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Zhongguo cuzhong zazhi, 2022 缺血性卒中后氧化应激的失衡与卒中致残增加和不良预后相关。表观遗传调控可以通过DNA甲基化、组蛋白修饰等方式影响氧化应激，进而在卒中的进展中发挥作用。本文概述表观遗传调控在卒中后氧化应激反应过程中的作用，以期为缺血性卒中的治疗提供新的思路。 Abstract: Imbalance of oxidative stress after ischemic stroke is associated with increased disability risk and poor functional ...
王誉博, 李子孝, 王拥军
doaj +1 more source
Zhongguo tingli yuyan kangfu kexue zazhi, 2021 长期暴露于噪声环境会导致听觉系统发生进行性听力下降,产生暂时性听力性阈移或永久性听力阈移,引发噪声性听力损失(noise-induced hearing loss,NIHL)。随着NIHL损伤机制研究的深入,氧化应激损伤越来越受到关注,噪声暴露后产生的大量活性氧,不仅会直接对内耳产生一系列氧化损伤,其产生的次级代谢产物还会对内耳产生间接损伤,并激活诸多细胞凋亡信号传导通路,最终引起毛细胞大量凋亡,出现听力下降。随着氧化应激机制研究的深入,诸多针对性的抗氧化应激药物已被应用于噪声性听力损失的防治研究 ...
石磊, 蒋晴晴, 于宁, 杨仕明
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浙江大学学报. 医学版研究证实多种金属污染物暴露可诱导神经毒性，并与神经系统相关疾病的发生发展密切相关。铁死亡是细胞响应金属污染物暴露的细胞死亡方式，其与氧化应激、铁代谢、脂质过氧化等密切相关。近年研究发现，在铅、镉、锰、镍和锑等金属诱导的神经毒性中铁死亡发挥重要作用，如铅暴露通过氧化应激、铁代谢紊乱和炎症触发铁死亡；镉可通过铁离子代谢、氧化应激以及铁死亡相关信号通路引发铁死亡；锰可通过线粒体功能障碍、铁代谢紊乱和氧化应激促进铁死亡；镍可通过氧化应激影响线粒体功能以及破坏铁稳态并促进其中枢神经系统的脂质过氧化，激活铁死亡 ...
秦 子玉 +3 more
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Light‐Synergistic Enhanced Synaptic Devices Toward Superadditive In‐Sensor Computing
Rare Metals, Volume 45, Issue 10, October 2026.ABSTRACT Conventional neuromorphic devices face challenges in achieving efficient integration of light sensing and synaptic computation because of structural and material limitations. In this work, we developed an indium‐tin‐zinc oxide/transparent gelatin electrolyte synaptic transistor incorporating rare metal indium.
Wei Zhong +16 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2020 阿尔茨海默病（AD）是常见的神经变性病，氧化应激在AD 早期病理发生和发展中起到了重要的作用。在老化、早老素 1（PS1）突变及环境等共同作用下，脑内出现过度氧化应激，促进β-淀粉样蛋白（Aβ）的形成，Aβ可能为氧化应激作用下的适应性产物。氧自由基产生与清除的失衡还可导致海马神经元自噬功能异常，诱导细胞从自噬到死亡，其可能的机制是Notch1 通路失调。Notch1 通路的失调导致机体抗氧化应激能力丧失和淀粉样前体蛋白（APP）剪切增多、Aβ沉积，最终引起AD 病理的发生与发展 ...
刘军
doaj
Rare Metals, Volume 45, Issue 10, October 2026.ABSTRACT Calcium overload‐induced immunogenic cell death (ICD) holds great potential in antitumor immunotherapy, and it is a critical strategy for regulating multiple intracellular Ca2+ channels through inhibiting the endogenous Ca2+ efflux and promoting the exogenous Ca2+ influx.
Xingguo Xu +9 more
wiley +1 more source
Rare Metals, Volume 45, Issue 10, October 2026.ABSTRACT The immunosuppressive milieu of hepatocellular carcinoma (HCC) remains a major obstacle to durable antitumor responses. Mechanical‐energy‐driven piezocatalysis provides a noninvasive means of inducing oxidative damage and immunogenic tumor destruction; however, inefficient utilization of piezoinduced charges and insufficient localization of ...
Mingjian Zhang +7 more
wiley +1 more source
Rare Metals, Volume 45, Issue 9, September 2026.ABSTRACT With the rapid development of flexible electronics, there is an increasing demand for hydrogel‐based sensors with rapid fabrication, robust mechanical performance, and stable sensing behavior. Herein, a green and ultrafast self‐catalytic strategy is developed to fabricate a multifunctional hydrogel based on tannic acid‐coated cellulose ...
Jin Qian +6 more
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Rare Metals, Volume 45, Issue 9, September 2026.ABSTRACT Cisplatin‐related acute kidney injury (CP‐AKI) is a serious complication of cisplatin (CP) treated patients with cancer with high morbidity and mortality rates. It is directly related to the abnormal accumulation of CP in renal tubular epithelial cells, causing metabolic toxicity, DNA damage, and oxidative stress.
Minghe Jiang +12 more
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Rare Metals, Volume 45, Issue 9, September 2026.ABSTRACT Ti‐15Mo‐2.5Ag alloy exhibited a low modulus and strong antibacterial ability but poor bioactivity. To resolve this problem, sandblasting and anodization were used to create a hydrophilic and nano‐Ag2O‐containing TiO2 coating. Subsequently, the microstructure and physicochemical properties were investigated by scanning electron microscopy, X ...
Yanchun Xie +11 more
wiley +1 more source