Results 21 to 30 of about 4,367 (160)

A Review of micro RNAs changes in T2DM in animals and humans miRNAs在2型糖尿病人类和动物中的变化

Journal of Diabetes, Volume 15, Issue 8, Page 649-664, August 2023., 2023
Highlights MicroRNAs (miRNAs) are overexpressed in inflammation, insulin resistance, and type 2 diabetes mellitus (T2DM). Many types of miRNAs are changed during the T2DM progression. miRNAs have a potential role as a biomarker in T2DM diagnosis. Abstract Type 2 diabetes mellitus (T2DM) and its associated complications have become a crucial public ...
Mohammad Reza Afsharmanesh, Zeinab Mohammadi, Azad Reza Mansourian, Seyyed Mehdi Jafari   +3 more
wiley   +1 more source

DiabetesWise: An innovative approach to promoting diabetes device awareness Diabetes wise:提高糖尿病器械认知度的创新方法

Journal of Diabetes, Volume 15, Issue 7, Page 597-606, July 2023., 2023
Highlights About a third of participants requested diabetes device prescriptions with 3 months of being invited to interact with DiabetesWise. Many factors predicted prior CGM use but diabetes distress was the only predictor of requesting a prescription after interacting with DiabetesWise.
Jessie J. Wong, Ananta Addala, Sarah J. Hanes, Sara Krugman, Diana Naranjo, Sierra Nelmes, Kyle Jacques Rose, Molly L. Tanenbaum, Korey K. Hood   +8 more
wiley   +1 more source

Relative contributions of fasting and postprandial glucose increments, glycemic variability, and non‐glycemic factors to HbA1c in individuals with type 1 diabetes 基于1型糖尿病患者的空腹和餐后血糖增量、血糖变异性和非血糖因素对HbA1C的相对贡献

Journal of Diabetes, Volume 15, Issue 6, Page 465-473, June 2023., 2023
Highlights Evidence for contribution of basal and postprandial glucose increments and glycemic variability to glycated hemoglobin (HbA1c) among adults with type 1 diabetes (T1D) is limited. In this study, after analyzing a total of 169 550 sensor‐derived data in 2409 meals recorded from 102 T1D adults, we found that basal hyperglycemia (BHG) was four ...
Yongwen Zhou, Mao Zheng, Hongrong Deng, Xueying Zheng, Sihui Luo, Daizhi Yang, Xiaodong Mai, Wen Xu, Jinhua Yan, Jianping Weng   +9 more
wiley   +1 more source

β‐Cell glucokinase expression was increased in type 2 diabetes subjects with better glycemic control 血糖控制较好的2型糖尿病患者β细胞葡萄糖激酶表达增加

Journal of Diabetes, Volume 15, Issue 5, Page 409-418, May 2023., 2023
Highlights A significant upregulation of glucokinase (GCK) expression was found in type 2 diabetes (T2D) subjects with adequate glucose control, but such increase was undetected in T2D with poor glycemic control. A strong positive correlation between GCK levels and spliced X‐box binding protein 1 (XBP1s)/activating transcription factor 4 (ATF4 ...
Jingwen Liu, Hui Fu, Fuyun Kang, Guang Ning, Qicheng Ni, Weiqing Wang, Qidi Wang   +6 more
wiley   +1 more source

Effectiveness, safety, initial optimal dose, and optimal maintenance dose range of basal insulin regimens for type 2 diabetes: A systematic review with meta‐analysis 基础胰岛素治疗2型糖尿病的有效性、安全性、初始最佳剂量和最佳维持剂量范围:一项meta分析的系统综述

Journal of Diabetes, Volume 15, Issue 5, Page 419-435, May 2023., 2023
Highlights This is a systematic review and meta‐analysis. MEDLINE, EMBASE, Web of Science, and the Cochrane Library were searched from January 2000 to February 2022. Among 11,163 citations retrieved, 35 publications met the pre‐planned criteria. The five basal insulins are effective for insulin‐naive adult patients with T2DM. Glargine U‐300, degludec U‐
Yingying Luo, Jun Xia, Zhan Zhao, Yaping Chang, Yong Mong Bee, Khue Thy Nguyen, Soo Lim, Daisuke Yabe, Margaret McGill, Alice Pik Shan Kong, Siew Pheng Chan, Marisa Deodat, Chaicharn Deerochanawong, Ketut Suastika, Chenchen Xu, Liming Chen, Wei Chen, Xiaoying Li, Weigang Zhao, Xiaomei Yao, Linong Ji   +20 more
wiley   +1 more source

Effects of neprilysin and neprilysin inhibitors on glucose homeostasis: Controversial points and a promising arena 脑啡肽酶和脑啡肽酶抑制剂对葡萄糖稳态的影响:一个有争议的观点和有前景的领域

Journal of Diabetes, Volume 15, Issue 5, Page 397-408, May 2023., 2023
Highlights Neprilysin (NEP) inhibitors may lead to beneficial effects through inhibition of NEP, which involves impairment of glucose homeostasis through modulation of insulin resistance and the development of pancreatic β cell dysfunction as observed in type 2 diabetes mellitus.
Faisal Holil AlAnazi, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, Athanasios Alexiou, Marios Papadakis, Hanan A. Ogaly, Yousef Abud Alanazi, Hebatallah M. Saad, Gaber El‐Saber Batiha   +8 more
wiley   +1 more source

Sleeve gastrectomy improved microvascular phenotypes from obesity cohort, detected with optical coherence tomography angiography 通过光学相干断层扫描血管成像检测发现袖状胃切除术改善肥胖队列的微血管表型

Journal of Diabetes, Volume 15, Issue 4, Page 313-324, April 2023., 2023
Highlights Different microvascular phenotypes were detected by noninvasive optical coherence tomography angiography (OCTA) in metabolically healthy obesity and metabolic syndrome patients. Baseline blood pressure and insulin status may be key determinants for vascular benefit from bariatric surgery.
Yaying Chen, Yanyang Liu, Lin Cong, Ailin Liu, Xiangyuan Song, Wenting Liu, Rong Hua, Qiwei Shen, Yikai Shao, Yiwen Xue, Qiyuan Yao, Yuyan Zhang   +11 more
wiley   +1 more source

Development and validation of risk prediction models for large for gestational age infants using logistic regression and two machine learning algorithms 使用Logistic回归和两种机器学习算法开发和验证大于胎龄儿风险预测模型

Journal of Diabetes, Volume 15, Issue 4, Page 338-348, April 2023., 2023
Highlights The logistic regression model consisted of seven commonly used clinical indicators (including lipid profile) and gestational diabetes mellitus subtypes, with an area under the curve (AUC) of 0.760 for the training set and 0.748 for the internal validation set.
Ning Wang, Haonan Guo, Yingyu Jing, Yifan Zhang, Bo Sun, Xingyan Pan, Huan Chen, Jing Xu, Mengjun Wang, Xi Chen, Lin Song, Wei Cui   +11 more
wiley   +1 more source

U‐shaped association between serum IGF2BP3 and T2DM: A cross‐sectional study in Chinese population 血清IGF2BP3与2型糖尿病的U型关联:一项中国人群横断面研究

Journal of Diabetes, Volume 15, Issue 4, Page 349-361, April 2023., 2023
Highlights This is the first cross‐sectional study of the association between serum IGF2BP3 levels and odds of T2DM in high‐risk Chinese population. Two upregulated (IGF2BP2 and IGF2BP3) and 5 downregulated (METTL3, ALKBH1, YTHDF2, YTHDF3, and HNRNPC) m6A‐related genes could contribute to the occurrence of T2DM.
Xiaoying Wu, Wei Wang, Shujin Fan, Lili You, Feng Li, Xiaoyun Zhang, Hongshi Wu, Juying Tang, Yiqin Qi, Wanting Feng, Li Yan, Meng Ren   +11 more
wiley   +1 more source

The toxicity of Rapamycin derivatives—Everolimus, Deforolimus, Zotarolimus on islet [PDF]

, 2016
目的：免疫抑制剂的开发与运用一直推动着器官移植领域的发展。自21世纪初，Edmonto方案被提出以后，胰岛移植领域发生的了质的飞跃，尤其是雷帕霉素与他克莫司的开发与利用，使得该方案得到广泛的认可与临床运用。然而随着研究的不断深入，研究者们发现免疫抑制剂在延长移植物存活时间的同时，也给胰岛本身带来了严重的毒性作用，包括抑制胰岛细胞增殖，促进胰岛细胞凋亡，抑制胰岛细胞分泌胰岛素等。应用免疫抑制剂产生的这些不良反应在抗器官移植排斥反应时发生。它们作为抗肿瘤药物应用于临床时也会诱发高血糖的现象。所以 ...
张娟
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