Results 11 to 20 of about 229,027 (117)
弗雷德里克•班廷的发现形成了一种不需要移植就可能使胰岛新生的方法
Journal of Diabetes, 2022 On 31 October 1920, Sir Frederick Banting, while preparing for a medical student lecture on diabetes, a topic that he knew little about, learned how pancreatic stones resulted in the formation of new islets of Langerhans.
Claresa Levetan
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中西医结合护理, 2023 To review the clinical data and perioperative nursing of a child undergoing islet transplantation followed by kidney transplantation for diabetic mellitus complicated with renal failure.
LUO Xinchun (罗新春) +2 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 1986 对于糖尿病受体,胰岛移植以哪个部位最为合适和有效,各作者意见不一。免疫抑制剂在胰岛移植中的作用也尚有争论。本文通过腹腔内和肾包膜下的胰岛移植的实验研究,比较其疗效差别,并对免疫抑制剂的作用也作了初步观察。鉴于国内外实验性胰岛移植的胰岛分离较少采用组织培养的方法,而目前我国临床胰岛移植则多采用这一方法,因此,本实验所使用的胰岛分离方法为组织培养法,旨在使实验条件尽量接近我国的临床实际。
王吉甫
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Zhongshan Daxue xuebao. Yixue kexue ban, 2000 【目的】观察胰岛培养后胸腺内移植对移植物存活时间的影响。【方法】以C57BL/6 小鼠为受体, BALB/c 小鼠为 供体。胸腺内胰岛未培养组分为单纯移植和移植的同时加腹腔内1 次性注射兔抗小鼠胸腺细胞血清(ATS)两组。胸腺内胰 岛培养组分为24 ℃培养后单纯移植和移植时加用ATS 两组。【结果】未培养胰岛单纯胸腺内移植后平均存活期为(19.5 ± 10.1)d, 加用ATS 后, 可延长至100 d 以上, 其中6 只受体(6/ 8)胸腺内移植物长期存活, 并且诱导了受体对供体的特异性无 ...
王国栋, 陈规划
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Zhongshan Daxue xuebao. Yixue kexue ban, 2002 【目的】采用不同的分离或消化方法, 探讨如何提高大鼠胰岛细胞分离纯化后的收获量和质量。【方法】将25 只 供体SD 雄性大鼠依胰腺分离或消化的方法不同随机地分为5 组:①A 组:胆总管灌注胶原酶P ;②B 组:胆总管灌注Hanks 液;③C 组:胆总管不灌注液体;A、B 、C 3 组胰腺直接分次消化;④D 组:胆总管不灌注, 胰腺剪碎后分次消化;⑤对照组:胆总 管灌注胶原酶P, 胰腺直接单次消化。将分离的胰岛沉淀物用Ficoll-400 纯化并培养, 再把胰岛细胞移植于糖尿病裸鼠受体腹 腔内 ...
陈创奇 +6 more
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CD40LIg基因修饰骨髓间充质干细胞对异种胰岛移植排斥反应的抑制作用
Zhongshan Daxue xuebao. Yixue kexue ban, 2012 目的 探讨T细胞分化群40补体免疫球蛋白（CD40LIg）基因修饰骨髓间充质干细胞（MSCs）对异种胰岛移植排斥反应的抑制作用。方法 建立Wistar-SD大鼠异种胰岛移植模型，用携带CD40LIg基因的重组腺病毒感染的MSCs进行干预治疗，观察糖尿病大鼠胰岛移植后生存情况、血糖变化和移植物病理形态学改变,检测移植物CD40LIg和胰岛素的表达以及移植大鼠白细胞介素2（IL-2）和肿瘤坏死因子（TNF-α）的水平变化。结果 (1)糖尿病大鼠血糖平均在移植后2天恢复正常，对照组血糖平均在移植后7天升高 ...
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FTY720 预防小鼠同种异体胰岛移植的排斥反应 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2006 【目的】探讨 FTY720 在小鼠同种异体胰岛移植中的抗排斥作用及其机制。 【方法】36 只链脲霉素诱导的糖尿病小鼠 (C57BL/6) 随机分为 3 组 , 移植供体 (Balb/c 小鼠)胰岛后分别连续口服不同剂量的FTY720 或双蒸水( 对照组) , FTY720 剂量分别为 0.5 mg/(kg·d)(F0.5 组)和 1.0 mg/(kg·d)(F1.0 组)。术后连续测定血糖, 行组织学检查对比淋巴细胞浸润程度, 比较各组移植物中位存活时间( MST ...
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Influence of λ-Carrageenan Induced Gut Microbiota Disorder on Glucose Metabolism of Mice(λ-卡拉胶诱导的肠道菌群紊乱对小鼠糖代谢的影响) [PDF]
Shipin kexue jishu xuebao, 2023 Carrageenan is a common food additive, but its effect on changing the structure of gut microbiota was questioned. In this study, the C57BL/6 mice were given three dosages of λ-carrageenan, including low, medium and high dose (1.7,8.3,41.7mg/kg) for 12 ...
ZHAI Leilei(翟雷雷) +5 more
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Journal of Diabetes, Volume 14, Issue 4, Page 247-260, April 2022., 2022 Highlights Phosphoinositide 3‐kinase (PI3K)/Akt signaling is an emerging promising therapeutic target for diabetes. Modulation of the PI3K/Akt signaling pathway, via protein and peptide‐based biologics, parasite‐derived molecules, plant extracts, or through microRNA interactions, will regulate the processes that determine the function of β‐cells and ...
Inah Camaya +2 more
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中西医结合护理To summarized the clinical observation and nursing intervention on early recovery of islet function after allogeneic islet cell transplantation, and provide practical reference for clinical nursing management for such patients.
ZHANG Hongxia (张红霞) +6 more
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