Results 11 to 20 of about 1,469,004 (206)
A Review of micro RNAs changes in T2DM in animals and humans miRNAs在2型糖尿病人类和动物中的变化
Journal of Diabetes, Volume 15, Issue 8, Page 649-664, August 2023., 2023 Highlights MicroRNAs (miRNAs) are overexpressed in inflammation, insulin resistance, and type 2 diabetes mellitus (T2DM). Many types of miRNAs are changed during the T2DM progression. miRNAs have a potential role as a biomarker in T2DM diagnosis. Abstract Type 2 diabetes mellitus (T2DM) and its associated complications have become a crucial public ...
Mohammad Reza Afsharmanesh +3 more
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Journal of Diabetes, Volume 15, Issue 7, Page 607-621, July 2023., 2023 Highlights The CD4 T cells of type 1 diabetes (T1D) patients particularly having HLA‐DRB1*03‐DQA1*05‐DQB1*02 haplotype are reactive against a particular region of the glutamic acid decarboxylase (GAD65) protein. GAD65 peptides encompassing 288–308 amino acid positions (peptide pool 2) may be favored by the HLA‐DR3 molecule for presentation to CD4 T ...
Neihenuo Chuzho +7 more
wiley +1 more source
Journal of Diabetes, Volume 14, Issue 3, Page 192-204, March 2022., 2022 Highlights Many proinflammatory cytokines could be decreased after 1 week of intensive insulin therapy using continuous subcutaneous insulin infusion (CSII). This was the first report showing that the cytokines of interleukin‐6 receptor (IL‐6R), tissue inhibitor of metalloproteinase‐2 (TIMP‐2), platelet‐derived growth factor type BB (PDGF‐BB), and ...
Junyu He +6 more
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Veterinary Dermatology, Volume 31, Issue 2, Page 154-e30, April 2020., 2020 Background Thymic stromal lymphopoietin (TSLP) plays a key role in the development of allergic inflammation. Little is known about possible triggers of equine TSLP expression. Hypothesis To investigate TSLP expression in equine insect bite hypersensitivity (IBH) skin lesions.
Iva Cvitas +4 more
wiley +1 more source
The role of Rip3-mediated necrosis in system inflammatory response syndrome [PDF]
, 2016 肿瘤坏死因子-α可以诱导小鼠发生全身免疫反应综合征，其过程中发生了各组织器官的坏死和一系列级联免疫反应。在肿瘤坏死因子-α的作用下，组织细胞中的受体相互作用蛋白3被激活并募集坏死小体，导致细胞坏死，引起周围组织的炎症反应。同时，肿瘤坏死因子-α本身作为促炎因子扩大了机体免疫反应的范围。在肿瘤坏死因子-α诱导的全身免疫反应综合征中，盲肠首先表现出损伤，并且这种损伤可以被Rip3基因敲除所抑制。本论文通过建立小鼠盲肠切除术模型，与肿瘤坏死因子-α诱导全身免疫反应综合征模型并用 ...
李旸欣
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The Molecular Mechanism of Honokiol Inhibits TNFα /Nur77 Survival Pathway [PDF]
, 2012 在许多肿瘤组织中，肿瘤坏死因子α能够促进肿瘤细胞生存和增殖。通常，在肿瘤微环境中肿瘤坏死因子α的主要来源是多种定向分化的巨噬细胞，而肿瘤坏死因子α可以激活NF-κB以及MAPK等信号通路促进肿瘤细胞的生存。本文研究核受体Nur77在肿瘤坏死因子α相关的生存通路中的作用及和厚朴酚通过下调核受体Nur77蛋白水平抑制肿瘤坏死因子α介导的生存通路。 依据天然产物和厚朴酚治疗各种疾病的多效性，抑制肿瘤细胞增殖的高效性及治疗癌症的临床数据 ...
谢雷
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健康小鼠进食绣球菌对腹腔巨噬细胞分泌肿瘤坏死因子α的影响 [PDF]
, 2018 测定健康小鼠进食绣球菌对腹腔巨噬细胞分泌肿瘤坏死因子α(TNF-α)的影响.SPF级Balb/C健康小鼠分组进食普通饲料、分别含绣球菌饲料、干品、浸汁饮水或其添加物组合、分别含酵母β-葡聚糖饲料、浸汁饮水或其添加物组合;进食一定时间后,分离腹腔巨噬细胞,使用含质量分数10%胎牛血清的RPMI1640培养液培养,TNF-α试剂盒检测上清液中的TNF-α质量浓度.结果表明,强化进食绣球菌组合(绣球菌饲料+干品+浸汁)的小鼠与对照组或酵母β-葡聚糖组合(酵母β-葡聚糖饲料+浸汁)小鼠相比,体质量不升反降 ...
张鸣青 +6 more
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, 2019 【目的】探讨椎旁注射臭氧对SD大鼠盘源性疼痛模型的镇痛规律，对椎间盘退变的影响，并初步探讨其镇痛作用机制。【方法】65只雄性SD大鼠随机分为对照组、模型组和臭氧组。模型组和臭氧组大鼠经皮穿刺L5-6椎间盘全层纤维环制作SD大鼠盘源性疼痛模型，臭氧组在造模后第22天椎旁注射25mg/L臭氧1mL，对照组大鼠不作处理。手术前后各时间点使用定量痛觉敏感评估技术和磁共振检查实验动物的50%机械撤足阈值（50%MWT）和椎间盘Pfirrmann分级，并使用western ...
吴志强
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Experimental Study on the Effects of Ciji Hua’Ai BaoSheng Decoction on Cytokines of Tumor Chemotherapy Model Mouse with H22 Hepatoma Carcinoma Cells [PDF]
, 2015 背景：癌症是一类严重危害人类生命健康的致死性疾病。化疗(Chemotherapy)是癌症临床治疗的经典方法之一，但化疗药物无选择性杀伤肿瘤细胞的同时，也杀伤正常细胞，带来较严重的副作用，严重影响患者生存质量及预后。慈济化癌保生汤(CHBF)是导师王彦晖教授临床多年诊治癌症所创立的经验方，该方用于癌症患者化疗后的长期调理，具有提高生存质量，改善体质、降低复发率及延长生存期的作用。前期研究证实[1]：慈济化癌保生颗粒能延长移植瘤和腹水瘤化疗模型小鼠的生存期，有一定的抑制化疗后移植瘤生长的作用 ...
GUAN JIE LOY
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Effect of Acupuncture as an Adjuvant Therapy for Intravenous Thrombolytic Treatment on Peripheral Inflammatory Factors and Neurologic Function in Patients with Acute Ischemic Stroke [PDF]
, 2022 BackgroundAcupuncture has proved effective in reducing inflammatory cytokine levels. However, it is still unclear about its improvement on the neurologic function and activities of daily living as well as over all clinical efficacy in patients with acute
CHEN An, CAO Xiao, ZHANG Huilin, LIAN Jianfeng
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