Results 21 to 30 of about 1,066,892 (167)
The Oncologist, Volume 24, Issue 11, Page 1416-1419, November 2019., 2019 Abstract Immune checkpoint blockade (ICB) is an approved therapy for advanced metastatic mismatch repair (MMR)‐deficient cancer regardless of tissue of origin. Although therapy is effective initially, recurrence rates are significant, and long‐term outcomes remain poor for most patients.
Arthur Winer +7 more
wiley +1 more source
Aspect Ratio‐Controlled Chiral Nanostructures for Dual‐Mode Breast Cancer Theranostics
Rare Metals, Volume 45, Issue 5, May 2026.ABSTRACT Chiral CdSe/CdS quantum dots (QDs) have emerged as promising platforms for precise cancer diagnosis and therapy due to their unique optical properties and biological interactions. In this study, we systematically investigated the role of aspect ratio (AR) modulation in ultrathin‐shelled chiral CdSe/CdS dot‐in‐rods (DRs) on their performance in
Linxuan Wu +9 more
wiley +1 more source
Rare Metals, Volume 45, Issue 4, April 2026.ABSTRACT Diabetic wound infections are a common complication of diabetes, which severely impact patients' quality of life. Effective treatment of diabetic wound infections remains one major challenge in the clinic, partially due to the formation of bacterial biofilm and antibiotic resistance.
Liang Zhou +8 more
wiley +1 more source
Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT Periodontitis is a chronic infectious oral disease triggered by periodontopathogenic bacteria, resulting in the progressive inflammation and destruction of the tissues surrounding teeth. To achieve reprogramming of the infectious microenvironment for periodontitis therapy, a nanoformulation was proposed by loading polydopamine (PDA) with ...
Hao Liang +14 more
wiley +1 more source
Linchuang shenzangbing zazhi, 2015 随着对慢性肾脏病（chronic kidney disease,CKD）进展机制的不断探索发现,氧化应激、炎症反应与CKD的发生、发展密切相关,且随肾功能损害加重,其炎症及氧化应激状态增强,并且肾功能进展越快者炎症及氧化应激状态越明显[1]。本文以替米沙坦为对照药,探讨尿毒清颗粒对CKD患者肾功能的临床疗效及其对CKD患者氧化应激、微炎症状态的影响 ...
宋旸
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Rare Metals, Volume 45, Issue 3, March 2026.ABSTRACT MCrAlX coatings are widely used as bond coats in thermal barrier coating systems to protect turbine blades from high‐temperature oxidation. However, their oxidation resistance is often restricted by uncontrolled microstructures, surface roughness, and aggregation of reactive elements (REs). In this study, high‐repetition‐rate femtosecond laser
Wei Qian +7 more
wiley +1 more source
颅脑损伤并发应激性溃疡患者血清SOD、GAS和胃液pH值的变化及临床意义
Zhongguo shiyan zhenduanxue, 2014 颅脑损伤是威胁人类生命的主要创伤之一,颅脑损伤后的并发症是加重患者病情及影响预后的重要因素。颅脑损伤后,机体处于应激状态,容易导致应激性溃疡的发生。已有研究报道,颅脑损伤并发应激性溃疡患者血清超氧化物歧化酶（SOD）活力降低,提示机体处于氧化应激状态[1]。但氧化应激是否引起胃泌素（GAS）、胃酸增多尚未见报道。本研究对颅脑损伤并发应激性溃疡患者血清SOD、GAS和胃液pH值进行测定 ...
王亚林, 王万宏, 卢庆韬
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Zhejiang Daxue xuebao. Lixue ban, 2008 采用利用内源荧光、1-苯氨基萘-8-磺酸(ANS)荧光、酶活性的测定以及动力学分析等手段，研究肌酸激酶在氧化型的二硫基苏糖醇(DTT)溶液中的结构与活性的变化.结果表明：随着氧化型DTT浓度的增加，肌酸激酶的活性逐渐丧失，直至完全失活，并伴随着构象的变化.肌酸激酶起初微小的结构变化就会导致酶活性的迅速丧失，而且其的失活先于明显可测的整体构象变化，酶分子的活性部位处于柔性区域内.另外，随着氧化型DTT浓度的提高，肌酸激酶的内源荧光发射峰位明显地红移，外源ANS荧光强度显著增强，即酶分子的疏水面加大 ...
MAYong(马勇) +2 more
doaj +1 more source
Rare Metals, Volume 45, Issue 2, February 2026.ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang +7 more
wiley +1 more source
丹参素对缺氧/复氧诱导H9C2心肌细胞损伤和内质网应激的改善作用
Zhongguo shiyan zhenduanxue, 2020 目的观察丹参素(DLA)通过抑制内质网应激和凋亡对H9C2心肌细胞缺氧/复氧(H/R)后损伤的保护作用。方法将离体培养的H9C2心肌细胞随机分为3组:对照组、缺氧/复氧组(H/R组)、DLA+H/R组(DLA组)。H/R组先缺氧6h后复氧24h;DLA组于缺氧时给予DLA(10-6M)培养6h,再复氧24h。对照组心肌细胞正常培养至实验结束。ELISA测定细胞中乳酸脱氢酶(LDH)、肌酸激酶MB同工酶(CK-MB)和丙二醛(MDA)的含量;Western ...
丁玉红, 郭秀颖
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