Results 21 to 30 of about 1,710 (161)

Ceramide changes in abdominal subcutaneous and visceral adipose tissue among diabetic and nondiabetic patients 糖尿病和非糖尿病患者腹部皮下和内脏脂肪组织神经酰胺的变化

open access: yesJournal of Diabetes, Volume 14, Issue 4, Page 271-281, April 2022., 2022
Highlights The gender‐specific role of sphingolipids in obesity‐related metabolic dysfunctions is unclear. The aim of this study is to identify ceramide species by liquid chromatography‐mass spectrometry that accumulate in central fat in relation to status of diabetes and gender for subjects with a body mass index ≥40 kg/m2 or > 35 kg/m2 with ...
Michelle Brusatori   +7 more
wiley   +1 more source

MMC celebrating 6 years of experience and expansion 庆祝MMC六年的经验和壮大

open access: yes, 2022
Journal of Diabetes, Volume 14, Issue 5, Page 356-357, May 2022.
Itamar Raz
wiley   +1 more source

COVID‐19 and comorbidities: A role for dipeptidyl peptidase 4 (DPP4) in disease severity? 新冠肺炎与合并症:二肽基肽酶4在疾病严重程度中的作用?

open access: yesJournal of Diabetes, Volume 12, Issue 9, Page 649-658, September 2020., 2020
Highlights Coronavirus disease 2019 (COVID‐19) is caused by SARS‐CoV‐2; recent modeling of the structure of SARS‐CoV‐2 spike glycoprotein, which mediates viral‐host‐cell entry, predicts interactions with dipeptidyl peptidase 4 (DPP4) in addition to angiotensin‐converting enzyme 2.
Margaret F. Bassendine   +3 more
wiley   +1 more source

The Jiangnan diet, a healthy diet pattern for Chinese 江南饮食——一种健康的中国传统饮食模式

open access: yesJournal of Diabetes, Volume 12, Issue 5, Page 365-371, May 2020., 2020
Highlights To explore the localized “Mediterranean diet” for metabolic disorders prevention in China, we review the main healthy diet components, which the native inhabitants in the Yangtze River Delta region have eaten for a long time, and refer to this healthy diet as “Jiangnan Diet.” Abstract Geographically, the Qinling Mountain—Huai River line ...
Jiqiu Wang   +3 more
wiley   +1 more source

Renoprotective effects of brown adipose tissue activation in diabetic mice 棕色脂肪激活对糖尿病小鼠的肾脏保护作用

open access: yesJournal of Diabetes, Volume 11, Issue 12, Page 958-970, December 2019., 2019
Highlights This study demonstrates that of brown adipose tissue (BAT) with CL316,243 attenuates the progress of diabetic kidney disease (DKD). Mechanistically, the activation of BAT improved concentrations of circulating adipokines and microRNAs, which further affected the diabetic kidney and reactivated the AMP‐activated protein kinase/sirtuin 1 ...
Ying‐Ying Cai   +10 more
wiley   +1 more source

International clinical practice recommendations on the definition, diagnosis, assessment, intervention, and psychosocial aspects of developmental coordination disorder – Chinese (Mandarin) translation

open access: yesDevelopmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019
目的 本国际临床指南由欧洲残疾儿童学会(the European Academy of Childhood Disability,EACD)牵头制定,旨在解决发育性协调障碍(developmental coordination disorder,DCD)的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题,通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础,以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类,最终转化为指南建议。并由国际 ...
Jing Hua   +6 more
wiley   +1 more source

The relationship between the levels of white blood cell and lipopolysaccharide binding protein and intrahepatic triglyceride content , metabolic abnormalities in obese adults [PDF]

open access: yes, 2016
研究目的 非酒精性脂肪性肝病(NAFLD)常常伴随炎性因子的增多,且其发生发展与代谢综合征和胰岛素抵抗紧密相关。本研究针对中心性肥胖人群进行横断面数据分析,探讨白细胞(WBC)及脂多糖结合蛋白水平(LBP)与肝脏脂质含量(IHTC)及其相关代谢异常的关系。 研究方法 本研究纳入485名40-65岁中心性肥胖受试者,进行问卷调查包括病史、生活方式等;测定生化指标并进行胰岛功能评估;通过氢质子磁共振波谱(1H-MRS)技术定量分析肝内甘油三酯含量;进行内脏脂肪含量等测定 ...
孙倩
core  

The Functions and Mechanisms of Histone Demethylase JMJD1A in Urinary Bladder Cancer Development [PDF]

open access: yes, 2015
JMJD1A(JumonjiCdomain-containing1A),又名JHDM2A,KDM3A,是一种组蛋白去甲基化酶,可以特异性去除H3K9位点的一甲基化和二甲基化,在组蛋白甲基化修饰中起到重要作用。JMJD1A表达受到低氧诱导因子HIF-1α(hypoxia-induciblefactor1α)的调节,并且参与到肿瘤细胞对低氧环境的适应性调节过程中。 膀胱癌是世界范围内高发和高致死率的恶性肿瘤之一。已有报道JMJD1A在膀胱癌肿瘤组织中高表达,但是JMJD1A在膀胱癌的发生发展机制尚不清楚 ...
秦丽萍
core  

Research on the Development Path of Campus Soccer—by A Case Study of the Development of Campus Soccer in Four Levels Schools in Xiamen [PDF]

open access: yes, 2016
近年来,我国青少年身体素质不断下滑,患有肥胖症、近视眼的学生数量不断攀升。同时,由于中国足球的衰落,足球人口的不断减少,在“阳光体育”的基础上,经国家体育总局和教育部相关部门共同研究后,出台了《全国青少年校园足球活动实施方案》,标志着校园足球活动的正式启动。校园足球活动不仅是一项体育活动,更是一项育人工程。厦门市作为全国校园足球改革试验区,值得我们去探索校园足球发展的路径。 本文主要采取文献资料法、访谈法、问卷调查法、数理统计法、比较分析法,以厦门市20所大中小学校园足球发展现状为研究对象 ...
赵煜
core  

DOT1L and PAF1 synergistically regulate 3T3-L1 differentiation [PDF]

open access: yes, 2017
肥胖症是现代人类面临的很严重的健康问题,开发治疗肥胖症的方法有赖于对脂肪细胞分化机制的研究。DOT1L作为组蛋白H3的79位赖氨酸(H3K79)的唯一的甲基转移酶,其在MLL错误融合所引起的白血病发生过程中所起的作用早已受到研究人员的重视,以DOT1L为目标靶点的治疗白血病药物也在开发;与此同时DOT1L对于细胞分化所起的作用也逐渐受到人们的重视,对于其作用于细胞分化的机制,目前多数研究认为是其对H3K79的表观遗传修饰作用影响了分化相关的基因表达变化,从而调控了细胞分化进程 ...
彭国禹
core  

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