Results 21 to 30 of about 8,344 (191)
Journal of Diabetes, Volume 12, Issue 5, Page 406-416, May 2020., 2020 Highlights In patients with hypertension and diabetes, early detection and intervention of insulin resistance and related risk factors in patients with normal BMI may reduce the occurrence of urinary microalbumin and delay the progression of CKD. Abstract Background The relationship between albuminuria and insulin resistance (IR) has not been clarified
Shi Gu +4 more
wiley +1 more source
Test and Significance of CEA, NSE, CA125, CYFRA21-1 in Lung Cancer [PDF]
, 2017 目的 探讨CEA、NSE、CA125、CYFRA21-1在肺癌中的检测及意义.方法 回顾性分析2015年10月—2016年12月医院收治的肺部疾病患者166例,其中89例肺癌患者设为肺癌组,其余77例肺部良性病变患者设为肺部良性病变组.另选择35名健康志愿者作为健康对照组,电化学发光法检测3组血清中CEA、NSE、CA125、CYFRA21-1含量,分析单项及联合检测对肺癌的诊断价值.结果 肺癌组患者血清CEA、NSE、CA125、CYFRA21-1分别为（4.32±0.83）ng/mL、（11.54 ...
何佳瑜, 何正, 罗世翊, 魏玲
core +1 more source
Analysis of tumor-related features of non-small cell lung cancer based on TCR repertoire workflow [PDF]
, 2023 Objective·To explore the immune-related characteristics of non-small cell lung cancer (NSCLC), discover potential tumor markers in V-J genes, and lay the foundation for establishing a TCR-antigen recognition prediction model.Methods·A total of 704 NSCLC ...
LIU Zhenhao +5 more
core +1 more source
The Oncologist, Volume 24, Issue 11, Page 1416-1419, November 2019., 2019 Abstract Immune checkpoint blockade (ICB) is an approved therapy for advanced metastatic mismatch repair (MMR)‐deficient cancer regardless of tissue of origin. Although therapy is effective initially, recurrence rates are significant, and long‐term outcomes remain poor for most patients.
Arthur Winer +7 more
wiley +1 more source
The Oncologist, Volume 24, Issue 11, Page e1044-e1054, November 2019., 2019 Abstract Background The molecular phenotype of circulating tumor cells (CTCs) was associated with clinical outcome of patients with breast cancer. CTCs isolated from patients with metastatic breast cancer (MBC) display a unique microRNA (miRNA) expression profile.
Weige Tan +11 more
wiley +1 more source
Developmental Medicine &Child Neurology, Volume 61, Issue 3, Page E1-E35, March 2019., 2019 目的 本国际临床指南由欧洲残疾儿童学会（the European Academy of Childhood Disability，EACD）牵头制定，旨在解决发育性协调障碍（developmental coordination disorder，DCD）的定义、诊断、评估、干预以及与社会心理方面的临床应用关键问题。 方法 本指南针对五个领域的关键问题，通过文献综述和专家团队的正式讨论达成共识。为保证指南的循证基础，以“机制”、“评估”和“干预”为检索词, 对2012年更新以来提出的最新建议以及新增的“社会心理问题”和“青少年/成人”为检索词进行检索。根据牛津大学循证医学中心证据等级 (证据水平 [level of evidence, LOE]1–4) 将结果进行分类，最终转化为指南建议。并由国际 ...
Jing Hua +6 more
wiley +1 more source
Diagnostic value of cell-free DNA to biliary tract cancers: a meta-analysis [PDF]
, 2023 Objective·To comprehensively evaluate the diagnostic accuracy of cell-free DNA (cfDNA) to biliary tract cancer (BTC), and provide a basis for better clinical application.Methods·Clinical studies on the diagnostic value of cfDNA to BTC were collected by ...
GONG Wei +5 more
core +1 more source
Establishment and Diagnostic Application of Monoclonal Antibodies against Tumor Markers HE4 and CA19-9 [PDF]
, 2017 恶性肿瘤严重威胁人类健康，早期肿瘤的治疗预后显著优于晚期肿瘤。检测血清肿瘤标志物是肿瘤早期筛查的一种有效方式，通过检测血清中肿瘤标志物的存在或量变可以反映体内肿瘤的发生和发展程度，在肿瘤的诊断、分类、分期、监测、预后及指导治疗中发挥重要作用。目前，我国的肿瘤标志物诊断试剂及其诊断试剂研发所需的抗原和抗体原料基本依赖进口，供货受制于人和价格昂贵等因素严重制约了我国肿瘤标志物早期筛查的推广普及。因此，研制国产化肿瘤标志物抗原和抗体，并建立相应的肿瘤标志物诊断试剂显得十分必要 ...
王英雪
core
Potential Diagnosis and Prognosis Value of Plasma MicroRNA-19a in Esophageal Cancer [PDF]
, 2015 背景：食管癌是发生于食管上皮组织的恶性肿瘤，具有高死亡率、高复发率和高转移率的特点。然而目前针对食管癌敏感的肿瘤标志物不多，且诊断效率较低，远远不能满足临床需求。MicroRNA是一类非编码RNA，可以稳定存在于人体血浆中并且易于检测。据报道，microRNA在诸多疾病状态下会出现表达异常，如食管癌、结直肠癌、肝癌等，这一发现极大地增加了血浆microRNA作为食管癌标志物的可能。在前期实验中，我们观察到microRNA-19a（miR-19a）在食管癌血浆标本中高表达，本文将重点探讨miR ...
白永颖
core
肾透明细胞癌患者术前血浆GAPDH cfNA水平对诊断及预后的价值
Zhongguo shiyan zhenduanxue, 2021 肾透明细胞癌（ccRCC）是最常见的肾恶性肿瘤[1],但由于缺乏特异性的生物标志物,目前临床上对于ccRCC预后的判断仍然依赖患者或肿瘤的临床和病理特征。寻找一种有效的生物标志物对于ccRCC患者的术后检测以及管理至关重要[2]。循环肿瘤细胞（CTCs）已经被证明在肾细胞癌患者的早期诊断和预后中具有潜在的应用价值[3-4]。
邱实, 陈坤, 衣琳, 于越海
doaj