Results 31 to 40 of about 6,663 (174)
Ultrasound in Obstetrics &Gynecology, Volume 64, Issue 5, Page 635-650, November 2024.ABSTRACT Objectives To reach an international expert consensus on the diagnosis, prognosis and management of fetal lower urinary tract obstruction (LUTO) by means of a Delphi procedure, and to use this to define a core outcome set (COS). Methods A three‐round Delphi procedure was conducted among an international panel of experts in fetal LUTO.
H. J. Mustafa +90 more
wiley +1 more source
Renoprotective effects of brown adipose tissue activation in diabetic mice 棕色脂肪激活对糖尿病小鼠的肾脏保护作用
Journal of Diabetes, Volume 11, Issue 12, Page 958-970, December 2019., 2019 Highlights This study demonstrates that of brown adipose tissue (BAT) with CL316,243 attenuates the progress of diabetic kidney disease (DKD). Mechanistically, the activation of BAT improved concentrations of circulating adipokines and microRNAs, which further affected the diabetic kidney and reactivated the AMP‐activated protein kinase/sirtuin 1 ...
Ying‐Ying Cai +10 more
wiley +1 more source
The effect of pentosan polysulfate on diabetic nephropathy renal tubular epithelial cells injury through regulating p38 MAPK signaling pathway [PDF]
, 2016 目的：观察戊糖多硫酸钠是否通过调控P38MAPK干预糖尿病肾病肾小管上皮细胞的损伤。方法：利用不同浓度（10mmol/L～50mmol/L）葡萄糖刺激肾小管上皮细胞（HK-2）48h，应用CCK-8比色法检测肾小管上皮细胞增殖的改变。利用不同时间段（0h～48h）葡萄糖刺激细胞，用Westernblot法检测P38MAPK蛋白的表达水平。分为正常对照组（control组）、高糖组（HG组，葡萄糖30mmol/L)、戊糖多硫酸钠（PPS）组（PPS200µg/mL)、高糖＋戊糖多硫酸钠组（HG＋
张天英
core
Analysis of Renal Biopsy Pathology and Clinical Data With 710 Cases [PDF]
, 2017 目的 总结肾脏穿刺病理类型及临床表现之间的联系.方法 回顾性分析我院2008-2014年经皮肾脏穿刺活检的肾脏疾病患者的病理类型及临床表现.结果 临床表现以肾炎综合征（277例,占39.01%）及肾病综合征（265例,占37.32%）最为常见.肾炎综合征中最常见的病理类型是IgA肾病（154例,占55.60%）、系膜增生性肾小球肾炎（99例,占35.74%）.肾病综合征中最常见的病理类型是系膜增生性肾小球肾炎（92例,占34.72%）、原发性膜性肾病（80例,占30.19%）及肾小球微小病变（19例 ...
游雪叶, 钟山
core +1 more source
Ultrasound in Obstetrics &Gynecology, Volume 64, Issue 5, Page 661-668, November 2024.ABSTRACT Objective To determine the diagnostic accuracy of virtual autopsy using whole‐body postmortem ultra‐high field magnetic resonance imaging (MRI) at 7 Tesla (T), using a short T2‐weighted imaging (T2‐WI) protocol, compared with classical autopsy, for detecting structural abnormalities in small second‐trimester fetuses. Methods Thirty consecutive
A. Staicu +11 more
wiley +1 more source
Journal of Diabetes, Volume 11, Issue 12, Page 938-948, December 2019., 2019 Highlights Diabetic kidney disease is a common comorbidity of type 2 diabetes mellitus. In studies investigating the effect of renal function on the efficacy of treatment with glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), these agents improved glycemic control in patients with mild to moderately impaired kidney function, without significant ...
Lance A. Sloan
wiley +1 more source
The effect of nitric oxide on the basolateral 10 pS chloride channel activity in the TAL of the mouse kidney and its regulating mechanism [PDF]
, 2016 背景：小鼠肾脏髓袢升支粗段（TAL）可以通过管腔侧的2型钠钾二氯协同转运体（NKCC2）重吸收20-25%的NaCl，并通过管周膜侧的钠钾泵和Cl-通道排出，在尿浓缩机制中发挥着重要作用。有研究表明一氧化氮（NO）对TAL管腔膜侧NKCC2的活性有着显著的抑制作用，并减少TAL对Cl-的吸收。为了保持细胞的稳态平衡，如果管腔膜侧对Cl-的吸收减少了，那么管周膜侧的排出也应减少。电导为10pS的Cl-通道是管周膜侧TAL排出Cl-最重要的离子通道，因此我们推断其活性将受到NO的调控。 目的 ...
叶士伟
core
Calcitriol inhibits advanced glycation end product (AGE)-elicited mesangial cell damage by sequestrated RAGE-NF-κB Signaling [PDF]
, 2015 维生素D是通过与骨，甲状旁腺，肾脏和胃肠道的相互作用调节钙稳态，已经被用来作为糖尿病肾病（DKD）的常规用药。几个临床试验表明，维生素D在糖尿病肾病的治疗中，存在着减少蛋白尿和减缓肾损伤的抗炎作用，但其作用机制尚不清楚。而晚期糖化终产物（AGEs）在血浆和肾的积累，在糖尿病肾病中，是大家公认的促炎症分子。为了探索这种抗炎作用，我们设计实验。 研究目的：探寻骨化三醇减少AGEs引起的人肾系膜细胞炎症反应的机制，具体是探寻骨化三醇对AGEs引起的人系膜细胞表达白细胞介素-6（IL-6）和单核细胞趋化因子 ...
刘波
core
Transgenic overexpression of miR-466a significantly disturbs OREBP/NFAT5 renal expression and induces phenotypes that resemble diabetes insipidus in human [PDF]
, 2012 目的miR-466(a/b/c/e)-5p/3pmiRNAs是两组高度保守的miRNAs，其中-5p组间和-3p组间miRNAs的序列几乎完全一样。生物信息学分析和我们的前期研究显示，miR-466miRNAs可能可以在肾组织中对渗透应激调控转录因子OREBP/NFAT5进行转录后表达调控。我们因此希望研究miR-466a在转基因小鼠中的过表达对小鼠肾组织OREBP/NFAT5的表达和小鼠尿液浓缩机制的影响。 方法通过PCR从小鼠基因组中扩增miR-466a基因序列，将片段插入鸡 ...
刘颖
core
Protection Effect of Exogenous Fibroblast Growth Factor 21 on the Kidney Injury in Vascular Calcification Rats [PDF]
, 2018 Background: Chronic kidney disease (CKD) is closely related to the cardiovascular events in vascular calcification (VC). However, little has known about the characteristics of kidney injury caused by VC.
Cheng, Shu-Juan +8 more
core +3 more sources