲, 肖向红, 王昊
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Zhongshan Daxue xuebao. Yixue kexue ban, 2011 【目的】 探讨肝脏移植术后移植物抗宿主病（GVHD）的诊断和治疗。【方法】 分析我院2003年10月至2009年6月完成的772例肝脏移植的临床资料，总结肝脏移植术后GVHD的诊断和治疗经验。【结果】 772例肝脏移植术后5例病人发生GVHD，发病率为0.65%（5/772），5例患者均在肝脏移植后2～5周出现发热、皮疹、腹泻和全血细胞减少，肝功能均接近正常，经皮肤活检和骨髓穿刺检查证实，并排除巨细胞病毒（CMV）和EB病毒感染。经过调整免疫抑制剂，加用IL-2受体单克隆抗体，积极抗感染和支持对症治疗 ...
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Journal of Diabetes, Volume 15, Issue 9, Page 777-786, September 2023., 2023 Highlights Increased glutamate is associated with the development of diabetes. Glutamate increases plasminogen (PLG) levels through glutamate metabotropic receptor 5 activation with various insulin resistance‐related stresses. Glutamate inhibits the conversion of PLG to plasmin by increasing plasminogen activator inhibitor‐1.
Hyo Jung Lee +7 more
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Journal of Diabetes, Volume 15, Issue 2, Page 165-180, February 2023., 2023 Highlights For the first time, our study contributed a systematic evaluation of bile acid (BA) profiles in plasma, feces and liver tissue and gut microbiota changes triggered by fasting‐refeeding cycle in mice. Our work clearly demonstrated that overnight fasting leads to significant, but reversible changes in BA profiles and gut microbiota composition.
Yi Zhang +16 more
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Journal of Diabetes, Volume 14, Issue 10, Page 695-710, October 2022., 2022 Highlights Electroacupuncture (EA) regulates the intestinal flora by promoting intestinal motility. EA regulated the intestinal flora to reduce the level of systemic inflammation. EA lowering the blood glucose by the IKKβ/NF‐κB‐JNK‐IRS‐1‐AKT signal pathway.
Jing An +7 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 1983 肝脏的肿瘤以恶性为多,良性瘤甚少见。良性肿瘤中最常见的是肝脏海绵状血管瘤。1861年,Frerichs首先报告了该种疾患,1863年,Vichow详细描述了本病的形态。国内,胥氏在1956年首先报告1例,以后,陈士葆、吴孟超等分别报告了5例和32例的临床分析。 我院从1966年6月至1982年6月共收治肝脏海绵状血管瘤15例,现结合国内外文献加以分析、讨论,目的在于提高对此病的认识 ...
曹绣虎
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Journal of Diabetes, Volume 14, Issue 9, Page 606-619, September 2022., 2022 Highlights To what extent NAFLD is associated with glycemic remission among the general population remains unclear. The study elaborated that presence of NAFLD and fibrosis status decreased the chance of glycemic remission whereas NAFLD improvement mitigated glycemic deterioration, emphasizing joint management to liver‐focused subgroups of diabetes ...
Zhuojun Xin +15 more
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