Isatis tinctoria L. combined with costimulatory molecules blockade prolongs survival of cardiac allografts in alloantigen-primed mice [PDF]
, 2011 目的：这项研究的目标一是检测板蓝根化合物K对异型抗原预致敏小鼠脾脏中记忆性T细胞的体外同种反应性增殖强度的影响，目标二是检测K与效应性T细胞共刺激阻断剂联用，对二次同种异体心脏移植物存活时间的影响。目标三是探讨化合物K对二次同种异体心脏移植物可能的保护机制。 方法：皮肤移植小鼠再次心脏移植构建小鼠预致敏同种异体心脏移植模型，后联合应用板蓝根化合物K和共刺激通路阻断剂，观察移植物生存期的改变，并从记忆性T细胞和记忆性B细胞两个角度探讨其可能的作用机制。 结果：1、在体外试验中 ...
康向朋
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Study on the Effects and Mechanisms of Recombinant Human Prothymosin α in Metabolism of Glucose and Lipid [PDF]
, 2010 目前，人们正越来越多地食用高糖高脂食品。大量临床研究表明，长期食用高糖高脂食品将引起肥胖症，而肥胖将导致机体糖耐量作用下降，引发胰岛素抵抗，最终诱发2型糖尿病。更为严重的是，糖尿病将引发如酮症酸中毒、脑血管疾病、肾病等其它并发症。如何预防和治疗糖尿病及其并发症已经成为医学界关注的焦点。糖尿病的基本特征是胰岛β细胞的结构和功能受损，导致机体胰岛素分泌不足。依赖外供给胰岛素是目前主要的治疗方案，然而通过防止胰岛β细胞凋亡和促进胰岛β细胞分裂的角度进行研究，将是预防和治疗糖尿病的新途径。 经研究证实 ...
吴汉洲
core
[Research progress on the donor cell sources of pancreatic islet transplantation for treatment of diabetes mellitus]. [PDF]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2018 Zhu H +7 more
europepmc +1 more source
[Islet biomimetic microenvironment constructed by chitosan oligosaccharide protects islets from hypoxia-induced damage by reducing intracellular reactive oxygen species]. [PDF]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2022 Wang D +5 more
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[Developments in Research on the Relationship Between Porphyromonas gingivalis and Non-Oral Diseases]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue Ban, 2023 Zhang KK, Sun Y, Pan YH.
europepmc +1 more source
[Human umbilical cord mesenchymal stem cell grafting alleviates inflammatory response in type 1 diabetic mice by suppressing M1 macrophage polarization through Chi3l1]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoLiu X, Xu Y, Sheng H, Liu H.
europepmc +1 more source
[Monitoring and interventions of growth disorders and endocrine function in children with transfusion-dependent thalassemia]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiFan X, Huang YY.
europepmc +1 more source
[Role of Intestinal Mucosal Barrier in Type 2 Diabetes Mellitus and Research Progress in Chinese Medicine Interventions]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue BanYan C, Wang Q, Zhan L.
europepmc +1 more source
[Comprehensive considerations for the diagnosis, treatment, and management of osteogenesis imperfecta]. [PDF]
Zhongguo Dang Dai Er Ke Za ZhiLyu XH, Dong J.
europepmc +1 more source
[A case of multiple difficult illnesses in a patient with extremely severe burn complicated with type 2 diabetes]. [PDF]
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi, 2023 Wang Z, Zhang T, Liu SR, Rong XZ.
europepmc +1 more source