Results 11 to 20 of about 8,999 (156)

Canine melanocytes: Immunohistochemical expression of melanocytic markers in different somatic areas

Veterinary Dermatology, Volume 34, Issue 4, Page 284-297, August 2023., 2023
Background – Melanoblasts originate in the neural crest from where they migrate to peripheral tissues and differentiate into melanocytes. Alteration during melanocyte development and life can cause different diseases, ranging from pigmentary disorders and decreased visual and auditory functions, to tumours such as melanoma.
Ilaria Porcellato, Margherita Orlandi, Adriana Lo Giudice, Monica Sforna, Luca Mechelli, Chiara Brachelente   +5 more
wiley   +1 more source

Longer leukocyte telomere length increases cardiovascular mortality in type 2 diabetes patients 白细胞端粒长度增长会增加2型糖尿病患者的心血管死亡率

Journal of Diabetes, Volume 15, Issue 4, Page 325-331, April 2023., 2023
Highlights Leukocyte telomere length was independently associated with the risk of cardiovascular mortality. Leukocyte telomere length was not associated with the risk of all‐cause mortality in patients with diabetes. Telomere length may be a predictor of cardiovascular mortality in diabetes.
Ziwei Chen, Yao Shen, Jing He, Yang Shen, Weida Zhu, Xiaohui Wu, Mingbing Xiao   +6 more
wiley   +1 more source

Effect of type 2 diabetes on A disintegrin and metalloprotease 10 2型糖尿病对解整合素金属蛋白酶10表达的影响

Journal of Diabetes, Volume 14, Issue 6, Page 394-400, June 2022., 2022
Highlights a disintegrin and metalloprotease 10 (ADAM10), a sheddase responsible for the cleavage of a variety of cell surface molecules, has been implicated in the pathogenesis of Alzheimer disease, atherosclerosis, and inflammatory and neoplastic disorders, and systemic ADAM10 concentration may potentially be used as a prognostic biomarker. Our study
Sum Lam, Sammy Wing‐Ming Shiu, Ying Wong, Kathryn Choon‐Beng Tan   +3 more
wiley   +1 more source

Serum concentrations of IL‐31 in dogs with nonpruritic mast cell tumours or lymphoma

Veterinary Dermatology, Volume 31, Issue 6, Page 466-e124, December 2020., 2020
Background The aim of this study was to compare serum interleukin (IL)‐31 concentrations in dogs with lymphoma and mast cell tumours (MCT) without pruritus to those of healthy dogs. Hypothesis/Objectives To determine if IL‐31 plays a role in tumour pathogenesis and if IL‐31 could be a biological marker for disease progression.
Nataliia Ignatenko, Andrea J. Gonzales, James E. Messamore, Johannes Hirschberger, Laura Udraite‐Vovk, Teresa M.S.A. Boehm, Karin Troedson, Csilla Fejos, Ralf S. Mueller   +8 more
wiley   +1 more source

Insulin resistance is associated with urinary albumin‐creatinine ratio in normal weight individuals with hypertension and diabetes: The REACTION study 胰岛素抵抗与尿白蛋白肌酐比值在体重指数正常的高血压合并糖尿病人群中相关:中国REACTION研究

Journal of Diabetes, Volume 12, Issue 5, Page 406-416, May 2020., 2020
Highlights In patients with hypertension and diabetes, early detection and intervention of insulin resistance and related risk factors in patients with normal BMI may reduce the occurrence of urinary microalbumin and delay the progression of CKD. Abstract Background The relationship between albuminuria and insulin resistance (IR) has not been clarified
Shi Gu, Anping Wang, Guang Ning, Linxi Zhang, Yiming Mu   +4 more
wiley   +1 more source

Dual Checkpoint Inhibition with Ipilimumab plus Nivolumab After Progression on Sequential PD‐1/PDL‐1 Inhibitors Pembrolizumab and Atezolizumab in a Patient with Lynch Syndrome, Metastatic Colon, and Localized Urothelial Cancer

The Oncologist, Volume 24, Issue 11, Page 1416-1419, November 2019., 2019
Abstract Immune checkpoint blockade (ICB) is an approved therapy for advanced metastatic mismatch repair (MMR)‐deficient cancer regardless of tissue of origin. Although therapy is effective initially, recurrence rates are significant, and long‐term outcomes remain poor for most patients.
Arthur Winer, Pooja Ghatalia, Nicole Bubes, Fern Anari, Asya Varshavsky, Vineela Kasireddy, Yang Liu, Wafik S. El‐Deiry   +7 more
wiley   +1 more source

Incorporating MicroRNA into Molecular Phenotypes of Circulating Tumor Cells Enhances the Prognostic Accuracy for Patients with Metastatic Breast Cancer

The Oncologist, Volume 24, Issue 11, Page e1044-e1054, November 2019., 2019
Abstract Background The molecular phenotype of circulating tumor cells (CTCs) was associated with clinical outcome of patients with breast cancer. CTCs isolated from patients with metastatic breast cancer (MBC) display a unique microRNA (miRNA) expression profile.
Weige Tan, Gehao Liang, Xinhua Xie, Wenguo Jiang, Luyuan Tan, Andrew J. Sanders, Zihao Liu, Yun Ling, Wenjing Zhong, Zhenluan Tian, Wanyi Lin, Chang Gong   +11 more
wiley   +1 more source

International clinical practice recommendations on the definition, diagnosis, assessment, intervention, and psychosocial aspects of developmental coordination disorder – Chinese (Mandarin) translation

Developmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019
目的 本国际临床指南由欧洲残疾儿童学会（the European Academy of Childhood Disability，EACD）牵头制定，旨在解决发育性协调障碍（developmental coordination disorder，DCD）的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题，通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础，以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类，最终转化为指南建议。并由国际 ...
Jing Hua, Wenchong Du, Xiaotian Dai, Meiqin Wu, Xianying Cai, Min Shen, Liping Zhu   +6 more
wiley   +1 more source

The Role and Mechanism of RARα in the Development of Gastric Carcinoma [PDF]

, 2016
尽管胃癌的发病率在下降，但其死亡率仍位于全球第二位。由于缺乏有效的早期诊断方法，大多数胃癌病人在确诊时已到了晚期阶段。因此亟需寻找新的胃癌诊断与治疗的分子靶点。许多研究表明视黄酸受体在肿瘤的进程中起着重要的作用，然而，RARα与肿瘤的关系尚不清楚。本论文以胃癌为研究对象，阐明RARα在胃癌发生发展中的作用及其分子机制。 本论文主要通过Q-PCR、Westernblot、IHC/ICC等方法研究胃癌组织和细胞中RARα的表达情况及其临床意义。利用MTT、细胞集落形成、裸鼠皮下异种成瘤、流式细胞术 ...
任红岳
core  

The application of 18F-FDG PET/CT with tumor markers NSE and ProGRP in the diagnosis and treatment of small cell lung cancer [PDF]

Small cell lung cancer (SCLC) is the most common neuroendocrine tumor in the lungs. SCLC is characterized by high malignancy and high recurrence and metastasis rates.
LIN Shuai, WANG Yanli
core   +1 more source