Results 11 to 20 of about 4,316 (103)
A Review of micro RNAs changes in T2DM in animals and humans miRNAs在2型糖尿病人类和动物中的变化
Journal of Diabetes, Volume 15, Issue 8, Page 649-664, August 2023., 2023 Highlights MicroRNAs (miRNAs) are overexpressed in inflammation, insulin resistance, and type 2 diabetes mellitus (T2DM). Many types of miRNAs are changed during the T2DM progression. miRNAs have a potential role as a biomarker in T2DM diagnosis. Abstract Type 2 diabetes mellitus (T2DM) and its associated complications have become a crucial public ...
Mohammad Reza Afsharmanesh +3 more
wiley +1 more source
Journal of Diabetes, Volume 15, Issue 7, Page 607-621, July 2023., 2023 Highlights The CD4 T cells of type 1 diabetes (T1D) patients particularly having HLA‐DRB1*03‐DQA1*05‐DQB1*02 haplotype are reactive against a particular region of the glutamic acid decarboxylase (GAD65) protein. GAD65 peptides encompassing 288–308 amino acid positions (peptide pool 2) may be favored by the HLA‐DR3 molecule for presentation to CD4 T ...
Neihenuo Chuzho +7 more
wiley +1 more source
Journal of Diabetes, Volume 14, Issue 3, Page 192-204, March 2022., 2022 Highlights Many proinflammatory cytokines could be decreased after 1 week of intensive insulin therapy using continuous subcutaneous insulin infusion (CSII). This was the first report showing that the cytokines of interleukin‐6 receptor (IL‐6R), tissue inhibitor of metalloproteinase‐2 (TIMP‐2), platelet‐derived growth factor type BB (PDGF‐BB), and ...
Junyu He +6 more
wiley +1 more source
Veterinary Dermatology, Volume 31, Issue 2, Page 154-e30, April 2020., 2020 Background Thymic stromal lymphopoietin (TSLP) plays a key role in the development of allergic inflammation. Little is known about possible triggers of equine TSLP expression. Hypothesis To investigate TSLP expression in equine insect bite hypersensitivity (IBH) skin lesions.
Iva Cvitas +4 more
wiley +1 more source
Torch感染与自然流产及Th1/Th2细胞因子水平相关分析
Zhongguo shiyan zhenduanxue, 2021 为探讨TORCH病原体感染与自然流产及Th1/Th2细胞因子水平的相关性,本研究对沧州中西医结合医院215例自然流产孕妇和100例正常妊娠孕妇TORCH病原体感染情况进行分析,并比较TORCH感染孕妇和未感染正常妊娠孕妇血清中Th1细胞分泌的肿瘤坏死因子-α(TNF-α)和Th2细胞分泌的白细胞介素-4(IL-4)水平,现报道如下。
褚娜利 +4 more
doaj
肿瘤坏死因子相关凋亡诱导配体联合化疗药物对非小细胞肺癌细胞的作用机制研究
Zhongguo shiyan zhenduanxue, 2011 肿瘤坏死因子相关凋亡诱导配体（tumor necrosis factor related apoptosis-inducing ligand,TRAIL）在肿瘤的免疫监视中起到一定作用。rhTRAIL可诱导肿瘤细胞凋亡。研究表明,大多数非小细胞肺癌细胞株对TRAIL抵抗,因此,我们研究化疗药物与TRAIL联合作用对非小细胞肺癌细胞的作用机制 ...
王爽 +4 more
doaj
联合检测炎症因子IL-6、TNF-α和MCP-1对冠心病临床诊断价值
Zhongguo shiyan zhenduanxue, 2012 冠状动脉粥样硬化性心脏病指冠状动脉粥样硬化使血管腔狭窄或阻塞,或（和）因冠状动脉功能性改变（痉挛）导致心肌缺血缺氧或坏死而引起的心脏病。"炎症假说"是动脉粥样硬化主要发病机制[1],白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和单核细胞趋化因子-1（MCP-1）等炎症性因子在其过程中发挥着重要的作用 ...
黄山 +5 more
doaj
Zhongguo shiyan zhenduanxue, 2018 卵巢恶性肿瘤致死率居于妇科恶性肿瘤首位[1],由此人们对于卵巢癌的防治日益重视。TNF相关凋亡诱导配体即TRAIL属于肿瘤坏死因子TNF之一,能够有所针对性地促进肿瘤细胞凋亡,并且不会对健康组织造成明显的副作用[2]。山奈酚是一种具有抗癌、增强抗癌治疗效果等多种生物功能的黄酮类化合物[3]。卵巢恶性肿瘤以手术及化疗为主的辅助治疗为原则[1 ...
简文文 +6 more
doaj
Zhongguo shiyan zhenduanxue, 2019 中国是肺癌高发国家,每年新增患者73.3万,死亡人数达到61.0万,肺癌已经成为中国恶性肿瘤中的第一杀手[1]。相比于传统的检测方法,利用二代测序技术对肺癌进行基因层面的突变检测,已在疾病早筛、靶向治疗、复发监测等领域体现出强大的优势。循环肿瘤DNA来自于凋亡或者坏死的肿瘤细胞,在很大程度上可以反映肿瘤的分子特征 ...
尤涛 +5 more
doaj
Zhongguo shiyan zhenduanxue, 2011 牙周炎时,各类细胞因子形成网络调控着疾病的发生发展,在宿主反应过程中,一系列的炎症介质,特别是众多的细胞因子起到了至关重要的作用,包括白细胞介素1（IL-1）、白细胞介素6（IL-6）、白细胞介素8（IL-8）、肿瘤坏死因子（TNF ...
杨欢, 王晓峰, 张天夫
doaj