Results 1 to 10 of about 4,103 (144)

The link between obesity and insulin resistance among children: Effects of key metabolites. [PDF]

J Diabetes, 2023
Highlights Childhood obesity was significantly associated with the increased risk of insulin resistance (IR). There were 12 metabolites co‐associated with childhood obesity and IR, including seven amino acid and five fatty acid metabolites. The combination of body mass index standard deviation score and key metabolites could effectively predict the ...
Yan W, Wu S, Liu Q, Zheng Q, Gu W, Li X.
europepmc   +2 more sources

中枢胰岛素抵抗与脑血管病的关系 Relationship between Central Insulin Resistance and Cerebrovascular Disease

Zhongguo cuzhong zazhi, 2022
中枢胰岛素参与大脑的多种生理功能，对多种行为和代谢产生影响。中枢胰岛素抵抗的定义是脑细胞不能对胰岛素作出反应。胰岛素受体表达下调、胰岛素受体不能结合胰岛素以及胰岛素信号级联错误激活等原因都有可能导致中枢胰岛素抵抗。中枢胰岛素抵抗与脑血管病有着密切的关系。通过高胰岛素-正葡萄糖钳夹结合影像技术、经鼻给药、丝氨酸磷酸化与总磷酸化胰岛素受体底物比率和测定神经源性血浆外泌体中胰岛素受体底物1的水平及其磷酸化状态等方法可以对中枢胰岛素抵抗进行评估 ...
胥智超, 李润芝, 米东华
doaj   +2 more sources

[Association Between Surrogate Markers of Insulin Resistance and Incident Cardiovascular Disease in a Population With Stages 0-3 Cardiovascular-Kidney-Metabolic Syndrome: A Prospective Cohort Study]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
目的 探讨心肾代谢综合征（cardiovascular-kidney-metabolic syndrome, CKM）0-3期人群中8种胰岛素抵抗（insulin resistance, IR）替代标志物与新发动脉粥样硬化性心血管疾病（atherosclerotic cardiovascular disease, ASCVD）的关联，并选出预测性能最佳的替代指标。 方法 基于西南区域自然人群队列成都地区人群，对其中处于CKM 0-3期的20121名社区居民开展研究 ...
Zhao Y, Wang L, Li J, Guo B, Zhang J, Guo X, Luo Y, Wu G, Zhao X.   +8 more
europepmc   +2 more sources

运动诱导脂肪组织巨噬细胞表型变化对胰岛素抵抗的影响

体能科学, 2023
糖尿病（DM）是以糖脂代谢紊乱为主要特征的代谢障碍性疾病，2型糖尿病（T2DM）占90%以上，其主要表征为胰岛素抵抗（IR）。肥胖状态下，脂肪细胞会分泌趋化因子（MCP-I），吸引单核细胞进入脂肪组织和肝脏，极化为促炎巨噬细胞M1，M1巨噬细胞上调促炎介质的表达，如IL-6、TNF-α等，通过MAPK-JNK通路作用于脂肪细胞诱导IR。运动作为一种预防和治疗T2DM的非药物干预手段，可通过调节巨噬细胞表型，降低促炎介质TNF-α、IL-6表达水平，抑制脂肪组织MAPK-JNK通路活性改善胰岛素抵抗 ...
超 谢
semanticscholar   +3 more sources

Impact of visit-to-visit fasting plasma glucose variability on the development of diabetes: The mediation by insulin resistance. [PDF]

J Diabetes, 2022
Highlights A greater long‐term variability in fasting plasma glucose is significantly associated with an increased risk of incident diabetes. The association between fasting plasma glucose variability and incident diabetes could be partially mediated by an elevated homeostatic model assessment of insulin resistance.
Xu J, Li L, Huang S, Song H, Gao J, Ni H, Lin H, Wang S, Li M, Wang T, Zhao Z, Xu M, Lu J, Bi Y, Xu Y, Qian X.   +15 more
europepmc   +2 more sources

Beta‐cell function in type 2 diabetes (T2DM): Can it be preserved or enhanced? 2型糖尿病患者的β细胞功能:能被保留或增强吗?

Journal of Diabetes, Volume 15, Issue 10, Page 817-837, October 2023., 2023
Highlights Type 2 diabetes mellitus (T2DM) is characterized by progressive loss of beta‐cell function and mass. Numerous mechanisms of beta‐cell failure are involved. Preservation and/or enhancement of beta‐cell function is of great importance in delaying the progression of T2DM and the burden of its complications. Accurate evaluation of the effects of
Laure Sayyed Kassem, Aman Rajpal, Margarita Victoria Barreiro, Faramarz Ismail‐Beigi   +3 more
wiley   +1 more source

Increased glutamate in type 2 diabetes in the Korean population is associated with increased plasminogen levels 韩国2型糖尿病患者谷氨酸升高与纤溶酶原水平升高有关

Journal of Diabetes, Volume 15, Issue 9, Page 777-786, September 2023., 2023
Highlights Increased glutamate is associated with the development of diabetes. Glutamate increases plasminogen (PLG) levels through glutamate metabotropic receptor 5 activation with various insulin resistance‐related stresses. Glutamate inhibits the conversion of PLG to plasmin by increasing plasminogen activator inhibitor‐1.
Hyo Jung Lee, Jeong Won Yeom, Ji Ho Yun, Han Byul Jang, Min‐Gyu Yoo, Hyo‐Jin Kim, Soo Kyung Koo, Hye‐Ja Lee   +7 more
wiley   +1 more source

Weight loss and metabolic benefits of bariatric surgery in China: A multicenter study 减重手术的减重和代谢获益:一项中国多中心研究

Journal of Diabetes, Volume 15, Issue 9, Page 787-798, September 2023., 2023
Highlights Laparoscopic sleeve gastrectomy and laparoscopic Roux‐en‐Y gastric bypass are effective for reducing weight and improving metabolic parameters in Chinese patients with obesity. These interventions resulted in improved glycemic control, as evidenced by decreased glycated hemoglobin levels, reduced insulin resistance, and improved ...
Wenhuan Feng, Zhiming Zhu, Xiaoying Li, Zhiguang Zhou, Shen Qu, Xitai Sun, Dalong Zhu   +6 more
wiley   +1 more source

A Review of micro RNAs changes in T2DM in animals and humans miRNAs在2型糖尿病人类和动物中的变化

Journal of Diabetes, Volume 15, Issue 8, Page 649-664, August 2023., 2023
Highlights MicroRNAs (miRNAs) are overexpressed in inflammation, insulin resistance, and type 2 diabetes mellitus (T2DM). Many types of miRNAs are changed during the T2DM progression. miRNAs have a potential role as a biomarker in T2DM diagnosis. Abstract Type 2 diabetes mellitus (T2DM) and its associated complications have become a crucial public ...
Mohammad Reza Afsharmanesh, Zeinab Mohammadi, Azad Reza Mansourian, Seyyed Mehdi Jafari   +3 more
wiley   +1 more source

Effects of neprilysin and neprilysin inhibitors on glucose homeostasis: Controversial points and a promising arena 脑啡肽酶和脑啡肽酶抑制剂对葡萄糖稳态的影响:一个有争议的观点和有前景的领域

Journal of Diabetes, Volume 15, Issue 5, Page 397-408, May 2023., 2023
Highlights Neprilysin (NEP) inhibitors may lead to beneficial effects through inhibition of NEP, which involves impairment of glucose homeostasis through modulation of insulin resistance and the development of pancreatic β cell dysfunction as observed in type 2 diabetes mellitus.
Faisal Holil AlAnazi, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, Athanasios Alexiou, Marios Papadakis, Hanan A. Ogaly, Yousef Abud Alanazi, Hebatallah M. Saad, Gaber El‐Saber Batiha   +8 more
wiley   +1 more source