Results 31 to 40 of about 324,602 (155)
Highlights About a third of participants requested diabetes device prescriptions with 3 months of being invited to interact with DiabetesWise. Many factors predicted prior CGM use but diabetes distress was the only predictor of requesting a prescription after interacting with DiabetesWise.
Jessie J. Wong +8 more
wiley +1 more source
Highlights Evidence for contribution of basal and postprandial glucose increments and glycemic variability to glycated hemoglobin (HbA1c) among adults with type 1 diabetes (T1D) is limited. In this study, after analyzing a total of 169 550 sensor‐derived data in 2409 meals recorded from 102 T1D adults, we found that basal hyperglycemia (BHG) was four ...
Yongwen Zhou +9 more
wiley +1 more source
Highlights A significant upregulation of glucokinase (GCK) expression was found in type 2 diabetes (T2D) subjects with adequate glucose control, but such increase was undetected in T2D with poor glycemic control. A strong positive correlation between GCK levels and spliced X‐box binding protein 1 (XBP1s)/activating transcription factor 4 (ATF4 ...
Jingwen Liu +6 more
wiley +1 more source
Highlights This is a systematic review and meta‐analysis. MEDLINE, EMBASE, Web of Science, and the Cochrane Library were searched from January 2000 to February 2022. Among 11,163 citations retrieved, 35 publications met the pre‐planned criteria. The five basal insulins are effective for insulin‐naive adult patients with T2DM. Glargine U‐300, degludec U‐
Yingying Luo +20 more
wiley +1 more source
Highlights Neprilysin (NEP) inhibitors may lead to beneficial effects through inhibition of NEP, which involves impairment of glucose homeostasis through modulation of insulin resistance and the development of pancreatic β cell dysfunction as observed in type 2 diabetes mellitus.
Faisal Holil AlAnazi +8 more
wiley +1 more source
Highlights Different microvascular phenotypes were detected by noninvasive optical coherence tomography angiography (OCTA) in metabolically healthy obesity and metabolic syndrome patients. Baseline blood pressure and insulin status may be key determinants for vascular benefit from bariatric surgery.
Yaying Chen +11 more
wiley +1 more source
Highlights The logistic regression model consisted of seven commonly used clinical indicators (including lipid profile) and gestational diabetes mellitus subtypes, with an area under the curve (AUC) of 0.760 for the training set and 0.748 for the internal validation set.
Ning Wang +11 more
wiley +1 more source
Highlights This is the first cross‐sectional study of the association between serum IGF2BP3 levels and odds of T2DM in high‐risk Chinese population. Two upregulated (IGF2BP2 and IGF2BP3) and 5 downregulated (METTL3, ALKBH1, YTHDF2, YTHDF3, and HNRNPC) m6A‐related genes could contribute to the occurrence of T2DM.
Xiaoying Wu +11 more
wiley +1 more source
肠道菌群与疾病的关系为近年研究热点之一,肠-脑轴可能参与肥胖、糖尿病、多囊卵巢综合征(PCOS)等代谢相关疾病的发病机制。肠道菌群种类数量庞大,肠-脑轴的神经分泌调节机制尚不清楚,肠道菌群影响下丘脑-垂体-卵巢轴(HPO)的作用靶点难以准确定位。肠道内分泌激素近期受到关注,肠促胰素包括胰高血糖素样肽-1(GLP-1)和葡萄糖依赖性促胰岛素多肽(GIP)。这两种肠源性激素均可促进胰岛素的释放并降低血糖。目前国内外有关肠促胰素与HPO轴的研究较少,肠促胰素对PCOS的影响尚不明确。本文将综述该领域的研究进展,
李琳, 潘孟茹
core +1 more source
复方威灵仙颗粒对高尿酸血症患者血尿酸和胰岛素抵抗的影响 [PDF]
目的观察复方威灵仙颗粒对高尿酸血症(HUA)患者血尿酸(UA)临床疗效及胰岛素抵抗的影响。方法 HUA患者63例,随机分成复方威灵仙颗粒组31例和别嘌呤醇组32例,在基础治疗的基础上,分别给予复方威灵仙颗粒(1剂/d,2次/d)及别嘌呤醇片(100 mg/次,3次/d),8 w为1个疗程。观察治疗前后血UA及临床疗效、空腹血糖(FPG)、空腹胰岛素(FINS)及胰岛素抵抗指数。结果复方威灵仙颗粒组与别嘌呤醇组治疗后的血UA均较治疗前有明显下降(P〈0.01),治疗总有效率分别为86.7%与90 ...
冯桂贞, 吕崇山, 罗艾君
core +1 more source

