Results 31 to 40 of about 1,473 (163)
, 2018 目的探讨双胎早产与单胎早产高危因素的特点以及单、双胎早产儿的结局。方法回顾性分析广州医科大学附属第三医院2009年1月至2015年12月的单、双胎孕产妇与新生儿临床数据资料。结果研究期间在该院分娩的36 931例新生儿,双胎2080例,单胎34 851例,其中早产5877例,双胎早产1395例(双胎早产组),早产率为67.07%;单胎早产4482例(单胎早产组),单胎早产率为12.86%,总计早产发生率为15.91%,双胎早产率明显高于单胎,差异有统计学意义(P22~26岁组、>26~30岁组、>30 ...
余波澜 +7 more
core +1 more source
Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 4, Page 470-477, April 2025.ABSTRACT Objective To evaluate the presence and levels of cytomegalovirus (CMV) cell‐free DNA (cfDNA) fragments in women pregnant with a fetus with symptomatic congenital CMV (cCMV). Methods The study comprised nine women whose fetuses were diagnosed with cCMV between June 2019 and July 2024 at 20 + 4 to 34 + 1 weeks' gestation (n = 8) or neonatally (n
B. H. W. Faas +9 more
wiley +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2002 【目的】通过了解胎盘病理变化与胎儿感染HBV 的关系, 探讨胎儿感染的机理。【方法】测量160 例足月妊娠 孕妇胎盘大小、质量、脐长, 并进行大体病理学检查。分组包括30 例胎儿感染组、胎儿血指标阴性者80 例为阴性对照组、正常 孕妇50 例为正常组。对其中61 例HBV 携带者孕妇胎盘进行详细的组织病理学观察(包括胎儿感染组28 例及对照组33 例), 分级诊断分析, 用PCR、ELISA 法检测胎儿血HBV DNA 和HBsAg 。【结果】①胎儿感染组平均胎盘体积为(638 ±179 ...
刘颖琳, 刘新质
doaj
Curcumin inhibit VEGF expression via IGF-1R pathway in hypoxic-induced HepG2 human hepatocellular carcinoma cells [PDF]
, 2016 肝细胞性肝癌（hepatocellularcarcinoma,HCC），是世界上最常见的恶性肿瘤之一，具有高度恶性、血供丰富、生长迅速及起病相对隐匿等特点。作为富血管实体瘤，HCC的主要特征是肿瘤细胞失控性增殖导致肿瘤内缺氧微环境的形成，促进新生血管生成，从而促进肿瘤生长。 姜黄素是从草本姜科植物姜黄的根茎中提取出来的一种脂溶性酚类色素，具有抗氧化、抗炎、抗凝、降脂、抗动脉粥样硬化、抗肿瘤、抗血管生成、保护肝功能及抗衰老消除自由基等广泛药理作用。姜黄素具有抗癌谱广、毒副作用小及价格低廉的优点 ...
陈艺辉
core
Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 4, Page 447-455, April 2025.ABSTRACT Objective A soluble fms‐like tyrosine kinase‐1 (sFlt‐1)‐to‐placental growth factor (PlGF) ratio cut‐off of 38 is currently considered optimal for ruling out pre‐eclampsia (PE); however, implementation of this ratio in clinical practice is limited.
M. N. Nan +15 more
wiley +1 more source
Study on the effects of down-regulating Annexin A3 expression on biological behaviors of lung adenocarcinoma and its molecular mechanism [PDF]
, 2015 肺癌是我国第一大癌症，其发病率和死亡率均居恶性肿瘤之首，严重危害人类健康。肺癌按组织学类型可分为鳞癌、腺癌、小细胞癌和大细胞癌。近年来，肺腺癌（lungadenocarcinoma，AdC）的发病率呈逐步上升趋势，且患者死亡率高、预后极差。癌细胞易转移是肺腺癌患者预后差的主要原因，因此，探寻肺腺癌转移的分子机制及其新的治疗靶标，对于提高肺腺癌患者预后意义重大。我们前期研究中，采用定量蛋白质组学技术鉴定出AnnexinA3（Anxa3）为一个新的肺腺癌转移相关分子 ...
刘青青
core
Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 3, Page 303-310, March 2025.ABSTRACT Objective Globally, one in four pregnant women is classified as overweight or obese, based on their prepregnancy body mass index (BMI). Obese pregnant women are at increased risk of adverse pregnancy outcomes and long‐term cardiovascular disease that occurs earlier in life.
M. Charakida +6 more
wiley +1 more source
Complete androgen insensitivity syndrome, a pedigree gene mutation analysis [PDF]
, 2016 研究背景 雄激素不敏感综合征（AndrogenInsensitivitySyndrome，AIS），是一种常见的男性假两性畸形。是伴X连锁隐性遗传病。患者染色体核型为46，XY，但其X染色体上的雄激素受体（Androgenreceptor，AR）基因存在缺陷，可致雄激素靶器官上的AR出现缺陷，体内的雄激素不能发挥相应的作用而出现相应的临床症状。此疾病可对患者的生殖能力造成不同程度的影响，还可能引发与性发育异常相关的性心理、性行为的异常，并可能给社会和患者家庭造成难以挽回的损失 ...
杨瑞娟
core
Prediction of pre‐eclampsia using maternal hemodynamic parameters at 12 + 0 to 15 + 6 weeks
Ultrasound in Obstetrics &Gynecology, Volume 65, Issue 2, Page 173-182, February 2025.ABSTRACT Objectives To compare the maternal hemodynamic profile at 12 + 0 to 15 + 6 weeks' gestation in women who subsequently developed pre‐eclampsia (PE) and those who did not, and to assess the screening performance of maternal hemodynamic parameters for PE in combination with the Fetal Medicine Foundation (FMF) triple test, including maternal ...
X. Wang +9 more
wiley +1 more source
Kinases Mst1 and Mst2 positively regulate phagocytic bactericidal activity [PDF]
, 2015 致病菌引发的恶性化脓和不可控感染一直是临床治疗的一项棘手难题。当细菌侵入后，天然防御细胞如巨噬细胞、嗜中性粒细胞等立即响应，识别并吞噬致病菌的同时调动胞内线粒体和NADPH氧化酶向吞噬泡内释放大量的活性氧（ROS），进而实现杀伤和清除细菌的功能。当这类细胞不能充分发挥杀伤和清除病原体的功能时，即使入侵的细菌数量较少或是致病力不强，也可能诱发机体破损部位或组织器官产生脓肿溃烂、炎症因子风暴和组织坏死，最终导致败血症或致死性脓毒性休克 ...
耿晶
core