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多不饱和脂肪酸脂质过氧化在脑出血神经元铁死亡中的作用研究进展 [PDF]
浙江大学学报. 医学版铁死亡是一种与铁代谢紊乱和活性氧积累相关的调节性细胞死亡方式。脑出血后，由于血流量急剧减少以及红细胞释放铁离子，局部脑组织可通过一系列级联反应引发以多不饱和脂肪酸（PUFA）为主的脂质过氧化，这一过程参与了细胞铁死亡。同时，线粒体功能障碍和炎症反应可增加活性氧水平，加剧脂质过氧化，从而促进神经元铁死亡过程。因此，生物脂质过氧化及其相关生理过程参与脑出血患者神经元铁死亡。本文概述了脑出血后PUFA过氧化导致神经元铁死亡发生的作用机制，探究了脂质代谢紊乱和铁离子代谢在脑出血铁死亡中的相关调控机制 ...
郭 蔓 +4 more
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Effects of Oxidized Milk Protein Intaking During Gestation and Lactation on Redox Status in Offspring Mice(孕哺期摄入氧化乳蛋白对子代小鼠机体氧化还原状态的影响) [PDF]
Shipin kexue jishu xuebao, 2021 To study the effects of intaking oxidized milk protein with different fat content during pregnancy and lactation on the redox status of offspring mice, the whole milk and low-fat milk were oxidized by heat, then the contents of carbonyl and free thiol ...
MO Ling(莫玲) +4 more
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氧自由基及其清除剂SOD在阿霉素大鼠肾病模型中的作用 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 1992 用阿霉素(ADR)诱导雄性大鼠肾病模型,选用氧自由基清除剂超氧化物歧化酶(SOD),以及非氧自由基清除剂环孢素A(CSA)对动物模型进行干扰,结果显示其模型组动物在实验的第14天出现典型肾病综合征症候;SOD组动物的尿,血生化指标及病理损害得到明显的改善,且血清和肾皮质的丙二醛(MDA)含量也明显低于ADR模型组的指标;CSA组则无上述作用,提示ADR能致使动物肾病模型是与氧自由基、脂质过氧化损伤有关。
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Journal of Diabetes, Volume 15, Issue 12, Page 1081-1094, December 2023., 2023 Highlights Glucagon receptor (GCGR) monoclonal antibody (mAb) improves cardiac function and attenuates microvascular damage in db/db mice. GCGR mAb ameliorates the oxidative stress of cardiac microvascular endothelial cells in diabetic mice. GCGR mAb counteracts the diabetes‐induced upregulation of carnitine palmitoyltransferase 1B, optic atrophy type ...
Peng Wang +6 more
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Journal of Diabetes, Volume 13, Issue 2, Page 143-153, February 2021., 2021 Highlights A machine learning model can significantly predict imminent development of islet autoimmunity based on environmental, genetic, and metabolic features. The machine learning algorithm feature selection identified type 1 diabetes‐associated single nucleotide polymorphisms from The Environmental Determinants of the Diabetes in the Young (TEDDY ...
Bobbie‐Jo M. Webb‐Robertson +10 more
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Zhongguo youzhi, 2022 油脂氧化是导致乳化食品变质的主要原因。油脂中的不饱和脂肪酸发生氧化，不仅会降低乳化食品的营养价值，还会产生不良风味、有害成分，进而影响乳化食品货架期和食用安全。相对于纯油体系，以乳化形式存在的油脂在高油-水界面比下极易发生氧化，缩短乳化食品的货架期。为明确乳化食品中油脂氧化分析以及其货架期评价方法，在介绍乳化食品中油脂氧化的基本过程的基础上，综述了乳化食品中油脂氧化分析方法（过氧化值、共轭二烯值、硫代巴比妥酸值、茴香胺值、挥发性物质含量）以及货架期的评价方法 ...
李潇潇，陈小威，马传国 LI Xiaoxiao, CHEN Xiaowei, MA Chuanguo
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Research progress in ferroptosis regulation in the treatment of liver diseases [PDF]
, 2023 Ferroptosis is a form of cell death that results from accumulation of lipid reactive oxygen species, marked by iron-dependent oxidative damage of phospholipids. Accumulation of iron and lipid hydroperoxides are hallmarks of ferroptosis.
CHEN Chen +3 more
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Zhongguo youzhi, 2022 通过研究不同生长期对迷迭香脂溶性抗氧化物质（鼠尾草酸、鼠尾草酚和熊果酸）得率的影响筛选出最佳生长期，在此基础上测定不同干燥方式（阴干、烘干（45 ℃）和晾晒）下迷迭香脂溶性抗氧化物质得率，DPPH自由基、ABTS+自由基、羟自由基清除能力和铁还原力，以考察不同干燥方式对迷迭香脂溶性抗氧化物质抗氧化活性的影响。结果表明：迷迭香抗氧化物质积累的最佳生长期为10个月，3种不同干燥方式中烘干处理的迷迭香所提脂溶性抗氧化物质的得率最大，DPPH自由基、ABTS+自由基、羟自由基清除能力和铁还原力均最强 ...
王莹，邓慧，黄大川，曾祥辉，张钦，贺秋平 WANG Ying, DENG Hui, HUANG Dachuan, ZENG Xianghui, ZHANG Qin, HE Qiuping
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Comparison of Antioxidant Activities and Cytotoxicity in HepG2 Cells of Orientin and Isoorientin(荭草素和异荭草素抗氧化活性及对肝癌细胞增殖的影响) [PDF]
Shipin kexue jishu xuebao, 2014 Orientin and isoorientin are isomers and flavonoid compounds that can be extracted from several plant species. However, their biological activities remain poorly understood.
YUAN Li(袁 莉) +3 more
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Zhongguo youzhi, 2023 为改善现有9,10-二羟基硬脂酸合成存在的反应不连续、反应时间过长等问题,以油酸为原料，过氧化氢为氧化剂，在连续流反应器中合成9,10-二羟基硬脂酸，对催化剂进行了筛选，并对合成工艺条件进行单因素实验优化。结果表明，9，10-二羟基硬脂酸，合成的最佳工艺条件为以磷钨酸为催化剂、不使用溶剂、30%过氧化氢与油酸物质的量比3∶ 1、反应温度60 ℃、催化剂用量10%（以油酸质量计）、反应时间23.6 min，在此条件下油酸转化率为91.2%，9,10-二羟基硬脂酸选择性为82.6 ...
张铭远,邓林江,陈治家,钮腾飞 ZHANG Mingyuan，DENG Linjiang，CHEN Zhijia，NIU Tengfei
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