Results 31 to 40 of about 7,900 (173)
Novel approaches to assess diet and kidney health risk [PDF]
, 2021 Chronic kidney disease (CKD) is a global public health problem. CKD is ultimately resulting in kidney failure and is an important cause of premature mortality and cardiovascular morbidity.
Cai, Qingqing
core +2 more sources
中西医结合护理Objective To explore the effect of family-centered empowerment model(FCEM)interventions on perceived stress, positive feelings and quality of life in primary caregivers of elderly patients with maintenance hemodialysis(MHD).
ZHANG Wei (张卫) +2 more
doaj +1 more source
Linchuang shenzangbing zazhi, 2021 系统性硬化症（systemic sclerosis,SSc）是一种以皮肤炎症、变性、增厚和纤维化进而硬化和萎缩为特征,同时伴有内脏器官受累的结缔组织病,可累及肺、肾脏、消化道、心脏等内脏器官。肾脏受累表现为肾病综合征（nephrotic syndrome,NS）的SSc国内外罕见,而肾脏病理检查结果为肾小球1型血小板反应蛋白7A域（thrombospondin type 1 domain-containing 7A,THSD7A）
Xue Hen, Huang Qiu-ping, Ma Xia
doaj
Zhongguo shiyan zhenduanxue, 2020 肾脏疾病是由多种原因导致的肾脏结构和功能不可逆性改变[1]。肾穿刺活检活是诊治肾脏疾病的关键环节,也是肾脏疾病明确诊断的"金标准"[2],但随着我国人口的老龄化、生活水平及生活环境变化,肾脏疾病谱可能有一定的变化。
华芳, 于艳波, 刘树军, 黄革
doaj
REGULATORY MECHANISMS OF NITRIC OXIDE ON THE BASOLATERAL CHLORIDE CHANNELS IN THE THICK ASCENDING LIBM OF KIDNEY [PDF]
, 2016 位于肾脏髓袢升支粗段（TAL）管周膜侧的氯通道在机体对Cl-的重吸收过程中发挥着十分关键的作用。本研究拟利用细胞贴附式膜片钳技术来观察一氧化氮（NO）是否通过抑制管周膜侧氯通道的活性来减少TAL对NaCl的重吸收以及这种抑制作用是否是通过环磷酸鸟苷（cGMP）依赖的蛋白激酶G（PKG）途径来实现的。实验结果表明，体外急性添加一氧化氮合酶（NOS）作用底物L-精氨酸以及NO外源性供体SNAP均能显著抑制TAL管周膜侧10-pS氯通道的活性。然而，存在NOS抑制剂或NO清除剂条件下，我们并未观察到L ...
吴鹏
core
World Medical &Health Policy, Volume 17, Issue 1, Page 129-148, March 2025.Abstract Patients with kidney failure need dialysis or a kidney transplant to survive. Living donor kidney transplantation (LDKT) is the best therapeutic option, yet global rates of LDKT have minimally increased, and there are disparities in access. The need for a systems approach to improvement has been highlighted.
Anna Horton +7 more
wiley +1 more source
Effects of Cinacalcet HCl on Secondary Hyperparathyroidism and Renal Injury in the Uremic Rat [PDF]
, 2016 目的 慢性肾脏病患者随着肾脏功能的逐渐减退，早期即可出现钙磷失衡、维生素D缺乏、甲状旁腺激素以及成纤维生长因子FGF23的升高，而这种矿物质代谢紊乱又可促使患者出现继发性甲状旁腺功能亢进以及加重肾脏损伤。目前CaSR激动剂作为有效抑制甲状旁腺增生的临床药物，适用于已发生SHPT的透析患者，为探究其是否也能防治继发性甲状旁腺亢进、矿物质代谢紊乱及肾脏损伤，本研究通过5/6肾大部切除术结合高磷饮食建立尿毒症大鼠模型，分别在造模成功早期预防性给予大鼠西那卡塞干预以及在大鼠慢性肾衰确立后给予盐酸西那卡塞干预 ...
孙青宜
core
Advanced Chinese Medicine, Volume 1, Issue 4, Page 200-209, December 2024.Abstract Psoriasis is a chronic, inflammatory skin condition characterized by its recurrent nature, often accompanied by various systemic comorbidities. It may not fully satisfy the precise diagnostic and therapeutic demands for psoriasis by the theory of syndrome differentiation and treatment of traditional Chinese medicine (TCM).
Jie Ma +8 more
wiley +1 more source
The effect of nitric oxide on the basolateral 10 pS chloride channel activity in the TAL of the mouse kidney and its regulating mechanism [PDF]
, 2016 背景：小鼠肾脏髓袢升支粗段（TAL）可以通过管腔侧的2型钠钾二氯协同转运体（NKCC2）重吸收20-25%的NaCl，并通过管周膜侧的钠钾泵和Cl-通道排出，在尿浓缩机制中发挥着重要作用。有研究表明一氧化氮（NO）对TAL管腔膜侧NKCC2的活性有着显著的抑制作用，并减少TAL对Cl-的吸收。为了保持细胞的稳态平衡，如果管腔膜侧对Cl-的吸收减少了，那么管周膜侧的排出也应减少。电导为10pS的Cl-通道是管周膜侧TAL排出Cl-最重要的离子通道，因此我们推断其活性将受到NO的调控。 目的 ...
叶士伟
core
Ultrasound in Obstetrics &Gynecology, Volume 64, Issue 5, Page 635-650, November 2024.ABSTRACT Objectives To reach an international expert consensus on the diagnosis, prognosis and management of fetal lower urinary tract obstruction (LUTO) by means of a Delphi procedure, and to use this to define a core outcome set (COS). Methods A three‐round Delphi procedure was conducted among an international panel of experts in fetal LUTO.
H. J. Mustafa +90 more
wiley +1 more source