Results 21 to 30 of about 3,411 (120)
The research of the detection of thalassaemia multiple mutations by next-generation sequencing technology [PDF]
, 2015 地中海贫血又称珠蛋白生成障碍性贫血，早期的病例来自地中海地区，故称为地中海贫血，是世界范围内影响最大的单基因病之一，遵循孟德尔遗传定律。该病是由珠蛋白基因的缺失或点突变所致，根据其变异的肽链可分为α地贫和β地贫。由于其基因缺陷的复杂、多样，使缺乏的珠蛋白链类型、数量、临床症状变异较大。临床上对中、重度地中海贫血无行之有效的治疗方法，给社会、家庭、个人带来了沉重的经济及精神负担。故有效检出地中海贫血患者、进行婚前孕前指导、产前诊断、避免地中海贫血患儿的出生，有着极其重要的社会意义 ...
成明
core
Ultrasound in Obstetrics &Gynecology, Volume 66, Issue 5, Page 582-588, November 2025.ABSTRACT Objective The corpus callosum (CC) is an interhemispheric structure that facilitates communication between the two cerebral hemispheres. Anomalies of the CC are frequent and associated with a wide spectrum of altered neurodevelopmental outcomes.
R. Corroenne +55 more
wiley +1 more source
A Study on Roles of Slit2 in Hepatocellular Carcinoma Cells [PDF]
, 2015 Slit家族蛋白是一种进化上高度保守的细胞外分泌糖蛋白。对Slit的研究最初的重点是它在神经生长的作用，Slit作为配体通过与跨膜受体Roundabout(Robo)结合在中枢神经系统轴突导向中起到重要的作用。近些年的研究发现Slits与Robos在一些肿瘤中异常表达，说明Slit/Robo信号在肿瘤的发生发展过程中起到重要的作用。 Oncomine数据库的检索结果显示，与正常组织相比，肝细胞癌中受体Robo1的表达量有显著的增加，而Slit2的表达量则有一定的差别，多数情况下表现为下调 ...
朱韦林
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Ultrasound in Obstetrics &Gynecology, Volume 66, Issue 5, Page 621-630, November 2025.ABSTRACT Objectives To compare the maternal hemodynamics of Chinese women at low and at high risk for preterm pre‐eclampsia (PE) and assess the differences in hemodynamic parameters between high‐risk women with or without prophylactic aspirin. Methods This was a prospective longitudinal case–control study of 857 Chinese women with a singleton pregnancy
X. Wang +11 more
wiley +1 more source
Generation and Characterization of HCMV Specific Human Antibody to Explore Antibody Response Profile in HCMV Naturally Infected Individuals [PDF]
, 2015 人巨细胞病毒（Humancytomegalovirus，HCMV）是一种常见的疱疹病毒，在人群中普遍感染，儿童感染率约为10%-40%，成人为50%-90%，大部分感染者为无临床症状的健康人。但机体免疫功能低下的人群如器官移植患者及AIDS病人，更易发生HCMV病毒的新发或复发感染，引起致命疾病如肺炎、肝炎、脑炎等，从而导致器官移植失败及术后死亡；同时HCMV病毒也是宫内感染中危害最大的病毒之一，感染率占怀孕妇女的0.5%-2%，尤其是在发展中国家较为常见，孕妇感染后自身多无明显症状或轻微症状 ...
夏琳
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Ultrasound in Obstetrics &Gynecology, Volume 66, Issue 4, Page 433-442, October 2025.ABSTRACT Objective Currently, there are several surgical approaches to manage fetal open spina bifida (OSB), namely postnatal surgical repair, open fetal surgery and its minimally invasive alternative, fetoscopic repair. Our objective was to determine the optimal surgical approach for OSB, weighing the benefits and risks to the fetus and the pregnant ...
Y. Kunpalin +6 more
wiley +1 more source
Impact of race‐based customization on detection of fetal growth restriction
Ultrasound in Obstetrics &Gynecology, Volume 66, Issue 4, Page 480-485, October 2025.ABSTRACT Objective Fetal growth standards determine which fetuses are diagnosed with fetal growth restriction (FGR) and become candidates for enhanced fetal monitoring. Given the existence of race‐based differences in fetal and neonatal weights, we sought to determine the impact of race‐based customization of fetal growth curves on the antenatal ...
P. Ramesh, L. Lemon, J. C. Larkin
wiley +1 more source
An ultra-thin amniotic membrane preparation and its application as carrier in corneal epithelium tissue-engineering [PDF]
, 2016 目的：羊膜是目前应用最广泛的构建组织工程角膜上皮的载体。但在临床应用中发现，基于羊膜构建的组织工程角膜上皮在移植术后角膜的透明度恢复并不理想。目前认为，羊膜基质的纤维细胞层及疏松的海绵层可能是影响羊膜透明度的主要原因。因此，本研究对传统去上皮羊膜（DAM）进行改造，制备一种新型的超薄羊膜（UAM）载体，并评估其生物学及光学性质，同时探讨使用该种载体构建组织工程角膜上皮的可行性。 方法：本研究利用0.02%的EDTA去除失活羊膜组织的上皮细胞，并采用IV型胶原酶消化去除羊膜基质的纤维层及海绵层 ...
张丽颖
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Clinical Observation of Different Regimens for Treatment Early Onset Preeclampsia [PDF]
, 2017 目的比较不同方案治疗早发型子痫前期的疗效和安全性。方法选取2013年5月至2016年10月在我院妇产科诊治的早发型子痫前期孕妇200例,根据随机数字表法分成4组,每组各50例:硫酸镁常规治疗组(A组);硫酸镁常规治疗+丹参注射液组(B组);硫酸镁常规治疗+低分子肝素组(C组);硫酸镁常规治疗+丹参注射液+低分子肝素组(D组)。观察各组脐动脉收缩压与舒张压比值(S/D)、平均动脉压、24h蛋白尿、分娩方式、延长孕龄时间、新生儿窒息率、母体并发症和不良反应等指标。结果①各组治疗后平均动脉压均显著降低 ...
宋润珞 +5 more
core +1 more source
Infant Mental Health Journal: Infancy and Early Childhood, Volume 46, Issue 5, Page 549-563, September 2025.Abstract This quasi‐experimental study examined the effect of a virtual supportive program on knowledge among mothers of preterm infants and their bond. Mothers of preterm infants are at risk of becoming emotionally detached from their infants because of immediate separation and the lack of support during the early postpartum period, especially in ...
Supaporn Pusri +2 more
wiley +1 more source